Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies
Biomphalaria alexandrina snails have received much attention due to their great medical importance as vectors for transmitting Schistosoma mansoni infection to humans. The main objective of the present work was to assess the efficacy of miltefosin a synthetic molluscicidal drug and artemether a natu...
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Format: | Article |
Language: | English |
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Sciendo
2020-11-01
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Series: | Helminthologia |
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Online Access: | https://doi.org/10.2478/helm-2020-0037 |
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author | Abdel-Azeem H. H. Osman G. Y. El Garhy M. F. Al Benasy K. S. |
author_facet | Abdel-Azeem H. H. Osman G. Y. El Garhy M. F. Al Benasy K. S. |
author_sort | Abdel-Azeem H. H. |
collection | DOAJ |
description | Biomphalaria alexandrina snails have received much attention due to their great medical importance as vectors for transmitting Schistosoma mansoni infection to humans. The main objective of the present work was to assess the efficacy of miltefosin a synthetic molluscicidal drug and artemether a natural molluscicidal drug. The correlation between immunological and histological observations from light and electron microscopy of the hemocytes of B. alexandrina post treatment with both drugs was also evaluated. LC50 and LC90 values were represented by 13.80 ppm and 24.40 ppm for miltefosine and 16.88 ppm and 27.97 ppm for artemether, respectively. The results showed that the treatment of S. mansoni-infected snails and normal snails with sublethal dose of miltefosine (LC25=8.20 ppm) and artemether (LC25=11.04 ppm) induced morphological abnormalities and a significant reduction in hemocytes count. |
first_indexed | 2024-03-12T09:22:52Z |
format | Article |
id | doaj.art-1627c2ba1e294eada02ce3262d1004d2 |
institution | Directory Open Access Journal |
issn | 1336-9083 |
language | English |
last_indexed | 2024-03-12T09:22:52Z |
publishDate | 2020-11-01 |
publisher | Sciendo |
record_format | Article |
series | Helminthologia |
spelling | doaj.art-1627c2ba1e294eada02ce3262d1004d22023-09-02T14:23:19ZengSciendoHelminthologia1336-90832020-11-0157433534310.2478/helm-2020-0037helm-2020-0037Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studiesAbdel-Azeem H. H.0Osman G. Y.1El Garhy M. F.2Al Benasy K. S.3Department of Zoology, Menoufia University, Shebeen El-koom, EgyptDepartment of Zoology, Menoufia University, Shebeen El-koom, EgyptDepartment of Zoology, Cairo University, Giza, EgyptDepartment of Zoology, Menoufia University, Shebeen El-koom, EgyptBiomphalaria alexandrina snails have received much attention due to their great medical importance as vectors for transmitting Schistosoma mansoni infection to humans. The main objective of the present work was to assess the efficacy of miltefosin a synthetic molluscicidal drug and artemether a natural molluscicidal drug. The correlation between immunological and histological observations from light and electron microscopy of the hemocytes of B. alexandrina post treatment with both drugs was also evaluated. LC50 and LC90 values were represented by 13.80 ppm and 24.40 ppm for miltefosine and 16.88 ppm and 27.97 ppm for artemether, respectively. The results showed that the treatment of S. mansoni-infected snails and normal snails with sublethal dose of miltefosine (LC25=8.20 ppm) and artemether (LC25=11.04 ppm) induced morphological abnormalities and a significant reduction in hemocytes count.https://doi.org/10.2478/helm-2020-0037biomphalaria alexandrinamiltefosineartemetherhemocytesimmunological and histological studieslight and electron microscope |
spellingShingle | Abdel-Azeem H. H. Osman G. Y. El Garhy M. F. Al Benasy K. S. Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies Helminthologia biomphalaria alexandrina miltefosine artemether hemocytes immunological and histological studies light and electron microscope |
title | Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies |
title_full | Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies |
title_fullStr | Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies |
title_full_unstemmed | Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies |
title_short | Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies |
title_sort | efficacy of miltefosine and artemether on infected biomphalaria alexandrina snails with schistosoma mansoni immunological and histological studies |
topic | biomphalaria alexandrina miltefosine artemether hemocytes immunological and histological studies light and electron microscope |
url | https://doi.org/10.2478/helm-2020-0037 |
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