Analysis of characteristics of four patients with adrenal unicentric Castleman disease
BackgroundCastleman Disease (CD) is a group of diseases with characteristic lymph node histopathology, characterized by marked enlargement of deep or superficial lymph nodes. Adrenal CD is rarely reported, and an accurate preoperative diagnosis of adrenal CD is difficult.MethodWe report four cases o...
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| Format: | Article |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1181929/full |
| _version_ | 1797825437539237888 |
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| author | Hao Yu Hao Yu Yuepeng Wang Yuepeng Wang Yuepeng Wang Yijun Li Jin Du Qinghua Guo Weijun Gu Zhaohui Lyu Jingtao Dou Yiming Mu Li Zang |
| author_facet | Hao Yu Hao Yu Yuepeng Wang Yuepeng Wang Yuepeng Wang Yijun Li Jin Du Qinghua Guo Weijun Gu Zhaohui Lyu Jingtao Dou Yiming Mu Li Zang |
| author_sort | Hao Yu |
| collection | DOAJ |
| description | BackgroundCastleman Disease (CD) is a group of diseases with characteristic lymph node histopathology, characterized by marked enlargement of deep or superficial lymph nodes. Adrenal CD is rarely reported, and an accurate preoperative diagnosis of adrenal CD is difficult.MethodWe report four cases of CD in the adrenal gland confirmed by pathology and review the characteristics of this rare disease, highlighting the necessity of diagnostic evaluation and follow-up of the patients.ResultsAll of the patients sought medical advice because of adrenal incidentalomas. No significant abnormalities were presented in the biochemistry or endocrine systems. The imaging suggested a moderate-to-large mass with uneven moderate contrast enhancement of the adrenal region, similar to a pheochromocytoma. All cases were misdiagnosed as pheochromocytomas before operation and finally confirmed by histopathology. Three cases were pathologically diagnosed as hyaline vascular CD, and one case was diagnosed as plasma cell CD. All the patients are alive without recurrence after a median follow-up of 8 years.ConclusionThe adrenal CD should be considered after excluding pheochromocytoma and malignancy in the adrenal region. The long-term prognosis of patients with complete resection of the mass is excellent. |
| first_indexed | 2024-03-13T10:54:00Z |
| format | Article |
| id | doaj.art-161ffcb59d1d4f4796ebe55d119df225 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-13T10:54:00Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-161ffcb59d1d4f4796ebe55d119df2252023-05-17T05:39:37ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-05-011410.3389/fendo.2023.11819291181929Analysis of characteristics of four patients with adrenal unicentric Castleman diseaseHao Yu0Hao Yu1Yuepeng Wang2Yuepeng Wang3Yuepeng Wang4Yijun Li5Jin Du6Qinghua Guo7Weijun Gu8Zhaohui Lyu9Jingtao Dou10Yiming Mu11Li Zang12Department of Endocrinology, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Endocrinology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Endocrinology, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Endocrinology, General Hospital of Northern Theater Command, Shenyang, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaDepartment of Endocrinology, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Endocrinology, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Endocrinology, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Endocrinology, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Endocrinology, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Endocrinology, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Endocrinology, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Endocrinology, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaBackgroundCastleman Disease (CD) is a group of diseases with characteristic lymph node histopathology, characterized by marked enlargement of deep or superficial lymph nodes. Adrenal CD is rarely reported, and an accurate preoperative diagnosis of adrenal CD is difficult.MethodWe report four cases of CD in the adrenal gland confirmed by pathology and review the characteristics of this rare disease, highlighting the necessity of diagnostic evaluation and follow-up of the patients.ResultsAll of the patients sought medical advice because of adrenal incidentalomas. No significant abnormalities were presented in the biochemistry or endocrine systems. The imaging suggested a moderate-to-large mass with uneven moderate contrast enhancement of the adrenal region, similar to a pheochromocytoma. All cases were misdiagnosed as pheochromocytomas before operation and finally confirmed by histopathology. Three cases were pathologically diagnosed as hyaline vascular CD, and one case was diagnosed as plasma cell CD. All the patients are alive without recurrence after a median follow-up of 8 years.ConclusionThe adrenal CD should be considered after excluding pheochromocytoma and malignancy in the adrenal region. The long-term prognosis of patients with complete resection of the mass is excellent.https://www.frontiersin.org/articles/10.3389/fendo.2023.1181929/fullcastleman diseaseadrenal glandlymphomaadrenal incidentalomapheochromocytoma |
| spellingShingle | Hao Yu Hao Yu Yuepeng Wang Yuepeng Wang Yuepeng Wang Yijun Li Jin Du Qinghua Guo Weijun Gu Zhaohui Lyu Jingtao Dou Yiming Mu Li Zang Analysis of characteristics of four patients with adrenal unicentric Castleman disease Frontiers in Endocrinology castleman disease adrenal gland lymphoma adrenal incidentaloma pheochromocytoma |
| title | Analysis of characteristics of four patients with adrenal unicentric Castleman disease |
| title_full | Analysis of characteristics of four patients with adrenal unicentric Castleman disease |
| title_fullStr | Analysis of characteristics of four patients with adrenal unicentric Castleman disease |
| title_full_unstemmed | Analysis of characteristics of four patients with adrenal unicentric Castleman disease |
| title_short | Analysis of characteristics of four patients with adrenal unicentric Castleman disease |
| title_sort | analysis of characteristics of four patients with adrenal unicentric castleman disease |
| topic | castleman disease adrenal gland lymphoma adrenal incidentaloma pheochromocytoma |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1181929/full |
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