Comparing hand movement rate dependence of cerebral blood volume and BOLD responses at 7T
Functional magnetic resonance imaging (fMRI) based on the Blood Oxygenation Level Dependent (BOLD) contrast takes advantage of the coupling between neuronal activity and the hemodynamics to allow a non-invasive localisation of the neuronal activity. In general, fMRI experiments assume a linear relat...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-02-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811920311083 |
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| author | Ícaro A.F. de Oliveira Wietske van der Zwaag Luisa Raimondo Serge O. Dumoulin Jeroen C.W. Siero |
| author_facet | Ícaro A.F. de Oliveira Wietske van der Zwaag Luisa Raimondo Serge O. Dumoulin Jeroen C.W. Siero |
| author_sort | Ícaro A.F. de Oliveira |
| collection | DOAJ |
| description | Functional magnetic resonance imaging (fMRI) based on the Blood Oxygenation Level Dependent (BOLD) contrast takes advantage of the coupling between neuronal activity and the hemodynamics to allow a non-invasive localisation of the neuronal activity. In general, fMRI experiments assume a linear relationship between neuronal activation and the observed hemodynamics. However, the relationship between BOLD responses, neuronal activity, and behaviour are often nonlinear. In addition, the nonlinearity between BOLD responses and behaviour may be related to neuronal process rather than a neurovascular uncoupling. Further, part of the nonlinearity may be driven by vascular nonlinearity effects in particular from large vessel contributions. fMRI based on cerebral blood volume (CBV), promises a higher microvascular specificity, potentially without vascular nonlinearity effects and reduced contamination of the large draining vessels compared to BOLD. In this study, we aimed to investigate differences in BOLD and VASO-CBV signal changes during a hand movement task over a broad range of movement rates. We used a double readout 3D-EPI sequence at 7T to simultaneously measure VASO-CBV and BOLD responses in the sensorimotor cortex. The measured BOLD and VASO-CBV responses increased very similarly in a nonlinear fashion, plateauing for movement rates larger than 1 Hz. Our findings show a tight relationship between BOLD and VASO-CBV responses, indicating that the overall interplay of CBV and BOLD responses are similar for the assessed range of movement rates. These results suggest that the observed nonlinearity of neuronal origin is already present in VASO-CBV measurements, and consequently shows relatively unchanged BOLD responses. |
| first_indexed | 2024-12-22T06:50:20Z |
| format | Article |
| id | doaj.art-162a0a3c0a924eac849f6e90919b4815 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-22T06:50:20Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-162a0a3c0a924eac849f6e90919b48152022-12-21T18:35:10ZengElsevierNeuroImage1095-95722021-02-01226117623Comparing hand movement rate dependence of cerebral blood volume and BOLD responses at 7TÍcaro A.F. de Oliveira0Wietske van der Zwaag1Luisa Raimondo2Serge O. Dumoulin3Jeroen C.W. Siero4Spinoza Centre for Neuroimaging, Amsterdam, the Netherlands; Experimental and Applied Psychology, VU University, Amsterdam, the Netherlands; Corresponding author at: Spinoza Centre for Neuroimaging, Meibergdreef 75, 1105 BK Amsterdam, the Netherlands.Spinoza Centre for Neuroimaging, Amsterdam, the NetherlandsSpinoza Centre for Neuroimaging, Amsterdam, the Netherlands; Experimental and Applied Psychology, VU University, Amsterdam, the NetherlandsSpinoza Centre for Neuroimaging, Amsterdam, the Netherlands; Experimental and Applied Psychology, VU University, Amsterdam, the Netherlands; Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the NetherlandsSpinoza Centre for Neuroimaging, Amsterdam, the Netherlands; Radiology, Utrecht Center for Image Sciences, University Medical Center Utrecht, Utrecht, the NetherlandsFunctional magnetic resonance imaging (fMRI) based on the Blood Oxygenation Level Dependent (BOLD) contrast takes advantage of the coupling between neuronal activity and the hemodynamics to allow a non-invasive localisation of the neuronal activity. In general, fMRI experiments assume a linear relationship between neuronal activation and the observed hemodynamics. However, the relationship between BOLD responses, neuronal activity, and behaviour are often nonlinear. In addition, the nonlinearity between BOLD responses and behaviour may be related to neuronal process rather than a neurovascular uncoupling. Further, part of the nonlinearity may be driven by vascular nonlinearity effects in particular from large vessel contributions. fMRI based on cerebral blood volume (CBV), promises a higher microvascular specificity, potentially without vascular nonlinearity effects and reduced contamination of the large draining vessels compared to BOLD. In this study, we aimed to investigate differences in BOLD and VASO-CBV signal changes during a hand movement task over a broad range of movement rates. We used a double readout 3D-EPI sequence at 7T to simultaneously measure VASO-CBV and BOLD responses in the sensorimotor cortex. The measured BOLD and VASO-CBV responses increased very similarly in a nonlinear fashion, plateauing for movement rates larger than 1 Hz. Our findings show a tight relationship between BOLD and VASO-CBV responses, indicating that the overall interplay of CBV and BOLD responses are similar for the assessed range of movement rates. These results suggest that the observed nonlinearity of neuronal origin is already present in VASO-CBV measurements, and consequently shows relatively unchanged BOLD responses.http://www.sciencedirect.com/science/article/pii/S1053811920311083Vascular space occupancyVASOCerebral blood volumeBOLDNeurovascular couplingSensorimotor cortex |
| spellingShingle | Ícaro A.F. de Oliveira Wietske van der Zwaag Luisa Raimondo Serge O. Dumoulin Jeroen C.W. Siero Comparing hand movement rate dependence of cerebral blood volume and BOLD responses at 7T NeuroImage Vascular space occupancy VASO Cerebral blood volume BOLD Neurovascular coupling Sensorimotor cortex |
| title | Comparing hand movement rate dependence of cerebral blood volume and BOLD responses at 7T |
| title_full | Comparing hand movement rate dependence of cerebral blood volume and BOLD responses at 7T |
| title_fullStr | Comparing hand movement rate dependence of cerebral blood volume and BOLD responses at 7T |
| title_full_unstemmed | Comparing hand movement rate dependence of cerebral blood volume and BOLD responses at 7T |
| title_short | Comparing hand movement rate dependence of cerebral blood volume and BOLD responses at 7T |
| title_sort | comparing hand movement rate dependence of cerebral blood volume and bold responses at 7t |
| topic | Vascular space occupancy VASO Cerebral blood volume BOLD Neurovascular coupling Sensorimotor cortex |
| url | http://www.sciencedirect.com/science/article/pii/S1053811920311083 |
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