Resistant starch-rich wx/ae brown rice prevents insulin resistance and hypertriglyceridaemia in type 2 diabetic NSY mice
A rice cultivar called ‘wx/ae’, double mutant in waxy (wx) and amylose extender (ae) genes, is rich in resistant starch. Type 2 diabetic NSY mice were fed a test diet containing 30% roasted wx/ae brown rice (wx/ae group) or its parental rice cultivar Kinmaze brown rice (WT group) for 16 weeks. The i...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-05-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464616000621 |
| _version_ | 1818563044971642880 |
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| author | Kenji Matsumoto Eri Yasuyoshi Kurumi Nishi Yuji Honda Makoto Nakaya Shinichi Kitamura |
| author_facet | Kenji Matsumoto Eri Yasuyoshi Kurumi Nishi Yuji Honda Makoto Nakaya Shinichi Kitamura |
| author_sort | Kenji Matsumoto |
| collection | DOAJ |
| description | A rice cultivar called ‘wx/ae’, double mutant in waxy (wx) and amylose extender (ae) genes, is rich in resistant starch. Type 2 diabetic NSY mice were fed a test diet containing 30% roasted wx/ae brown rice (wx/ae group) or its parental rice cultivar Kinmaze brown rice (WT group) for 16 weeks. The insulin sensitivity of the wx/ae group was significantly higher than that of the WT group, and the concentrations of fasting plasma triacylglycerol and non-esterified fatty acids were lower. Gene expression analysis of the liver revealed that expression levels of insulin-dependent genes and bile acid-related genes in the two groups were significantly different. Moreover, expression of the G protein-coupled receptor 43 gene in the epididymal white adipose tissue was significantly higher in the wx/ae group. These results indicate that wx/ae brown rice is a good candidate food for the prevention of type 2 diabetes and hypertriglyceridaemia. |
| first_indexed | 2024-12-14T01:11:42Z |
| format | Article |
| id | doaj.art-163181e81ca948878f9f7b13c256140e |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T01:11:42Z |
| publishDate | 2016-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-163181e81ca948878f9f7b13c256140e2022-12-21T23:22:43ZengElsevierJournal of Functional Foods1756-46462016-05-0123556564Resistant starch-rich wx/ae brown rice prevents insulin resistance and hypertriglyceridaemia in type 2 diabetic NSY miceKenji Matsumoto0Eri Yasuyoshi1Kurumi Nishi2Yuji Honda3Makoto Nakaya4Shinichi Kitamura5Department of Food Science, Ishikawa Prefectural University, 1-308 Suematsu, Nonoichi, Ishikawa 921-8836, Japan; Corresponding author. Department of Food Science, Ishikawa Prefectural University, 1-308 Suematsu, Nonoichi, Ishikawa 921-8836, Japan. Tel.: +81 76 227 7458; fax: +81 76 227 7458.Department of Food Science, Ishikawa Prefectural University, 1-308 Suematsu, Nonoichi, Ishikawa 921-8836, JapanDepartment of Food Science, Ishikawa Prefectural University, 1-308 Suematsu, Nonoichi, Ishikawa 921-8836, JapanDepartment of Food Science, Ishikawa Prefectural University, 1-308 Suematsu, Nonoichi, Ishikawa 921-8836, JapanGraduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1 Gakuencho, Sakai, Osaka 599-8531, JapanGraduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1 Gakuencho, Sakai, Osaka 599-8531, JapanA rice cultivar called ‘wx/ae’, double mutant in waxy (wx) and amylose extender (ae) genes, is rich in resistant starch. Type 2 diabetic NSY mice were fed a test diet containing 30% roasted wx/ae brown rice (wx/ae group) or its parental rice cultivar Kinmaze brown rice (WT group) for 16 weeks. The insulin sensitivity of the wx/ae group was significantly higher than that of the WT group, and the concentrations of fasting plasma triacylglycerol and non-esterified fatty acids were lower. Gene expression analysis of the liver revealed that expression levels of insulin-dependent genes and bile acid-related genes in the two groups were significantly different. Moreover, expression of the G protein-coupled receptor 43 gene in the epididymal white adipose tissue was significantly higher in the wx/ae group. These results indicate that wx/ae brown rice is a good candidate food for the prevention of type 2 diabetes and hypertriglyceridaemia.http://www.sciencedirect.com/science/article/pii/S1756464616000621wx/ae riceResistant starchInsulin resistanceHypertriglyceridaemiaType 2 diabetes |
| spellingShingle | Kenji Matsumoto Eri Yasuyoshi Kurumi Nishi Yuji Honda Makoto Nakaya Shinichi Kitamura Resistant starch-rich wx/ae brown rice prevents insulin resistance and hypertriglyceridaemia in type 2 diabetic NSY mice Journal of Functional Foods wx/ae rice Resistant starch Insulin resistance Hypertriglyceridaemia Type 2 diabetes |
| title | Resistant starch-rich wx/ae brown rice prevents insulin resistance and hypertriglyceridaemia in type 2 diabetic NSY mice |
| title_full | Resistant starch-rich wx/ae brown rice prevents insulin resistance and hypertriglyceridaemia in type 2 diabetic NSY mice |
| title_fullStr | Resistant starch-rich wx/ae brown rice prevents insulin resistance and hypertriglyceridaemia in type 2 diabetic NSY mice |
| title_full_unstemmed | Resistant starch-rich wx/ae brown rice prevents insulin resistance and hypertriglyceridaemia in type 2 diabetic NSY mice |
| title_short | Resistant starch-rich wx/ae brown rice prevents insulin resistance and hypertriglyceridaemia in type 2 diabetic NSY mice |
| title_sort | resistant starch rich wx ae brown rice prevents insulin resistance and hypertriglyceridaemia in type 2 diabetic nsy mice |
| topic | wx/ae rice Resistant starch Insulin resistance Hypertriglyceridaemia Type 2 diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S1756464616000621 |
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