A Study of Alternative TrkA Splicing Identifies TrkAIII as a Novel Potentially Targetable Participant in PitNET Progression

A Study of Alternative TrkA Splicing Identifies TrkAIII as a Novel Potentially Targetable Participant in PitNET Progression

Pituitary neuroendocrine tumors (PitNETs) are generally benign but comprise an aggressive, invasive, therapy-resistant, metastatic subset, underpinning a need for novel therapeutic targets. PitNETs exhibit low mutation rates but are associated with conditions linked to alternative splicing, an alter...

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Bibliographic Details
Main Authors: Maddalena Sbaffone, Marie-Lise Jaffrain-Rea, Lucia Cappabianca, Francesca Carbonara, Francesca Gianno, Tiziana Feola, Marianna Ruggieri, Veronica Zelli, Rita Maccarone, Stefano Guadagni, Marco Clementi, Antonietta Arcella, Vincenzo Esposito, Giulia Carozza, Ilaria Martelli, Antonietta Rosella Farina, Andrew Reay Mackay
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Biology
Subjects:
PitNETs
alternative splicing
<i>TrkAIII</i> splice variant
HIF2α
splice factors SF3B1, U2AF and SRSF2
hotspot SF3B1 mutation
Online Access:https://www.mdpi.com/2079-7737/13/3/171

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