LIM domain‐containing protein Ajuba inhibits chemotherapy‐induced apoptosis by negatively regulating p53 stability in colorectal cancer cells

LIM domain‐containing protein Ajuba inhibits chemotherapy‐induced apoptosis by negatively regulating p53 stability in colorectal cancer cells

LIM protein‐domain containing protein Ajuba (encoded by AJUBA) functions as a scaffold protein to regulate protein–protein interactions, signalling transduction and genes transcription. AJUBA expression is higher in colorectal cancer (CRC) tissues than normal tissues, but its specific molecular func...

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Bibliographic Details
Main Authors: Beihui Xu, Qi Li, Jianjun Zhang, Fuxiang Chen
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Molecular Oncology
Subjects:
Ajuba
apoptosis
chemoresistance
colorectal cancer
p53
Online Access:https://doi.org/10.1002/1878-0261.13421

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