Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain
Increased low frequency cortical oscillations are observed in neuropathic pain. Here the authors perform Ca2+ imaging of DRG sensory neurons in a mouse model of neuropathic pain, and show that synchronized activity of DRG neurons occurs within hours after injury and 1-2 days before increased cortica...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36093-z |
| _version_ | 1828035085082820608 |
|---|---|
| author | Chao Chen Linlin Sun Avital Adler Hang Zhou Licheng Zhang Lihai Zhang Junhao Deng Yang Bai Jinhui Zhang Guang Yang Wen-Biao Gan Peifu Tang |
| author_facet | Chao Chen Linlin Sun Avital Adler Hang Zhou Licheng Zhang Lihai Zhang Junhao Deng Yang Bai Jinhui Zhang Guang Yang Wen-Biao Gan Peifu Tang |
| author_sort | Chao Chen |
| collection | DOAJ |
| description | Increased low frequency cortical oscillations are observed in neuropathic pain. Here the authors perform Ca2+ imaging of DRG sensory neurons in a mouse model of neuropathic pain, and show that synchronized activity of DRG neurons occurs within hours after injury and 1-2 days before increased cortical oscillations are observed. |
| first_indexed | 2024-04-10T15:42:59Z |
| format | Article |
| id | doaj.art-16315f9ebae34c5b96867363e7991c44 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T15:42:59Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-16315f9ebae34c5b96867363e7991c442023-02-12T12:17:24ZengNature PortfolioNature Communications2041-17232023-02-0114111410.1038/s41467-023-36093-zSynchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic painChao Chen0Linlin Sun1Avital Adler2Hang Zhou3Licheng Zhang4Lihai Zhang5Junhao Deng6Yang Bai7Jinhui Zhang8Guang Yang9Wen-Biao Gan10Peifu Tang11Department of Orthopaedics, Peking 301 HospitalDepartment of Anesthesiology, Columbia University Medical CenterSkirball Institute, Department of Neuroscience and Physiology, New York University School of MedicineDepartment of Anesthesiology, Columbia University Medical CenterDepartment of Orthopaedics, Peking 301 HospitalDepartment of Orthopaedics, Peking 301 HospitalDepartment of Orthopaedics, Peking 301 HospitalInstitute of Neurological and Psychiatric Disorders, Shenzhen Bay LaboratoryDepartment of Orthopaedics, the Affiliated Southeast Hospital of Xiamen UniversityDepartment of Anesthesiology, Columbia University Medical CenterInstitute of Neurological and Psychiatric Disorders, Shenzhen Bay LaboratoryDepartment of Orthopaedics, Peking 301 HospitalIncreased low frequency cortical oscillations are observed in neuropathic pain. Here the authors perform Ca2+ imaging of DRG sensory neurons in a mouse model of neuropathic pain, and show that synchronized activity of DRG neurons occurs within hours after injury and 1-2 days before increased cortical oscillations are observed.https://doi.org/10.1038/s41467-023-36093-z |
| spellingShingle | Chao Chen Linlin Sun Avital Adler Hang Zhou Licheng Zhang Lihai Zhang Junhao Deng Yang Bai Jinhui Zhang Guang Yang Wen-Biao Gan Peifu Tang Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain Nature Communications |
| title | Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain |
| title_full | Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain |
| title_fullStr | Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain |
| title_full_unstemmed | Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain |
| title_short | Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain |
| title_sort | synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain |
| url | https://doi.org/10.1038/s41467-023-36093-z |
| work_keys_str_mv | AT chaochen synchronizedactivityofsensoryneuronsinitiatescorticalsynchronyinamodelofneuropathicpain AT linlinsun synchronizedactivityofsensoryneuronsinitiatescorticalsynchronyinamodelofneuropathicpain AT avitaladler synchronizedactivityofsensoryneuronsinitiatescorticalsynchronyinamodelofneuropathicpain AT hangzhou synchronizedactivityofsensoryneuronsinitiatescorticalsynchronyinamodelofneuropathicpain AT lichengzhang synchronizedactivityofsensoryneuronsinitiatescorticalsynchronyinamodelofneuropathicpain AT lihaizhang synchronizedactivityofsensoryneuronsinitiatescorticalsynchronyinamodelofneuropathicpain AT junhaodeng synchronizedactivityofsensoryneuronsinitiatescorticalsynchronyinamodelofneuropathicpain AT yangbai synchronizedactivityofsensoryneuronsinitiatescorticalsynchronyinamodelofneuropathicpain AT jinhuizhang synchronizedactivityofsensoryneuronsinitiatescorticalsynchronyinamodelofneuropathicpain AT guangyang synchronizedactivityofsensoryneuronsinitiatescorticalsynchronyinamodelofneuropathicpain AT wenbiaogan synchronizedactivityofsensoryneuronsinitiatescorticalsynchronyinamodelofneuropathicpain AT peifutang synchronizedactivityofsensoryneuronsinitiatescorticalsynchronyinamodelofneuropathicpain |