Influence of Hemoglobin Level on Muscle and Physical Functions, Activities of Daily Living, and Quality of Life in Patients With Hematological Malignancies
Purpose. Patients with hematological malignancies often present with reduced muscle and physical functions, which are caused by the disease or related treatment. Moreover, patients with hematological malignancies rapidly develop low hemoglobin levels, and this may affect muscle and physical function...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-04-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/1534735419842196 |
| _version_ | 1819330690923102208 |
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| author | Takuya Fukushima PhD Jiro Nakano PhD Shun Ishii BSc Ayumi Natsuzako MSc Haruna Kawachi MSc Junya Sakamoto PhD Yasushi Miyazaki PhD Minoru Okita PhD |
| author_facet | Takuya Fukushima PhD Jiro Nakano PhD Shun Ishii BSc Ayumi Natsuzako MSc Haruna Kawachi MSc Junya Sakamoto PhD Yasushi Miyazaki PhD Minoru Okita PhD |
| author_sort | Takuya Fukushima PhD |
| collection | DOAJ |
| description | Purpose. Patients with hematological malignancies often present with reduced muscle and physical functions, which are caused by the disease or related treatment. Moreover, patients with hematological malignancies rapidly develop low hemoglobin levels, and this may affect muscle and physical functions. This study aimed to identify the influence of hemoglobin levels on muscle and physical functions in patients with hematological malignancies. Methods. Using a cross-sectional study design, this study included 60 patients with hematological malignancies (mean age = 68.0 ± 10.2 years, women 56.7%) who were hospitalized for chemotherapy- and radiotherapy-related side effects and underwent examination for skeletal muscle mass (SMM), muscle strength, physical function, activities of daily living (ADLs), psychological status, and quality-of-life (QOL), including physical symptoms. Participants were divided into 3 groups according to tertiles of hemoglobin levels: low (n = 19), middle (n = 20), and high (n = 21). Evaluation items were compared among the 3 groups. Results. There was no significant difference among the 3 groups in terms of SMM. The low hemoglobin group showed significantly higher values of fatigue and dyspnea and lower values of muscle strength, ADLs, and QOL than the high hemoglobin group. Conclusions. Hemoglobin levels did not affect SMM; however, muscle weakness, decrease in physical function, physical symptoms such as fatigue and dyspnea, and decline in ADLs and QOL were observed in patients with low hemoglobin levels. |
| first_indexed | 2024-12-24T14:02:32Z |
| format | Article |
| id | doaj.art-1623ab966553457a8d361c0bafda1b00 |
| institution | Directory Open Access Journal |
| issn | 1552-695X |
| language | English |
| last_indexed | 2024-12-24T14:02:32Z |
| publishDate | 2019-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-1623ab966553457a8d361c0bafda1b002022-12-21T16:52:26ZengSAGE PublishingIntegrative Cancer Therapies1552-695X2019-04-011810.1177/1534735419842196Influence of Hemoglobin Level on Muscle and Physical Functions, Activities of Daily Living, and Quality of Life in Patients With Hematological MalignanciesTakuya Fukushima PhD0Jiro Nakano PhD1Shun Ishii BSc2Ayumi Natsuzako MSc3Haruna Kawachi MSc4Junya Sakamoto PhD5Yasushi Miyazaki PhD6Minoru Okita PhD7Nagasaki University Hospital, Nagasaki, JapanNagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanNagasaki University Hospital, Nagasaki, JapanNagasaki University Hospital, Nagasaki, JapanSaga-ken Medical Center Koseikan, Saga, JapanNagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, NagasakiUniversity Graduate School of Biomedical Sciences, Nagasaki, JapanNagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanPurpose. Patients with hematological malignancies often present with reduced muscle and physical functions, which are caused by the disease or related treatment. Moreover, patients with hematological malignancies rapidly develop low hemoglobin levels, and this may affect muscle and physical functions. This study aimed to identify the influence of hemoglobin levels on muscle and physical functions in patients with hematological malignancies. Methods. Using a cross-sectional study design, this study included 60 patients with hematological malignancies (mean age = 68.0 ± 10.2 years, women 56.7%) who were hospitalized for chemotherapy- and radiotherapy-related side effects and underwent examination for skeletal muscle mass (SMM), muscle strength, physical function, activities of daily living (ADLs), psychological status, and quality-of-life (QOL), including physical symptoms. Participants were divided into 3 groups according to tertiles of hemoglobin levels: low (n = 19), middle (n = 20), and high (n = 21). Evaluation items were compared among the 3 groups. Results. There was no significant difference among the 3 groups in terms of SMM. The low hemoglobin group showed significantly higher values of fatigue and dyspnea and lower values of muscle strength, ADLs, and QOL than the high hemoglobin group. Conclusions. Hemoglobin levels did not affect SMM; however, muscle weakness, decrease in physical function, physical symptoms such as fatigue and dyspnea, and decline in ADLs and QOL were observed in patients with low hemoglobin levels.https://doi.org/10.1177/1534735419842196 |
| spellingShingle | Takuya Fukushima PhD Jiro Nakano PhD Shun Ishii BSc Ayumi Natsuzako MSc Haruna Kawachi MSc Junya Sakamoto PhD Yasushi Miyazaki PhD Minoru Okita PhD Influence of Hemoglobin Level on Muscle and Physical Functions, Activities of Daily Living, and Quality of Life in Patients With Hematological Malignancies Integrative Cancer Therapies |
| title | Influence of Hemoglobin Level on Muscle and Physical Functions, Activities of Daily Living, and Quality of Life in Patients With Hematological Malignancies |
| title_full | Influence of Hemoglobin Level on Muscle and Physical Functions, Activities of Daily Living, and Quality of Life in Patients With Hematological Malignancies |
| title_fullStr | Influence of Hemoglobin Level on Muscle and Physical Functions, Activities of Daily Living, and Quality of Life in Patients With Hematological Malignancies |
| title_full_unstemmed | Influence of Hemoglobin Level on Muscle and Physical Functions, Activities of Daily Living, and Quality of Life in Patients With Hematological Malignancies |
| title_short | Influence of Hemoglobin Level on Muscle and Physical Functions, Activities of Daily Living, and Quality of Life in Patients With Hematological Malignancies |
| title_sort | influence of hemoglobin level on muscle and physical functions activities of daily living and quality of life in patients with hematological malignancies |
| url | https://doi.org/10.1177/1534735419842196 |
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