Mucosal immunization with Lactiplantibacillus plantarum-displaying recombinant SARS-CoV-2 epitopes on the surface induces humoral and mucosal immune responses in mice

Mucosal immunization with Lactiplantibacillus plantarum-displaying recombinant SARS-CoV-2 epitopes on the surface induces humoral and mucosal immune responses in mice

Abstract Background The use of probiotic lactic acid bacteria as a mucosal vaccine vector is considered a promising alternative compared to the use of other microorganisms because of its “Generally Regarded as Safe” status, its potential adjuvant properties, and its tolerogenicity to the host. Sever...

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Bibliographic Details
Main Authors: In-Chan Hwang, Valerie Diane Valeriano, Ji Hoon Song, Marcela Pereira, Ju Kyoung Oh, Kyudong Han, Lars Engstrand, Dae-Kyung Kang
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Microbial Cell Factories
Subjects:
Lactiplantibacillus plantarum
SARS-CoV-2
Mucosal delivery vector
Oral vaccine
Online Access:https://doi.org/10.1186/s12934-023-02100-7

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