Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies

Biomphalaria alexandrina snails have received much attention due to their great medical importance as vectors for transmitting Schistosoma mansoni infection to humans. The main objective of the present work was to assess the efficacy of miltefosin a synthetic molluscicidal drug and artemether a natu...

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Main Authors: Abdel-Azeem H. H., Osman G. Y., El Garhy M. F., Al Benasy K. S.
Format: Article
Language:English
Published: Sciendo 2020-11-01
Series:Helminthologia
Subjects:
Online Access:https://doi.org/10.2478/helm-2020-0037
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author Abdel-Azeem H. H.
Osman G. Y.
El Garhy M. F.
Al Benasy K. S.
author_facet Abdel-Azeem H. H.
Osman G. Y.
El Garhy M. F.
Al Benasy K. S.
author_sort Abdel-Azeem H. H.
collection DOAJ
description Biomphalaria alexandrina snails have received much attention due to their great medical importance as vectors for transmitting Schistosoma mansoni infection to humans. The main objective of the present work was to assess the efficacy of miltefosin a synthetic molluscicidal drug and artemether a natural molluscicidal drug. The correlation between immunological and histological observations from light and electron microscopy of the hemocytes of B. alexandrina post treatment with both drugs was also evaluated. LC50 and LC90 values were represented by 13.80 ppm and 24.40 ppm for miltefosine and 16.88 ppm and 27.97 ppm for artemether, respectively. The results showed that the treatment of S. mansoni-infected snails and normal snails with sublethal dose of miltefosine (LC25=8.20 ppm) and artemether (LC25=11.04 ppm) induced morphological abnormalities and a significant reduction in hemocytes count.
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spelling doaj.art-1627c2ba1e294eada02ce3262d1004d22023-09-02T14:23:19ZengSciendoHelminthologia1336-90832020-11-0157433534310.2478/helm-2020-0037helm-2020-0037Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studiesAbdel-Azeem H. H.0Osman G. Y.1El Garhy M. F.2Al Benasy K. S.3Department of Zoology, Menoufia University, Shebeen El-koom, EgyptDepartment of Zoology, Menoufia University, Shebeen El-koom, EgyptDepartment of Zoology, Cairo University, Giza, EgyptDepartment of Zoology, Menoufia University, Shebeen El-koom, EgyptBiomphalaria alexandrina snails have received much attention due to their great medical importance as vectors for transmitting Schistosoma mansoni infection to humans. The main objective of the present work was to assess the efficacy of miltefosin a synthetic molluscicidal drug and artemether a natural molluscicidal drug. The correlation between immunological and histological observations from light and electron microscopy of the hemocytes of B. alexandrina post treatment with both drugs was also evaluated. LC50 and LC90 values were represented by 13.80 ppm and 24.40 ppm for miltefosine and 16.88 ppm and 27.97 ppm for artemether, respectively. The results showed that the treatment of S. mansoni-infected snails and normal snails with sublethal dose of miltefosine (LC25=8.20 ppm) and artemether (LC25=11.04 ppm) induced morphological abnormalities and a significant reduction in hemocytes count.https://doi.org/10.2478/helm-2020-0037biomphalaria alexandrinamiltefosineartemetherhemocytesimmunological and histological studieslight and electron microscope
spellingShingle Abdel-Azeem H. H.
Osman G. Y.
El Garhy M. F.
Al Benasy K. S.
Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies
Helminthologia
biomphalaria alexandrina
miltefosine
artemether
hemocytes
immunological and histological studies
light and electron microscope
title Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies
title_full Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies
title_fullStr Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies
title_full_unstemmed Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies
title_short Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies
title_sort efficacy of miltefosine and artemether on infected biomphalaria alexandrina snails with schistosoma mansoni immunological and histological studies
topic biomphalaria alexandrina
miltefosine
artemether
hemocytes
immunological and histological studies
light and electron microscope
url https://doi.org/10.2478/helm-2020-0037
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