Optoacoustic characterization of breast conserving surgery specimens – A pilot study
In this pilot study, we tested an ultrasound-guided optoacoustic tomography (US-OT) two-dimensional (2D) array scanner to understand the optoacoustic patterns of excised breastconserving surgery (BCS) specimens. We imaged 14 BCS specimens containing malignant tumors at eight wavelengths spanning 700...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Photoacoustics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597920300045 |
| _version_ | 1828858243667984384 |
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| author | Ghayathri Balasundaram Yonggeng Goh Mohesh Moothanchery Amalina Attia Hann Qian Lim Neal C. Burton Yi Qiu Thomas Choudary Putti Ching Wan Chan Mikael Hartmann Swee Tian Quek Malini Olivo |
| author_facet | Ghayathri Balasundaram Yonggeng Goh Mohesh Moothanchery Amalina Attia Hann Qian Lim Neal C. Burton Yi Qiu Thomas Choudary Putti Ching Wan Chan Mikael Hartmann Swee Tian Quek Malini Olivo |
| author_sort | Ghayathri Balasundaram |
| collection | DOAJ |
| description | In this pilot study, we tested an ultrasound-guided optoacoustic tomography (US-OT) two-dimensional (2D) array scanner to understand the optoacoustic patterns of excised breastconserving surgery (BCS) specimens. We imaged 14 BCS specimens containing malignant tumors at eight wavelengths spanning 700−1100 nm. Spectral unmixing across multiple wavelengths allowed for visualizing major intrinsic chromophores in the breast tissue including hemoglobin and lipid up to a depth of 7 mm. We identified less/no lipid signals within the tumor and intense deoxy-hemoglobin (Hb) signals on the rim of the tumor as unique characteristics of malignant tumors in comparison to no tumor region. We also observed continuous broad lipid signals as features of negative margins and compromised lipid signals interrupted by vasculature as features of positive margins. These differentiating patterns can form the basis of US-OT to be explored as an alternate, fast and efficient intraoperative method for evaluation of tumor resection margins. |
| first_indexed | 2024-12-13T01:53:52Z |
| format | Article |
| id | doaj.art-16307a6ade714a24902b731b7ca579a6 |
| institution | Directory Open Access Journal |
| issn | 2213-5979 |
| language | English |
| last_indexed | 2024-12-13T01:53:52Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj.art-16307a6ade714a24902b731b7ca579a62022-12-22T00:03:27ZengElsevierPhotoacoustics2213-59792020-09-0119100164Optoacoustic characterization of breast conserving surgery specimens – A pilot studyGhayathri Balasundaram0Yonggeng Goh1Mohesh Moothanchery2Amalina Attia3Hann Qian Lim4Neal C. Burton5Yi Qiu6Thomas Choudary Putti7Ching Wan Chan8Mikael Hartmann9Swee Tian Quek10Malini Olivo11Laboratory of Bio-Optical Imaging, Singapore Bioimaging Consortium, SingaporeDepartment of Diagnostic Imaging, National University Hospital, SingaporeLaboratory of Bio-Optical Imaging, Singapore Bioimaging Consortium, SingaporeLaboratory of Bio-Optical Imaging, Singapore Bioimaging Consortium, SingaporeLaboratory of Bio-Optical Imaging, Singapore Bioimaging Consortium, SingaporeiThera Medical GmbH, GermanyiThera Medical GmbH, GermanyDepartment of Pathology, National University Hospital, SingaporeDepartment of Breast Surgery, National University Hospital, SingaporeDepartment of Breast Surgery, National University Hospital, SingaporeDepartment of Diagnostic Imaging, National University Hospital, SingaporeLaboratory of Bio-Optical Imaging, Singapore Bioimaging Consortium, Singapore; Corresponding author at: Singapore Bioimaging Consortium (SBIC). A⁎STAR Research Entities, 11 Biopolis Way, #02-02 Helios, 138667, Singapore.In this pilot study, we tested an ultrasound-guided optoacoustic tomography (US-OT) two-dimensional (2D) array scanner to understand the optoacoustic patterns of excised breastconserving surgery (BCS) specimens. We imaged 14 BCS specimens containing malignant tumors at eight wavelengths spanning 700−1100 nm. Spectral unmixing across multiple wavelengths allowed for visualizing major intrinsic chromophores in the breast tissue including hemoglobin and lipid up to a depth of 7 mm. We identified less/no lipid signals within the tumor and intense deoxy-hemoglobin (Hb) signals on the rim of the tumor as unique characteristics of malignant tumors in comparison to no tumor region. We also observed continuous broad lipid signals as features of negative margins and compromised lipid signals interrupted by vasculature as features of positive margins. These differentiating patterns can form the basis of US-OT to be explored as an alternate, fast and efficient intraoperative method for evaluation of tumor resection margins.http://www.sciencedirect.com/science/article/pii/S2213597920300045Optoacoustic tomographyBreast-conserving surgeryResection marginUltrasound |
| spellingShingle | Ghayathri Balasundaram Yonggeng Goh Mohesh Moothanchery Amalina Attia Hann Qian Lim Neal C. Burton Yi Qiu Thomas Choudary Putti Ching Wan Chan Mikael Hartmann Swee Tian Quek Malini Olivo Optoacoustic characterization of breast conserving surgery specimens – A pilot study Photoacoustics Optoacoustic tomography Breast-conserving surgery Resection margin Ultrasound |
| title | Optoacoustic characterization of breast conserving surgery specimens – A pilot study |
| title_full | Optoacoustic characterization of breast conserving surgery specimens – A pilot study |
| title_fullStr | Optoacoustic characterization of breast conserving surgery specimens – A pilot study |
| title_full_unstemmed | Optoacoustic characterization of breast conserving surgery specimens – A pilot study |
| title_short | Optoacoustic characterization of breast conserving surgery specimens – A pilot study |
| title_sort | optoacoustic characterization of breast conserving surgery specimens a pilot study |
| topic | Optoacoustic tomography Breast-conserving surgery Resection margin Ultrasound |
| url | http://www.sciencedirect.com/science/article/pii/S2213597920300045 |
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