Trefoil factor family peptides – friends or foes?
Trefoil factor family (TFF) peptides are a group of molecules bearing a characteristic three-loop trefoil domain. They are mainly secreted in mucous epithelia together with mucins but are also synthesized in the nervous system. For many years, TFF peptides were only known for their wound healing and...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2015-12-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc-2015-0020 |
| _version_ | 1819137434404782080 |
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| author | Busch Maike Dünker Nicole |
| author_facet | Busch Maike Dünker Nicole |
| author_sort | Busch Maike |
| collection | DOAJ |
| description | Trefoil factor family (TFF) peptides are a group of molecules bearing a characteristic three-loop trefoil domain. They are mainly secreted in mucous epithelia together with mucins but are also synthesized in the nervous system. For many years, TFF peptides were only known for their wound healing and protective function, e.g. in epithelial protection and restitution. However, experimental evidence has emerged supporting a pivotal role of TFF peptides in oncogenic transformation, tumorigenesis and metastasis. Deregulated expression of TFF peptides at the gene and protein level is obviously implicated in numerous cancers, and opposing functions as oncogenes and tumor suppressors have been described. With regard to the regulation of TFF expression, epigenetic mechanisms as well as the involvement of various miRNAs are new, promising aspects in the field of cancer research. This review will summarize current knowledge about the expression and regulation of TFF peptides and the involvement of TFF peptides in tumor biology and cancerogenesis. |
| first_indexed | 2024-12-22T10:50:49Z |
| format | Article |
| id | doaj.art-1635b553234e48bfbf71159121ad825e |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-12-22T10:50:49Z |
| publishDate | 2015-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-1635b553234e48bfbf71159121ad825e2022-12-21T18:28:46ZengDe GruyterBiomolecular Concepts1868-50211868-503X2015-12-0165-634335910.1515/bmc-2015-0020Trefoil factor family peptides – friends or foes?Busch Maike0Dünker Nicole1Medical Faculty, Institute for Anatomy II, Department of Neuroanatomy, University of Duisburg-Essen, Hufelandstr. 55, D-45122 Essen, GermanyMedical Faculty, Institute for Anatomy II, Department of Neuroanatomy, University of Duisburg-Essen, Hufelandstr. 55, D-45122 Essen, GermanyTrefoil factor family (TFF) peptides are a group of molecules bearing a characteristic three-loop trefoil domain. They are mainly secreted in mucous epithelia together with mucins but are also synthesized in the nervous system. For many years, TFF peptides were only known for their wound healing and protective function, e.g. in epithelial protection and restitution. However, experimental evidence has emerged supporting a pivotal role of TFF peptides in oncogenic transformation, tumorigenesis and metastasis. Deregulated expression of TFF peptides at the gene and protein level is obviously implicated in numerous cancers, and opposing functions as oncogenes and tumor suppressors have been described. With regard to the regulation of TFF expression, epigenetic mechanisms as well as the involvement of various miRNAs are new, promising aspects in the field of cancer research. This review will summarize current knowledge about the expression and regulation of TFF peptides and the involvement of TFF peptides in tumor biology and cancerogenesis.https://doi.org/10.1515/bmc-2015-0020cancerexpressionregulationsignalingtrefoil factor family |
| spellingShingle | Busch Maike Dünker Nicole Trefoil factor family peptides – friends or foes? Biomolecular Concepts cancer expression regulation signaling trefoil factor family |
| title | Trefoil factor family peptides – friends or foes? |
| title_full | Trefoil factor family peptides – friends or foes? |
| title_fullStr | Trefoil factor family peptides – friends or foes? |
| title_full_unstemmed | Trefoil factor family peptides – friends or foes? |
| title_short | Trefoil factor family peptides – friends or foes? |
| title_sort | trefoil factor family peptides friends or foes |
| topic | cancer expression regulation signaling trefoil factor family |
| url | https://doi.org/10.1515/bmc-2015-0020 |
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