Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability
As a drug delivery system, ketoconazole microemulsion in virgin coconut oil (oil phase) is added with a thickening agent to create transdermal dosage form. This study aimed to compare the physical stabilities of ketoconazole microemulsions formed with different thickeners, namely Carbopol 934 and Ca...
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| Format: | Article |
| Language: | English |
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Universitas Ahmad Dahlan
2018-05-01
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| Series: | Pharmaciana |
| Subjects: | |
| Online Access: | http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/9138/pdf_74 |
| _version_ | 1798027307860885504 |
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| author | Pramulani Mulya Lestari Kori Yati Nanda Savira |
| author_facet | Pramulani Mulya Lestari Kori Yati Nanda Savira |
| author_sort | Pramulani Mulya Lestari |
| collection | DOAJ |
| description | As a drug delivery system, ketoconazole microemulsion in virgin coconut oil (oil phase) is added with a thickening agent to create transdermal dosage form. This study aimed to compare the physical stabilities of ketoconazole microemulsions formed with different thickeners, namely Carbopol 934 and Carbopol 941. The formula used varying concentrations of Carbopol 934 and Carbopol 941, i.e., 0.15% and 0.25%. The stability was observed during eight-week storage in which the conditions were controlled by different degrees of temperature, i.e., 40C, 25-300C (room temperature), and 400C. The stability tests included organoleptic observation, pH, surface tension, viscosity, particle size, and zeta potential. Based on the Kruskal-Wallis test results, ketoconazole microemulsion with Carbopol 941 that had been stored in different temperature showed a significant difference in particle size (significance value< 0.05), but it did not apply to Carbopol 934. The evaluation revealed that compared to 0.25% of Carbopol 934, microemulsion with 0.15% of Carbopol 934 had a smaller difference between the time intervals. This research concluded that the use of 0.15% of Carbopol 934 as a thickener in ketoconazole microemulsion had better physical stability compared to Carbopol 941 due to the influence of temperature and length of storage. |
| first_indexed | 2024-04-11T18:50:27Z |
| format | Article |
| id | doaj.art-163982eccdb34101a45dffef77232eb7 |
| institution | Directory Open Access Journal |
| issn | 2088-4559 2477-0256 |
| language | English |
| last_indexed | 2024-04-11T18:50:27Z |
| publishDate | 2018-05-01 |
| publisher | Universitas Ahmad Dahlan |
| record_format | Article |
| series | Pharmaciana |
| spelling | doaj.art-163982eccdb34101a45dffef77232eb72022-12-22T04:08:26ZengUniversitas Ahmad DahlanPharmaciana2088-45592477-02562018-05-018111912810.12928/pharmaciana.v8i1.9138Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stabilityPramulani Mulya Lestari0Kori Yati1Nanda Savira2Fakultas Farmasi dan Sains, Universitas Muhammadiyah Prof. DR. HAMKAFakultas Farmasi dan Sains, Universitas Muhammadiyah Prof. DR. HAMKAFakultas Farmasi dan Sains, Universitas Muhammadiyah Prof. DR. HAMKAAs a drug delivery system, ketoconazole microemulsion in virgin coconut oil (oil phase) is added with a thickening agent to create transdermal dosage form. This study aimed to compare the physical stabilities of ketoconazole microemulsions formed with different thickeners, namely Carbopol 934 and Carbopol 941. The formula used varying concentrations of Carbopol 934 and Carbopol 941, i.e., 0.15% and 0.25%. The stability was observed during eight-week storage in which the conditions were controlled by different degrees of temperature, i.e., 40C, 25-300C (room temperature), and 400C. The stability tests included organoleptic observation, pH, surface tension, viscosity, particle size, and zeta potential. Based on the Kruskal-Wallis test results, ketoconazole microemulsion with Carbopol 941 that had been stored in different temperature showed a significant difference in particle size (significance value< 0.05), but it did not apply to Carbopol 934. The evaluation revealed that compared to 0.25% of Carbopol 934, microemulsion with 0.15% of Carbopol 934 had a smaller difference between the time intervals. This research concluded that the use of 0.15% of Carbopol 934 as a thickener in ketoconazole microemulsion had better physical stability compared to Carbopol 941 due to the influence of temperature and length of storage.http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/9138/pdf_74physical stabilityketoconazole microemulsionthickenercarbopol 934and carbopol 941 |
| spellingShingle | Pramulani Mulya Lestari Kori Yati Nanda Savira Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability Pharmaciana physical stability ketoconazole microemulsion thickener carbopol 934 and carbopol 941 |
| title | Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability |
| title_full | Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability |
| title_fullStr | Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability |
| title_full_unstemmed | Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability |
| title_short | Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability |
| title_sort | comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability |
| topic | physical stability ketoconazole microemulsion thickener carbopol 934 and carbopol 941 |
| url | http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/9138/pdf_74 |
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