Alpha-toxin induces programmed cell death of human T cells, B cells, and monocytes during USA300 infection.

Alpha-toxin induces programmed cell death of human T cells, B cells, and monocytes during USA300 infection.

This investigation examines the influence of alpha-toxin (Hla) during USA300 infection of human leukocytes. Survival of an USA300 isogenic deletion mutant of hla (USA300Δhla) in human blood was comparable to the parental wild-type strain and polymorphonuclear leukocyte (PMN) plasma membrane permeabi...

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Bibliographic Details
Main Authors: Tyler K Nygaard, Kyler B Pallister, Ashley L DuMont, Mark DeWald, Robert L Watkins, Erik Q Pallister, Cheryl Malone, Shannon Griffith, Alexander R Horswill, Victor J Torres, Jovanka M Voyich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3344897?pdf=render

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