Association of serum growth differentiation factor-15 with eGFR and hemoglobin in healthy older females
Purpose: Anemia and sarcopenia associated with renal dysfunction caused by cytokine imbalance can contribute to decreased quality of life for older individuals. Growth differentiation factor-15 (GDF-15) is associated with renal dysfunction, although whether it is related to anemia or sarcopenia is u...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906720303493 |
| _version_ | 1818726739510034432 |
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| author | Hiroko Yazawa Taira Fukuda Hiroyuki Kaneda Ryutaro Waku Masashi Sakuma Akihiro Matsumoto Shigeru Toyoda Shichiro Abe Fumitaka Nakamura Teruo Inoue Toshiaki Nakajima |
| author_facet | Hiroko Yazawa Taira Fukuda Hiroyuki Kaneda Ryutaro Waku Masashi Sakuma Akihiro Matsumoto Shigeru Toyoda Shichiro Abe Fumitaka Nakamura Teruo Inoue Toshiaki Nakajima |
| author_sort | Hiroko Yazawa |
| collection | DOAJ |
| description | Purpose: Anemia and sarcopenia associated with renal dysfunction caused by cytokine imbalance can contribute to decreased quality of life for older individuals. Growth differentiation factor-15 (GDF-15) is associated with renal dysfunction, although whether it is related to anemia or sarcopenia is unclear. In this study we examined the association of GDF-15 with renal function, hemoglobin and sarcopenia in healthy community-dwelling older females in Japan. Methods: A total of 66 healthy older community-dwelling females (age: 75.8 ± 6.2 years) were enrolled for this study. Skeletal muscle mass index was determined by bioelectrical impedance analysis. Hand-grip strength and walking speed were also assessed. Serum GDF-15 concentration was determined by enzyme-linked immunosorbent assay and both hemoglobin (Hb) level and estimated glomerular filtration rate (eGFR) were measured. Results: Serum GDF-15 levels positively correlated with age but negatively correlated with eGFR and walking speed. In multiple regression analysis, eGFR and hemoglobin (Hb) were independent variables to predict serum GDF-15 levels, even after adjusting for age and body mass index (eGFR: β = −0.423, p < 0.001; Hb: β = −0.363, p = 0.004). Serum GDF-15 level was an independent variable to predict eGFR and Hb. Conclusions: Both Hb and eGFR are predictors for serum GDF-15 concentration in healthy older females. In these community-dwelling older females, renal dysfunction via GDF-15 may be accompanied by anemia, but not sarcopenia. |
| first_indexed | 2024-12-17T22:03:00Z |
| format | Article |
| id | doaj.art-163bfa9cab73487cac71cf69aba3934a |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-12-17T22:03:00Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-163bfa9cab73487cac71cf69aba3934a2022-12-21T21:30:55ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672020-12-0131100651Association of serum growth differentiation factor-15 with eGFR and hemoglobin in healthy older femalesHiroko Yazawa0Taira Fukuda1Hiroyuki Kaneda2Ryutaro Waku3Masashi Sakuma4Akihiro Matsumoto5Shigeru Toyoda6Shichiro Abe7Fumitaka Nakamura8Teruo Inoue9Toshiaki Nakajima10Department of Cardiovascular Medicine, Dokkyo Medical University and Heart Center, Dokkyo Medical University Hospital, Tochigi, JapanDepartment of Liberal Arts and Human Development, Kanagawa University of Human Services, Kanagawa, Japan; Corresponding author.Department of Cardiovascular Medicine, Dokkyo Medical University and Heart Center, Dokkyo Medical University Hospital, Tochigi, JapanDepartment of Cardiovascular Medicine, Dokkyo Medical University and Heart Center, Dokkyo Medical University Hospital, Tochigi, JapanDepartment of Cardiovascular Medicine, Dokkyo Medical University and Heart Center, Dokkyo Medical University Hospital, Tochigi, JapanDepartment of Food and Nutrition, Faculty of Human Life, Jumonji University, Saitama, JapanDepartment of Cardiovascular Medicine, Dokkyo Medical University and Heart Center, Dokkyo Medical University Hospital, Tochigi, JapanDepartment of Cardiovascular Medicine, Dokkyo Medical University and Heart Center, Dokkyo Medical University Hospital, Tochigi, JapanThird Department of Internal Medicine, Teikyo University, Chiba Medical Center, JapanDepartment of Cardiovascular Medicine, Dokkyo Medical University and Heart Center, Dokkyo Medical University Hospital, Tochigi, JapanDepartment of Cardiovascular Medicine, Dokkyo Medical University and Heart Center, Dokkyo Medical University Hospital, Tochigi, JapanPurpose: Anemia and sarcopenia associated with renal dysfunction caused by cytokine imbalance can contribute to decreased quality of life for older individuals. Growth differentiation factor-15 (GDF-15) is associated with renal dysfunction, although whether it is related to anemia or sarcopenia is unclear. In this study we examined the association of GDF-15 with renal function, hemoglobin and sarcopenia in healthy community-dwelling older females in Japan. Methods: A total of 66 healthy older community-dwelling females (age: 75.8 ± 6.2 years) were enrolled for this study. Skeletal muscle mass index was determined by bioelectrical impedance analysis. Hand-grip strength and walking speed were also assessed. Serum GDF-15 concentration was determined by enzyme-linked immunosorbent assay and both hemoglobin (Hb) level and estimated glomerular filtration rate (eGFR) were measured. Results: Serum GDF-15 levels positively correlated with age but negatively correlated with eGFR and walking speed. In multiple regression analysis, eGFR and hemoglobin (Hb) were independent variables to predict serum GDF-15 levels, even after adjusting for age and body mass index (eGFR: β = −0.423, p < 0.001; Hb: β = −0.363, p = 0.004). Serum GDF-15 level was an independent variable to predict eGFR and Hb. Conclusions: Both Hb and eGFR are predictors for serum GDF-15 concentration in healthy older females. In these community-dwelling older females, renal dysfunction via GDF-15 may be accompanied by anemia, but not sarcopenia.http://www.sciencedirect.com/science/article/pii/S2352906720303493Community-dwelling older femalesGDF-15HemoglobinRenal function |
| spellingShingle | Hiroko Yazawa Taira Fukuda Hiroyuki Kaneda Ryutaro Waku Masashi Sakuma Akihiro Matsumoto Shigeru Toyoda Shichiro Abe Fumitaka Nakamura Teruo Inoue Toshiaki Nakajima Association of serum growth differentiation factor-15 with eGFR and hemoglobin in healthy older females International Journal of Cardiology: Heart & Vasculature Community-dwelling older females GDF-15 Hemoglobin Renal function |
| title | Association of serum growth differentiation factor-15 with eGFR and hemoglobin in healthy older females |
| title_full | Association of serum growth differentiation factor-15 with eGFR and hemoglobin in healthy older females |
| title_fullStr | Association of serum growth differentiation factor-15 with eGFR and hemoglobin in healthy older females |
| title_full_unstemmed | Association of serum growth differentiation factor-15 with eGFR and hemoglobin in healthy older females |
| title_short | Association of serum growth differentiation factor-15 with eGFR and hemoglobin in healthy older females |
| title_sort | association of serum growth differentiation factor 15 with egfr and hemoglobin in healthy older females |
| topic | Community-dwelling older females GDF-15 Hemoglobin Renal function |
| url | http://www.sciencedirect.com/science/article/pii/S2352906720303493 |
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