Self-Control of Inflammation during Tail Regeneration of Lizards
Lizards can spontaneously regenerate their lost tail without evoking excessive inflammation at the damaged site. In contrast, tissue/organ injury of its mammalian counterparts results in wound healing with a formation of a fibrotic scar due to uncontrolled activation of inflammatory responses. Unvei...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Journal of Developmental Biology |
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| Online Access: | https://www.mdpi.com/2221-3759/9/4/48 |
| _version_ | 1797503358279352320 |
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| author | Bingqiang He Honghua Song Yongjun Wang |
| author_facet | Bingqiang He Honghua Song Yongjun Wang |
| author_sort | Bingqiang He |
| collection | DOAJ |
| description | Lizards can spontaneously regenerate their lost tail without evoking excessive inflammation at the damaged site. In contrast, tissue/organ injury of its mammalian counterparts results in wound healing with a formation of a fibrotic scar due to uncontrolled activation of inflammatory responses. Unveiling the mechanism of self-limited inflammation occurring in the regeneration of a lizard tail will provide clues for a therapeutic alternative to tissue injury. The present review provides an overview of aspects of rapid wound healing and roles of antibacterial peptides, effects of leukocytes on the tail regeneration, self-blocking of the inflammatory activation in leukocytes, as well as inflammatory resistance of blastemal cells or immature somatic cells during lizard tail regeneration. These mechanistic insights of self-control of inflammation during lizard tail regeneration may lead in the future to the development of therapeutic strategies to fight injury-induced inflammation. |
| first_indexed | 2024-03-10T03:49:28Z |
| format | Article |
| id | doaj.art-163a96379cd441139696e449c52599b8 |
| institution | Directory Open Access Journal |
| issn | 2221-3759 |
| language | English |
| last_indexed | 2024-03-10T03:49:28Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Developmental Biology |
| spelling | doaj.art-163a96379cd441139696e449c52599b82023-11-23T08:59:37ZengMDPI AGJournal of Developmental Biology2221-37592021-11-01944810.3390/jdb9040048Self-Control of Inflammation during Tail Regeneration of LizardsBingqiang He0Honghua Song1Yongjun Wang2Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong 226001, ChinaKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong 226001, ChinaKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong 226001, ChinaLizards can spontaneously regenerate their lost tail without evoking excessive inflammation at the damaged site. In contrast, tissue/organ injury of its mammalian counterparts results in wound healing with a formation of a fibrotic scar due to uncontrolled activation of inflammatory responses. Unveiling the mechanism of self-limited inflammation occurring in the regeneration of a lizard tail will provide clues for a therapeutic alternative to tissue injury. The present review provides an overview of aspects of rapid wound healing and roles of antibacterial peptides, effects of leukocytes on the tail regeneration, self-blocking of the inflammatory activation in leukocytes, as well as inflammatory resistance of blastemal cells or immature somatic cells during lizard tail regeneration. These mechanistic insights of self-control of inflammation during lizard tail regeneration may lead in the future to the development of therapeutic strategies to fight injury-induced inflammation.https://www.mdpi.com/2221-3759/9/4/48lizardregenerationappendageblastemal cellsinflammation |
| spellingShingle | Bingqiang He Honghua Song Yongjun Wang Self-Control of Inflammation during Tail Regeneration of Lizards Journal of Developmental Biology lizard regeneration appendage blastemal cells inflammation |
| title | Self-Control of Inflammation during Tail Regeneration of Lizards |
| title_full | Self-Control of Inflammation during Tail Regeneration of Lizards |
| title_fullStr | Self-Control of Inflammation during Tail Regeneration of Lizards |
| title_full_unstemmed | Self-Control of Inflammation during Tail Regeneration of Lizards |
| title_short | Self-Control of Inflammation during Tail Regeneration of Lizards |
| title_sort | self control of inflammation during tail regeneration of lizards |
| topic | lizard regeneration appendage blastemal cells inflammation |
| url | https://www.mdpi.com/2221-3759/9/4/48 |
| work_keys_str_mv | AT bingqianghe selfcontrolofinflammationduringtailregenerationoflizards AT honghuasong selfcontrolofinflammationduringtailregenerationoflizards AT yongjunwang selfcontrolofinflammationduringtailregenerationoflizards |