Evaluating Adherence of Health-Care Team to Standard Guideline of Colistin Use at Intensive Care Units of a Referral Hospital in Shiraz, Southwest of Iran
Purpose: To evaluate colistin use according to global standard drug consumption in intensive care units of a referral hospital in Shiraz, Iran Methods: A prospective, interventional study was performed during an 11 month period on 100 patients admitted to ICUs of a teaching hospital being treated wi...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tabriz University of Medical Sciences
2017-09-01
|
| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/APB/Manuscript/APB-7-391.pdf |
| _version_ | 1811251582557224960 |
|---|---|
| author | Afsaneh Vazin Iman Karimzadeh Atiyeh Zand Nazafarin Hatami-Mazinani Dena Firouzabadi |
| author_facet | Afsaneh Vazin Iman Karimzadeh Atiyeh Zand Nazafarin Hatami-Mazinani Dena Firouzabadi |
| author_sort | Afsaneh Vazin |
| collection | DOAJ |
| description | Purpose: To evaluate colistin use according to global standard drug consumption in intensive care units of a referral hospital in Shiraz, Iran Methods: A prospective, interventional study was performed during an 11 month period on 100 patients admitted to ICUs of a teaching hospital being treated with colistin for at least 3 subsequent doses. Required demographic, clinical, and paraclinical data were gathered by a pharmacist. Fifteen indexes were considered to evaluate colistin use. A clinical pharmacist reviewed indication and dose of colistin at the time of prescribing this agent. Results: In our study population, pneumonia (69%) was the main indication of colistin. In 87% of patients, colistin administration was based on microbiological laboratory evidence. Continuation of therapy was inappropriate in 5% of cases. By the intervention of the clinical pharmacist, colistin was discontinued in all patients in whom empirical therapy was continued incorrectly. None of the patients received loading dose of colistin. The maintenance dose, dose interval, and duration of treatment of colistin were appropriate in 76%, 71%, and 100% of patients, respectively. For none of the patients, the pharmacokinetic dosing method was used. In all patients, serum creatinine and WBC count were evaluated on daily basis. The sum indexes of colistin use were relevant to standard guidelines in 67.33% of the cases.Conclusion: The results of this study highlight the necessity of the pharmaceutical care team participation in all stages of treatment with antibiotics. After pharmacist interventions, some criteria of colistin utilization were corrected and brought closer to standard values. |
| first_indexed | 2024-04-12T16:22:35Z |
| format | Article |
| id | doaj.art-1623eb62fcdc4af781e7f28ef7360e60 |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-04-12T16:22:35Z |
| publishDate | 2017-09-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-1623eb62fcdc4af781e7f28ef7360e602022-12-22T03:25:31ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082017-09-017339139710.15171/apb.2017.047APB_16083_20170118181208Evaluating Adherence of Health-Care Team to Standard Guideline of Colistin Use at Intensive Care Units of a Referral Hospital in Shiraz, Southwest of IranAfsaneh Vazin0Iman Karimzadeh1Atiyeh Zand2Nazafarin Hatami-Mazinani3Dena Firouzabadi4Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Purpose: To evaluate colistin use according to global standard drug consumption in intensive care units of a referral hospital in Shiraz, Iran Methods: A prospective, interventional study was performed during an 11 month period on 100 patients admitted to ICUs of a teaching hospital being treated with colistin for at least 3 subsequent doses. Required demographic, clinical, and paraclinical data were gathered by a pharmacist. Fifteen indexes were considered to evaluate colistin use. A clinical pharmacist reviewed indication and dose of colistin at the time of prescribing this agent. Results: In our study population, pneumonia (69%) was the main indication of colistin. In 87% of patients, colistin administration was based on microbiological laboratory evidence. Continuation of therapy was inappropriate in 5% of cases. By the intervention of the clinical pharmacist, colistin was discontinued in all patients in whom empirical therapy was continued incorrectly. None of the patients received loading dose of colistin. The maintenance dose, dose interval, and duration of treatment of colistin were appropriate in 76%, 71%, and 100% of patients, respectively. For none of the patients, the pharmacokinetic dosing method was used. In all patients, serum creatinine and WBC count were evaluated on daily basis. The sum indexes of colistin use were relevant to standard guidelines in 67.33% of the cases.Conclusion: The results of this study highlight the necessity of the pharmaceutical care team participation in all stages of treatment with antibiotics. After pharmacist interventions, some criteria of colistin utilization were corrected and brought closer to standard values.http://journals.tbzmed.ac.ir/APB/Manuscript/APB-7-391.pdfColistin guidelineAdherenceClinical PharmacistIntensive care unit |
| spellingShingle | Afsaneh Vazin Iman Karimzadeh Atiyeh Zand Nazafarin Hatami-Mazinani Dena Firouzabadi Evaluating Adherence of Health-Care Team to Standard Guideline of Colistin Use at Intensive Care Units of a Referral Hospital in Shiraz, Southwest of Iran Advanced Pharmaceutical Bulletin Colistin guideline Adherence Clinical Pharmacist Intensive care unit |
| title | Evaluating Adherence of Health-Care Team to Standard Guideline of Colistin Use at Intensive Care Units of a Referral Hospital in Shiraz, Southwest of Iran |
| title_full | Evaluating Adherence of Health-Care Team to Standard Guideline of Colistin Use at Intensive Care Units of a Referral Hospital in Shiraz, Southwest of Iran |
| title_fullStr | Evaluating Adherence of Health-Care Team to Standard Guideline of Colistin Use at Intensive Care Units of a Referral Hospital in Shiraz, Southwest of Iran |
| title_full_unstemmed | Evaluating Adherence of Health-Care Team to Standard Guideline of Colistin Use at Intensive Care Units of a Referral Hospital in Shiraz, Southwest of Iran |
| title_short | Evaluating Adherence of Health-Care Team to Standard Guideline of Colistin Use at Intensive Care Units of a Referral Hospital in Shiraz, Southwest of Iran |
| title_sort | evaluating adherence of health care team to standard guideline of colistin use at intensive care units of a referral hospital in shiraz southwest of iran |
| topic | Colistin guideline Adherence Clinical Pharmacist Intensive care unit |
| url | http://journals.tbzmed.ac.ir/APB/Manuscript/APB-7-391.pdf |
| work_keys_str_mv | AT afsanehvazin evaluatingadherenceofhealthcareteamtostandardguidelineofcolistinuseatintensivecareunitsofareferralhospitalinshirazsouthwestofiran AT imankarimzadeh evaluatingadherenceofhealthcareteamtostandardguidelineofcolistinuseatintensivecareunitsofareferralhospitalinshirazsouthwestofiran AT atiyehzand evaluatingadherenceofhealthcareteamtostandardguidelineofcolistinuseatintensivecareunitsofareferralhospitalinshirazsouthwestofiran AT nazafarinhatamimazinani evaluatingadherenceofhealthcareteamtostandardguidelineofcolistinuseatintensivecareunitsofareferralhospitalinshirazsouthwestofiran AT denafirouzabadi evaluatingadherenceofhealthcareteamtostandardguidelineofcolistinuseatintensivecareunitsofareferralhospitalinshirazsouthwestofiran |