Angiogenesis in Regenerative Dentistry: Are We Far Enough for Therapy?
Angiogenesis is a broad spread term of high interest in regenerative medicine and tissue engineering including the dental field. In the last two decades, researchers worldwide struggled to find the best ways to accelerate healing, stimulate soft, and hard tissue remodeling. Stem cells, growth factor...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/2/929 |
| _version_ | 1797410003481526272 |
|---|---|
| author | Oana Baru Andreea Nutu Cornelia Braicu Cosmin Andrei Cismaru Ioana Berindan-Neagoe Smaranda Buduru Mîndra Badea |
| author_facet | Oana Baru Andreea Nutu Cornelia Braicu Cosmin Andrei Cismaru Ioana Berindan-Neagoe Smaranda Buduru Mîndra Badea |
| author_sort | Oana Baru |
| collection | DOAJ |
| description | Angiogenesis is a broad spread term of high interest in regenerative medicine and tissue engineering including the dental field. In the last two decades, researchers worldwide struggled to find the best ways to accelerate healing, stimulate soft, and hard tissue remodeling. Stem cells, growth factors, pathways, signals, receptors, genetics are just a few words that describe this area in medicine. Dental implants, bone and soft tissue regeneration using autologous grafts, or xenografts, allografts, their integration and acceptance rely on their material properties. However, the host response, through its vascularization, plays a significant role. The present paper aims to analyze and organize the latest information about the available dental stem cells, the types of growth factors with pro-angiogenic effect and the possible therapeutic effect of enhanced angiogenesis in regenerative dentistry. |
| first_indexed | 2024-03-09T04:23:34Z |
| format | Article |
| id | doaj.art-163cb43eec8546f888d40e5d7aa83c7f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:23:34Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-163cb43eec8546f888d40e5d7aa83c7f2023-12-03T13:43:42ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-0122292910.3390/ijms22020929Angiogenesis in Regenerative Dentistry: Are We Far Enough for Therapy?Oana Baru0Andreea Nutu1Cornelia Braicu2Cosmin Andrei Cismaru3Ioana Berindan-Neagoe4Smaranda Buduru5Mîndra Badea6Department of Preventive Dentistry, Faculty of Dental Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400083 Cluj-Napoca, RomaniaResearch Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400015 Cluj-Napoca, RomaniaResearch Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400015 Cluj-Napoca, RomaniaResearch Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400015 Cluj-Napoca, RomaniaResearch Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400015 Cluj-Napoca, RomaniaStomestet Stomatology Clinic, Calea Manastur 68A Street, 400658 Cluj-Napoca, RomaniaDepartment of Preventive Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, Avram Iancu 31, 400083 Cluj-Napoca, RomaniaAngiogenesis is a broad spread term of high interest in regenerative medicine and tissue engineering including the dental field. In the last two decades, researchers worldwide struggled to find the best ways to accelerate healing, stimulate soft, and hard tissue remodeling. Stem cells, growth factors, pathways, signals, receptors, genetics are just a few words that describe this area in medicine. Dental implants, bone and soft tissue regeneration using autologous grafts, or xenografts, allografts, their integration and acceptance rely on their material properties. However, the host response, through its vascularization, plays a significant role. The present paper aims to analyze and organize the latest information about the available dental stem cells, the types of growth factors with pro-angiogenic effect and the possible therapeutic effect of enhanced angiogenesis in regenerative dentistry.https://www.mdpi.com/1422-0067/22/2/929angiogenesismesenchymal stem cellsdental stem cellstissue regenerationdental implants |
| spellingShingle | Oana Baru Andreea Nutu Cornelia Braicu Cosmin Andrei Cismaru Ioana Berindan-Neagoe Smaranda Buduru Mîndra Badea Angiogenesis in Regenerative Dentistry: Are We Far Enough for Therapy? International Journal of Molecular Sciences angiogenesis mesenchymal stem cells dental stem cells tissue regeneration dental implants |
| title | Angiogenesis in Regenerative Dentistry: Are We Far Enough for Therapy? |
| title_full | Angiogenesis in Regenerative Dentistry: Are We Far Enough for Therapy? |
| title_fullStr | Angiogenesis in Regenerative Dentistry: Are We Far Enough for Therapy? |
| title_full_unstemmed | Angiogenesis in Regenerative Dentistry: Are We Far Enough for Therapy? |
| title_short | Angiogenesis in Regenerative Dentistry: Are We Far Enough for Therapy? |
| title_sort | angiogenesis in regenerative dentistry are we far enough for therapy |
| topic | angiogenesis mesenchymal stem cells dental stem cells tissue regeneration dental implants |
| url | https://www.mdpi.com/1422-0067/22/2/929 |
| work_keys_str_mv | AT oanabaru angiogenesisinregenerativedentistryarewefarenoughfortherapy AT andreeanutu angiogenesisinregenerativedentistryarewefarenoughfortherapy AT corneliabraicu angiogenesisinregenerativedentistryarewefarenoughfortherapy AT cosminandreicismaru angiogenesisinregenerativedentistryarewefarenoughfortherapy AT ioanaberindanneagoe angiogenesisinregenerativedentistryarewefarenoughfortherapy AT smarandabuduru angiogenesisinregenerativedentistryarewefarenoughfortherapy AT mindrabadea angiogenesisinregenerativedentistryarewefarenoughfortherapy |