Role of Neuroglobin in the Neuroprotective Actions of Estradiol and Estrogenic Compounds
Estradiol exerts neuroprotective actions that are mediated by the regulation of a variety of signaling pathways and homeostatic molecules. Among these is neuroglobin, which is upregulated by estradiol and translocated to the mitochondria to sustain neuronal and glial cell adaptation to injury. In th...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/8/1907 |
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| author | George E. Barreto Andrew J. McGovern Luis M. Garcia-Segura |
| author_facet | George E. Barreto Andrew J. McGovern Luis M. Garcia-Segura |
| author_sort | George E. Barreto |
| collection | DOAJ |
| description | Estradiol exerts neuroprotective actions that are mediated by the regulation of a variety of signaling pathways and homeostatic molecules. Among these is neuroglobin, which is upregulated by estradiol and translocated to the mitochondria to sustain neuronal and glial cell adaptation to injury. In this paper, we will discuss the role of neuroglobin in the neuroprotective mechanisms elicited by estradiol acting on neurons, astrocytes and microglia. We will also consider the role of neuroglobin in the neuroprotective actions of clinically relevant synthetic steroids, such as tibolone. Finally, the possible contribution of the estrogenic regulation of neuroglobin to the generation of sex differences in brain pathology and the potential application of neuroglobin as therapy against neurological diseases will be examined. |
| first_indexed | 2024-03-10T08:55:13Z |
| format | Article |
| id | doaj.art-1632df81cbe7421c95275cb0ca31f081 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T08:55:13Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-1632df81cbe7421c95275cb0ca31f0812023-11-22T07:09:01ZengMDPI AGCells2073-44092021-07-01108190710.3390/cells10081907Role of Neuroglobin in the Neuroprotective Actions of Estradiol and Estrogenic CompoundsGeorge E. Barreto0Andrew J. McGovern1Luis M. Garcia-Segura2Department of Biological Sciences, University of Limerick, V94 T9PX Limerick, IrelandDepartment of Biological Sciences, University of Limerick, V94 T9PX Limerick, IrelandInstituto Cajal, Consejo Superior de Investigaciones Científicas (C.S.I.C.), 28002 Madrid, SpainEstradiol exerts neuroprotective actions that are mediated by the regulation of a variety of signaling pathways and homeostatic molecules. Among these is neuroglobin, which is upregulated by estradiol and translocated to the mitochondria to sustain neuronal and glial cell adaptation to injury. In this paper, we will discuss the role of neuroglobin in the neuroprotective mechanisms elicited by estradiol acting on neurons, astrocytes and microglia. We will also consider the role of neuroglobin in the neuroprotective actions of clinically relevant synthetic steroids, such as tibolone. Finally, the possible contribution of the estrogenic regulation of neuroglobin to the generation of sex differences in brain pathology and the potential application of neuroglobin as therapy against neurological diseases will be examined.https://www.mdpi.com/2073-4409/10/8/1907astrocytesestrogen receptorsmicrogliamitochondrianeuronsex differences |
| spellingShingle | George E. Barreto Andrew J. McGovern Luis M. Garcia-Segura Role of Neuroglobin in the Neuroprotective Actions of Estradiol and Estrogenic Compounds Cells astrocytes estrogen receptors microglia mitochondria neuron sex differences |
| title | Role of Neuroglobin in the Neuroprotective Actions of Estradiol and Estrogenic Compounds |
| title_full | Role of Neuroglobin in the Neuroprotective Actions of Estradiol and Estrogenic Compounds |
| title_fullStr | Role of Neuroglobin in the Neuroprotective Actions of Estradiol and Estrogenic Compounds |
| title_full_unstemmed | Role of Neuroglobin in the Neuroprotective Actions of Estradiol and Estrogenic Compounds |
| title_short | Role of Neuroglobin in the Neuroprotective Actions of Estradiol and Estrogenic Compounds |
| title_sort | role of neuroglobin in the neuroprotective actions of estradiol and estrogenic compounds |
| topic | astrocytes estrogen receptors microglia mitochondria neuron sex differences |
| url | https://www.mdpi.com/2073-4409/10/8/1907 |
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