Genetic polymorphism and their contribution to cancer susceptibility
Since the majority of chemical carcinogens are not capable of causing hazardous effects per se, the metabolism of these compounds is a crucial part of the initial host response to the environmental exposure. Disturbances in the balance between activation and detoxification may thus explain the indiv...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
1998-01-01
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| Series: | Cadernos de Saúde Pública |
| Subjects: | |
| Online Access: | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1998000700002 |
| _version_ | 1818290284386058240 |
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| author | Conforti-Froes Nívea El-Zein Randa Au William |
| author_facet | Conforti-Froes Nívea El-Zein Randa Au William |
| author_sort | Conforti-Froes Nívea |
| collection | DOAJ |
| description | Since the majority of chemical carcinogens are not capable of causing hazardous effects per se, the metabolism of these compounds is a crucial part of the initial host response to the environmental exposure. Disturbances in the balance between activation and detoxification may thus explain the individual variations in responses to exposures to carcinogens. The amount of the ultimate carcinogen produced depends on the action of competing activation and detoxification pathways involving cytochrome P450 and glutathione-S-transferases enzymes. |
| first_indexed | 2024-12-13T02:25:43Z |
| format | Article |
| id | doaj.art-163d0daf9ca447689bc0b792b99192a0 |
| institution | Directory Open Access Journal |
| issn | 0102-311X 1678-4464 |
| language | English |
| last_indexed | 2024-12-13T02:25:43Z |
| publishDate | 1998-01-01 |
| publisher | Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz |
| record_format | Article |
| series | Cadernos de Saúde Pública |
| spelling | doaj.art-163d0daf9ca447689bc0b792b99192a02022-12-22T00:02:38ZengEscola Nacional de Saúde Pública, Fundação Oswaldo CruzCadernos de Saúde Pública0102-311X1678-44641998-01-0114suppl.30713Genetic polymorphism and their contribution to cancer susceptibilityConforti-Froes NíveaEl-Zein RandaAu WilliamSince the majority of chemical carcinogens are not capable of causing hazardous effects per se, the metabolism of these compounds is a crucial part of the initial host response to the environmental exposure. Disturbances in the balance between activation and detoxification may thus explain the individual variations in responses to exposures to carcinogens. The amount of the ultimate carcinogen produced depends on the action of competing activation and detoxification pathways involving cytochrome P450 and glutathione-S-transferases enzymes.http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1998000700002Polymorphism/GeneticsNeoplasmMolecular Epidemiology |
| spellingShingle | Conforti-Froes Nívea El-Zein Randa Au William Genetic polymorphism and their contribution to cancer susceptibility Cadernos de Saúde Pública Polymorphism/Genetics Neoplasm Molecular Epidemiology |
| title | Genetic polymorphism and their contribution to cancer susceptibility |
| title_full | Genetic polymorphism and their contribution to cancer susceptibility |
| title_fullStr | Genetic polymorphism and their contribution to cancer susceptibility |
| title_full_unstemmed | Genetic polymorphism and their contribution to cancer susceptibility |
| title_short | Genetic polymorphism and their contribution to cancer susceptibility |
| title_sort | genetic polymorphism and their contribution to cancer susceptibility |
| topic | Polymorphism/Genetics Neoplasm Molecular Epidemiology |
| url | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1998000700002 |
| work_keys_str_mv | AT confortifroesnivea geneticpolymorphismandtheircontributiontocancersusceptibility AT elzeinranda geneticpolymorphismandtheircontributiontocancersusceptibility AT auwilliam geneticpolymorphismandtheircontributiontocancersusceptibility |