Role of nerve signal transduction and neuroimmune crosstalk in mediating the analgesic effects of acupuncture for neuropathic pain
Neurogenic pain rises because of nervous system damage or dysfunction and is the most difficult to treat among other pathological pains. Acupuncture has been reported as a great treatment option for neurogenic pain owing to its unlimited advantages. However, previous studies on the analgesic effects...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1093849/full |
| _version_ | 1828056504941412352 |
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| author | Yong Chen Yong Chen Dan Li Dan Li Ningcen Li PeiYong Loh Yi Guo Yi Guo Yi Guo Xiyou Hu Xiyou Hu Jingyu Zhang Jingyu Zhang Baomin Dou Baomin Dou Lifen Wang Lifen Wang Chaobo Yang Chaobo Yang Tao Guo Tao Guo Shuangli Chen Shuangli Chen Zhen Liu Zhen Liu Bo Chen Bo Chen Bo Chen Zelin Chen Zelin Chen Zelin Chen |
| author_facet | Yong Chen Yong Chen Dan Li Dan Li Ningcen Li PeiYong Loh Yi Guo Yi Guo Yi Guo Xiyou Hu Xiyou Hu Jingyu Zhang Jingyu Zhang Baomin Dou Baomin Dou Lifen Wang Lifen Wang Chaobo Yang Chaobo Yang Tao Guo Tao Guo Shuangli Chen Shuangli Chen Zhen Liu Zhen Liu Bo Chen Bo Chen Bo Chen Zelin Chen Zelin Chen Zelin Chen |
| author_sort | Yong Chen |
| collection | DOAJ |
| description | Neurogenic pain rises because of nervous system damage or dysfunction and is the most difficult to treat among other pathological pains. Acupuncture has been reported as a great treatment option for neurogenic pain owing to its unlimited advantages. However, previous studies on the analgesic effects of acupuncture for NP were scattered and did not form a whole. In this study, we first comprehensively review the relevant basic articles on acupuncture for NP published in the last 5 years and summarize the analgesic mechanisms of acupuncture in terms of nerve signaling, neuro-immune crosstalk, and metabolic and oxidative stress regulation. Acupuncture inhibits the upstream excitatory system and suppresses neuronal transmission efficiency by downregulating glutamate, NMDA receptors, P2XR, SP, CGRP, and other neurotransmitters and receptors in the spinal cord, as well as plasma channels such as TRPV1, HCN. It can also activate the downstream pain inhibitory pathway by upregulating opioid peptide (β-endorphin), MOR receptors, GABA and GABA receptors, bi-directional regulating 5-hydroxytryptamine (5-HT) and its receptors (upregulate 5-HT 1A and downregulate 5-HT7R) and stimulating hypothalamic appetite-modifying neurons. Moreover, neuroinflammation in pain can be inhibited by acupuncture through inhibiting JAK2/STAT3, PI3K/mTOR pathways, down regulating chemokine receptor CX3CR1 on microglia and up regulating adenosine receptor A1Rs on astrocytes, inhibiting the activation of glia and reducing TNF-α and other inflammatory substances. Acupuncture also inhibits neuronal glucose metabolism by downregulating mPFC's GLUT-3 and promotes metabolic alterations of the brain, thus exerting an analgesic effect. In conclusion, the regulation of nerve signal transduction and neuroimmune crosstalk at the peripheral and central levels mediates the analgesic effects of acupuncture for neuropathic pain in an integrated manner. These findings provide a reliable basis for better clinical application of acupuncture in the management of neuropathic pain. |
| first_indexed | 2024-04-10T20:56:20Z |
| format | Article |
| id | doaj.art-161df6b82b2044709062da1e1bbd9a8e |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T20:56:20Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-161df6b82b2044709062da1e1bbd9a8e2023-01-23T04:45:36ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-01-011410.3389/fneur.2023.10938491093849Role of nerve signal transduction and neuroimmune crosstalk in mediating the analgesic effects of acupuncture for neuropathic painYong Chen0Yong Chen1Dan Li2Dan Li3Ningcen Li4PeiYong Loh5Yi Guo6Yi Guo7Yi Guo8Xiyou Hu9Xiyou Hu10Jingyu Zhang11Jingyu Zhang12Baomin Dou13Baomin Dou14Lifen Wang15Lifen Wang16Chaobo Yang17Chaobo Yang18Tao Guo19Tao Guo20Shuangli Chen21Shuangli Chen22Zhen Liu23Zhen Liu24Bo Chen25Bo Chen26Bo Chen27Zelin Chen28Zelin Chen29Zelin Chen30Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaResearch Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaLaboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaSchool of International Education, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaResearch Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaResearch Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaResearch Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaResearch Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaResearch Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaResearch Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaResearch Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaResearch Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaResearch Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaResearch Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaResearch Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNeurogenic pain rises because of nervous system damage or dysfunction and is the most difficult to treat among other pathological pains. Acupuncture has been reported as a great treatment option for neurogenic pain owing to its unlimited advantages. However, previous studies on the analgesic effects of acupuncture for NP were scattered and did not form a whole. In this study, we first comprehensively review the relevant basic articles on acupuncture for NP published in the last 5 years and summarize the analgesic mechanisms of acupuncture in terms of nerve signaling, neuro-immune crosstalk, and metabolic and oxidative stress regulation. Acupuncture inhibits the upstream excitatory system and suppresses neuronal transmission efficiency by downregulating glutamate, NMDA receptors, P2XR, SP, CGRP, and other neurotransmitters and receptors in the spinal cord, as well as plasma channels such as TRPV1, HCN. It can also activate the downstream pain inhibitory pathway by upregulating opioid peptide (β-endorphin), MOR receptors, GABA and GABA receptors, bi-directional regulating 5-hydroxytryptamine (5-HT) and its receptors (upregulate 5-HT 1A and downregulate 5-HT7R) and stimulating hypothalamic appetite-modifying neurons. Moreover, neuroinflammation in pain can be inhibited by acupuncture through inhibiting JAK2/STAT3, PI3K/mTOR pathways, down regulating chemokine receptor CX3CR1 on microglia and up regulating adenosine receptor A1Rs on astrocytes, inhibiting the activation of glia and reducing TNF-α and other inflammatory substances. Acupuncture also inhibits neuronal glucose metabolism by downregulating mPFC's GLUT-3 and promotes metabolic alterations of the brain, thus exerting an analgesic effect. In conclusion, the regulation of nerve signal transduction and neuroimmune crosstalk at the peripheral and central levels mediates the analgesic effects of acupuncture for neuropathic pain in an integrated manner. These findings provide a reliable basis for better clinical application of acupuncture in the management of neuropathic pain.https://www.frontiersin.org/articles/10.3389/fneur.2023.1093849/fullacupunctureanalgesic effectsneuropathic painnerve signal transductionneuroimmune crosstalkmetabolic and oxidative stress regulation |
| spellingShingle | Yong Chen Yong Chen Dan Li Dan Li Ningcen Li PeiYong Loh Yi Guo Yi Guo Yi Guo Xiyou Hu Xiyou Hu Jingyu Zhang Jingyu Zhang Baomin Dou Baomin Dou Lifen Wang Lifen Wang Chaobo Yang Chaobo Yang Tao Guo Tao Guo Shuangli Chen Shuangli Chen Zhen Liu Zhen Liu Bo Chen Bo Chen Bo Chen Zelin Chen Zelin Chen Zelin Chen Role of nerve signal transduction and neuroimmune crosstalk in mediating the analgesic effects of acupuncture for neuropathic pain Frontiers in Neurology acupuncture analgesic effects neuropathic pain nerve signal transduction neuroimmune crosstalk metabolic and oxidative stress regulation |
| title | Role of nerve signal transduction and neuroimmune crosstalk in mediating the analgesic effects of acupuncture for neuropathic pain |
| title_full | Role of nerve signal transduction and neuroimmune crosstalk in mediating the analgesic effects of acupuncture for neuropathic pain |
| title_fullStr | Role of nerve signal transduction and neuroimmune crosstalk in mediating the analgesic effects of acupuncture for neuropathic pain |
| title_full_unstemmed | Role of nerve signal transduction and neuroimmune crosstalk in mediating the analgesic effects of acupuncture for neuropathic pain |
| title_short | Role of nerve signal transduction and neuroimmune crosstalk in mediating the analgesic effects of acupuncture for neuropathic pain |
| title_sort | role of nerve signal transduction and neuroimmune crosstalk in mediating the analgesic effects of acupuncture for neuropathic pain |
| topic | acupuncture analgesic effects neuropathic pain nerve signal transduction neuroimmune crosstalk metabolic and oxidative stress regulation |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1093849/full |
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