The Effect of Some 4,2 and 5,2 Bisthiazole Derivatives on Nitro-Oxidative Stress and Phagocytosis in Acute Experimental Inflammation
Nineteen bisthiazoles were tested in order to assess their anti-inflammatory and antioxidant properties. First, we evaluated the in vitro direct antioxidant capacity of the bisthiazoles using the DPPH radical scavenging method. Then, the anti-inflammatory effect was tested in acute rat experimental...
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MDPI AG
2014-07-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/7/9240 |
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| author | Cătălin Araniciu Alina Elena Pârvu Mariana Doina Palage Smaranda Dafina Oniga Daniela Benedec Ilioara Oniga Ovidiu Oniga |
| author_facet | Cătălin Araniciu Alina Elena Pârvu Mariana Doina Palage Smaranda Dafina Oniga Daniela Benedec Ilioara Oniga Ovidiu Oniga |
| author_sort | Cătălin Araniciu |
| collection | DOAJ |
| description | Nineteen bisthiazoles were tested in order to assess their anti-inflammatory and antioxidant properties. First, we evaluated the in vitro direct antioxidant capacity of the bisthiazoles using the DPPH radical scavenging method. Then, the anti-inflammatory effect was tested in acute rat experimental inflammation by measuring the acute phase bone marrow response, the phagocytic capacity and the serum nitro-oxidative stress status. Although none of the substances showed significant direct antioxidant potential in the DPPH assay, most of them improved serum oxidative status, when administered to rats with inflammation. Four of the bisthiazoles proved to have good anti-inflammatory properties, similar or superior to that of equal doses meloxicam. |
| first_indexed | 2024-12-18T19:36:22Z |
| format | Article |
| id | doaj.art-1622b613b78249e0bb2fc3dbeb1a1691 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-18T19:36:22Z |
| publishDate | 2014-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1622b613b78249e0bb2fc3dbeb1a16912022-12-21T20:55:35ZengMDPI AGMolecules1420-30492014-07-011979240925610.3390/molecules19079240molecules19079240The Effect of Some 4,2 and 5,2 Bisthiazole Derivatives on Nitro-Oxidative Stress and Phagocytosis in Acute Experimental InflammationCătălin Araniciu0Alina Elena Pârvu1Mariana Doina Palage2Smaranda Dafina Oniga3Daniela Benedec4Ilioara Oniga5Ovidiu Oniga6Department of Therapeutic Chemistry, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 12 Ion Creanga Street, 400010 Cluj-Napoca, RomaniaDepartment of Physiopathology, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, 2-4 Victor Babes Street, 400010 Cluj-Napoca, RomaniaDepartment of Therapeutic Chemistry, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 12 Ion Creanga Street, 400010 Cluj-Napoca, RomaniaDepartment of Therapeutic Chemistry, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 12 Ion Creanga Street, 400010 Cluj-Napoca, RomaniaDepartment of Pharmacognosy, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 12 I. Creanga Street, 400010 Cluj-Napoca, RomaniaDepartment of Pharmacognosy, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 12 I. Creanga Street, 400010 Cluj-Napoca, RomaniaDepartment of Therapeutic Chemistry, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 12 Ion Creanga Street, 400010 Cluj-Napoca, RomaniaNineteen bisthiazoles were tested in order to assess their anti-inflammatory and antioxidant properties. First, we evaluated the in vitro direct antioxidant capacity of the bisthiazoles using the DPPH radical scavenging method. Then, the anti-inflammatory effect was tested in acute rat experimental inflammation by measuring the acute phase bone marrow response, the phagocytic capacity and the serum nitro-oxidative stress status. Although none of the substances showed significant direct antioxidant potential in the DPPH assay, most of them improved serum oxidative status, when administered to rats with inflammation. Four of the bisthiazoles proved to have good anti-inflammatory properties, similar or superior to that of equal doses meloxicam.http://www.mdpi.com/1420-3049/19/7/9240anti-inflammatorynitro-oxidative stressiNOSbisthiazolesantioxidant |
| spellingShingle | Cătălin Araniciu Alina Elena Pârvu Mariana Doina Palage Smaranda Dafina Oniga Daniela Benedec Ilioara Oniga Ovidiu Oniga The Effect of Some 4,2 and 5,2 Bisthiazole Derivatives on Nitro-Oxidative Stress and Phagocytosis in Acute Experimental Inflammation Molecules anti-inflammatory nitro-oxidative stress iNOS bisthiazoles antioxidant |
| title | The Effect of Some 4,2 and 5,2 Bisthiazole Derivatives on Nitro-Oxidative Stress and Phagocytosis in Acute Experimental Inflammation |
| title_full | The Effect of Some 4,2 and 5,2 Bisthiazole Derivatives on Nitro-Oxidative Stress and Phagocytosis in Acute Experimental Inflammation |
| title_fullStr | The Effect of Some 4,2 and 5,2 Bisthiazole Derivatives on Nitro-Oxidative Stress and Phagocytosis in Acute Experimental Inflammation |
| title_full_unstemmed | The Effect of Some 4,2 and 5,2 Bisthiazole Derivatives on Nitro-Oxidative Stress and Phagocytosis in Acute Experimental Inflammation |
| title_short | The Effect of Some 4,2 and 5,2 Bisthiazole Derivatives on Nitro-Oxidative Stress and Phagocytosis in Acute Experimental Inflammation |
| title_sort | effect of some 4 2 and 5 2 bisthiazole derivatives on nitro oxidative stress and phagocytosis in acute experimental inflammation |
| topic | anti-inflammatory nitro-oxidative stress iNOS bisthiazoles antioxidant |
| url | http://www.mdpi.com/1420-3049/19/7/9240 |
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