Dynamics of hepatic gene expression and serum cytokine profiles in single and double-hit burn and sepsis animal models
We simulate the pathophysiology of severe burn trauma and burn-induced sepsis, using rat models of experimental burn injury and cecal ligation and puncture (CLP) either individually (singe-hit model) or in combination (double-hit model). The experimental burn injury simulates a systemic but sterile...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-06-01
|
| Series: | Data in Brief |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340915000293 |
| _version_ | 1818477744874323968 |
|---|---|
| author | Rohit Rao Mehmet A. Orman Francois Berthiaume Ioannis P. Androulakis |
| author_facet | Rohit Rao Mehmet A. Orman Francois Berthiaume Ioannis P. Androulakis |
| author_sort | Rohit Rao |
| collection | DOAJ |
| description | We simulate the pathophysiology of severe burn trauma and burn-induced sepsis, using rat models of experimental burn injury and cecal ligation and puncture (CLP) either individually (singe-hit model) or in combination (double-hit model). The experimental burn injury simulates a systemic but sterile pro-inflammatory response, while the CLP simulates the effect of polymicrobial sepsis. Given the liver׳s central role in mediating the host immune response and onset of hypermetabolism after burn injury, elucidating the alterations in hepatic gene expression in response to injury can lead to a better understanding of the regulation of the inflammatory response, whereas circulating cytokine protein expression, reflects key systemic inflammatory mediators. In this article, we present both the hepatic gene expression and circulating cytokine/chemokine protein expression data for the above-mentioned experimental model to gain insights into the temporal dynamics of the inflammatory and hypermetabolic response following burn and septic injury. This data article supports results discussed in research articles (Yang et al., 2012 [1,4]; Mattick et al. 2012, 2013 [2,3]; Nguyen et al., 2014 [5]; Orman et al., 2011, 2012 [6–8]). |
| first_indexed | 2024-12-10T09:40:57Z |
| format | Article |
| id | doaj.art-163a160a5a76456f92e88b98fde37716 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-10T09:40:57Z |
| publishDate | 2015-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-163a160a5a76456f92e88b98fde377162022-12-22T01:53:59ZengElsevierData in Brief2352-34092015-06-013C22923310.1016/j.dib.2015.02.018Dynamics of hepatic gene expression and serum cytokine profiles in single and double-hit burn and sepsis animal modelsRohit Rao0Mehmet A. Orman1Francois Berthiaume2Ioannis P. Androulakis3Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USAChemical and Biological Engineering Department, Princeton University, Princeton, NJ 08544, USADepartment of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USADepartment of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USAWe simulate the pathophysiology of severe burn trauma and burn-induced sepsis, using rat models of experimental burn injury and cecal ligation and puncture (CLP) either individually (singe-hit model) or in combination (double-hit model). The experimental burn injury simulates a systemic but sterile pro-inflammatory response, while the CLP simulates the effect of polymicrobial sepsis. Given the liver׳s central role in mediating the host immune response and onset of hypermetabolism after burn injury, elucidating the alterations in hepatic gene expression in response to injury can lead to a better understanding of the regulation of the inflammatory response, whereas circulating cytokine protein expression, reflects key systemic inflammatory mediators. In this article, we present both the hepatic gene expression and circulating cytokine/chemokine protein expression data for the above-mentioned experimental model to gain insights into the temporal dynamics of the inflammatory and hypermetabolic response following burn and septic injury. This data article supports results discussed in research articles (Yang et al., 2012 [1,4]; Mattick et al. 2012, 2013 [2,3]; Nguyen et al., 2014 [5]; Orman et al., 2011, 2012 [6–8]).http://www.sciencedirect.com/science/article/pii/S2352340915000293BurnCecal ligation and punctureChemokinesCytokinesHepatic gene expressionInflammatory responseMicroarray analysis |
| spellingShingle | Rohit Rao Mehmet A. Orman Francois Berthiaume Ioannis P. Androulakis Dynamics of hepatic gene expression and serum cytokine profiles in single and double-hit burn and sepsis animal models Data in Brief Burn Cecal ligation and puncture Chemokines Cytokines Hepatic gene expression Inflammatory response Microarray analysis |
| title | Dynamics of hepatic gene expression and serum cytokine profiles in single and double-hit burn and sepsis animal models |
| title_full | Dynamics of hepatic gene expression and serum cytokine profiles in single and double-hit burn and sepsis animal models |
| title_fullStr | Dynamics of hepatic gene expression and serum cytokine profiles in single and double-hit burn and sepsis animal models |
| title_full_unstemmed | Dynamics of hepatic gene expression and serum cytokine profiles in single and double-hit burn and sepsis animal models |
| title_short | Dynamics of hepatic gene expression and serum cytokine profiles in single and double-hit burn and sepsis animal models |
| title_sort | dynamics of hepatic gene expression and serum cytokine profiles in single and double hit burn and sepsis animal models |
| topic | Burn Cecal ligation and puncture Chemokines Cytokines Hepatic gene expression Inflammatory response Microarray analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2352340915000293 |
| work_keys_str_mv | AT rohitrao dynamicsofhepaticgeneexpressionandserumcytokineprofilesinsingleanddoublehitburnandsepsisanimalmodels AT mehmetaorman dynamicsofhepaticgeneexpressionandserumcytokineprofilesinsingleanddoublehitburnandsepsisanimalmodels AT francoisberthiaume dynamicsofhepaticgeneexpressionandserumcytokineprofilesinsingleanddoublehitburnandsepsisanimalmodels AT ioannispandroulakis dynamicsofhepaticgeneexpressionandserumcytokineprofilesinsingleanddoublehitburnandsepsisanimalmodels |