Calcium during cardiac arrest: A systematic review
Aim: To perform a systematic review of administration of calcium compared to no calcium during cardiac arrest. Methods: The search included Medline (PubMed), Embase, Cochrane, Web of Science, and CINAHL Plus and was conducted on September 30, 2022. The population included adults and children in any...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Resuscitation Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266652042300022X |
| _version_ | 1827977159378993152 |
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| author | Cindy H. Hsu Keith Couper Tyler Nix Ian Drennan Joshua Reynolds Monica Kleinman Katherine M. Berg |
| author_facet | Cindy H. Hsu Keith Couper Tyler Nix Ian Drennan Joshua Reynolds Monica Kleinman Katherine M. Berg |
| author_sort | Cindy H. Hsu |
| collection | DOAJ |
| description | Aim: To perform a systematic review of administration of calcium compared to no calcium during cardiac arrest. Methods: The search included Medline (PubMed), Embase, Cochrane, Web of Science, and CINAHL Plus and was conducted on September 30, 2022. The population included adults and children in any setting with cardiac arrest. The outcomes included return of spontaneous circulation, survival, survival with favourable neurologic outcome to hospital discharge and 30 days or longer, and quality of life outcome. Cochrane Risk of Bias 2 and ROBINS-I were performed to assess risk of bias for controlled and observational studies, respectively. Results: The systematic review identified 4 studies on 3 randomised controlled trials on 554 adult out-of-hospital cardiac arrest (OHCA) patients, 8 observational studies on 2,731 adult cardiac arrest patients, and 3 observational studies on 17,449 paediatric in-hospital cardiac arrest (IHCA) patients. The randomised controlled and observational studies showed that routine calcium administration during cardiac arrest did not improve the outcome of adult OHCA or IHCA or paediatric IHCA. The risk of bias for the adult trials was low for one recent trial and high for two earlier trials, with randomization as the primary source of bias. The risk of bias for the individual observational studies was assessed to be critical due to confounding. The certainty of evidence was assessed to be moderate for adult OHCA and low for adult and paediatric IHCA. Heterogeneity across studies precluded any meaningful meta-analyses. Conclusions: This systematic review found no evidence that routine calcium administration improves the outcomes of cardiac arrest in adults or children.PROSPERO Registration: CRD42022349641. |
| first_indexed | 2024-04-09T21:00:26Z |
| format | Article |
| id | doaj.art-1634020d6ff4433997a7e7262ac1f863 |
| institution | Directory Open Access Journal |
| issn | 2666-5204 |
| language | English |
| last_indexed | 2024-04-09T21:00:26Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Resuscitation Plus |
| spelling | doaj.art-1634020d6ff4433997a7e7262ac1f8632023-03-29T09:30:12ZengElsevierResuscitation Plus2666-52042023-06-0114100379Calcium during cardiac arrest: A systematic reviewCindy H. Hsu0Keith Couper1Tyler Nix2Ian Drennan3Joshua Reynolds4Monica Kleinman5Katherine M. Berg6Department of Emergency Medicine, Weil Institute for Critical Care Research and Innovation, and Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Corresponding author at: Department of Emergency Medicine, University of Michigan Medical School, NCRC B026-309N, 2800 Plymouth Road, Ann Arbor, MI 48109-2800, USA.Warwick Medical School, University of Warwick, Coventry and Critical Care Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United KingdomTaubman Health Sciences Library, University of Michigan, USASunnybrook Research Institute, Sunnybrook Health Science Centre, CanadaMichigan State University, Grand Rapids, MI, USADepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USACenter for Resuscitation Science, Department of Medicine, Division of Pulmonary Critical Care, Beth Israel Deaconess Medical Center, Boston, MA, USAAim: To perform a systematic review of administration of calcium compared to no calcium during cardiac arrest. Methods: The search included Medline (PubMed), Embase, Cochrane, Web of Science, and CINAHL Plus and was conducted on September 30, 2022. The population included adults and children in any setting with cardiac arrest. The outcomes included return of spontaneous circulation, survival, survival with favourable neurologic outcome to hospital discharge and 30 days or longer, and quality of life outcome. Cochrane Risk of Bias 2 and ROBINS-I were performed to assess risk of bias for controlled and observational studies, respectively. Results: The systematic review identified 4 studies on 3 randomised controlled trials on 554 adult out-of-hospital cardiac arrest (OHCA) patients, 8 observational studies on 2,731 adult cardiac arrest patients, and 3 observational studies on 17,449 paediatric in-hospital cardiac arrest (IHCA) patients. The randomised controlled and observational studies showed that routine calcium administration during cardiac arrest did not improve the outcome of adult OHCA or IHCA or paediatric IHCA. The risk of bias for the adult trials was low for one recent trial and high for two earlier trials, with randomization as the primary source of bias. The risk of bias for the individual observational studies was assessed to be critical due to confounding. The certainty of evidence was assessed to be moderate for adult OHCA and low for adult and paediatric IHCA. Heterogeneity across studies precluded any meaningful meta-analyses. Conclusions: This systematic review found no evidence that routine calcium administration improves the outcomes of cardiac arrest in adults or children.PROSPERO Registration: CRD42022349641.http://www.sciencedirect.com/science/article/pii/S266652042300022XAdvanced Life SupportBasic Life SupportCardiac ArrestCalciumSystematic ReviewILCOR |
| spellingShingle | Cindy H. Hsu Keith Couper Tyler Nix Ian Drennan Joshua Reynolds Monica Kleinman Katherine M. Berg Calcium during cardiac arrest: A systematic review Resuscitation Plus Advanced Life Support Basic Life Support Cardiac Arrest Calcium Systematic Review ILCOR |
| title | Calcium during cardiac arrest: A systematic review |
| title_full | Calcium during cardiac arrest: A systematic review |
| title_fullStr | Calcium during cardiac arrest: A systematic review |
| title_full_unstemmed | Calcium during cardiac arrest: A systematic review |
| title_short | Calcium during cardiac arrest: A systematic review |
| title_sort | calcium during cardiac arrest a systematic review |
| topic | Advanced Life Support Basic Life Support Cardiac Arrest Calcium Systematic Review ILCOR |
| url | http://www.sciencedirect.com/science/article/pii/S266652042300022X |
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