Human Engineered Heart Tissue Models for Disease Modeling and Drug Discovery

Human Engineered Heart Tissue Models for Disease Modeling and Drug Discovery

The emergence of human induced pluripotent stem cells (hiPSCs) and efficient differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased donors have the potential to recapitulate the molecular and functional features of the human heart. Although the immaturity of hiPSC-CMs, inc...

Full description

Bibliographic Details
Main Authors:	Hidenori Tani, Shugo Tohyama
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-03-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	engineered heart tissues (EHTs) human induced pluripotent stem cells (iPS cells) (hiPSCs) tissue engieering disease model drug discovery cardiotoxicity
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2022.855763/full

Similar Items

Induced pluripotent stem cell-based models: Are we ready for that heart in a dish?
by: Irene Bissoli, et al.
Published: (2023-01-01)

High-efficient serum-free differentiation of endothelial cells from human iPS cells
by: Sarkawt Hamad, et al.
Published: (2022-06-01)

From bedside to the bench: patient-specific hiPSC-EC models uncover endothelial dysfunction in genetic cardiomyopathies
by: Martina Rabino, et al.
Published: (2023-07-01)

Development of an In Vitro Blood Vessel Model Using Autologous Endothelial Cells Generated from Footprint-Free hiPSCs to Analyze Interactions of the Endothelium with Blood Cell Components and Vascular Implants
by: Josefin Weber, et al.
Published: (2023-04-01)

Generation of iPSC-Derived Human Peripheral Sensory Neurons Releasing Substance P Elicited by TRPV1 Agonists
by: Marília Z. P. Guimarães, et al.
Published: (2018-08-01)

Induction of Neural Crest Stem Cells From Bardet–Biedl Syndrome Patient Derived hiPSCs
by: William B. Barrell, et al.
Published: (2019-06-01)

Optimized serial expansion of human induced pluripotent stem cells using low‐density inoculation to generate clinically relevant quantities in vertical‐wheel bioreactors
by: Breanna S. Borys, et al.
Published: (2020-09-01)

A Comparative Study of Cell Culture Conditions during Conversion from Primed to Naive Human Pluripotent Stem Cells
by: Irene Romayor, et al.
Published: (2022-06-01)

Activation of AMPK Promotes Maturation of Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells
by: Liang Ye, et al.
Published: (2021-03-01)

Infection of human induced pluripotent stem cells by an oncogenic herpesvirus
by: Jiaojiao Fan, et al.
Published: (2025-03-01)

Single cell transfection of human-induced pluripotent stem cells using a droplet-based microfluidic system
by: Camilo Pérez-Sosa, et al.
Published: (2022-01-01)

Toward Human Models of Cardiorenal Syndrome in vitro
by: Beatrice Gabbin, et al.
Published: (2022-05-01)

PTEN-induced putative kinase 1 regulates mitochondrial quality control and is essential for the maturation of human induced pluripotent stem cell-derived cardiomyocytes
by: Huiwen Liu, et al.
Published: (2023-09-01)

Application of CRISPR/Cas9 to human-induced pluripotent stem cells: from gene editing to drug discovery
by: Claudia De Masi, et al.
Published: (2020-06-01)

METTL1-mediated m7G methylation maintains pluripotency in human stem cells and limits mesoderm differentiation and vascular development
by: Yujie Deng, et al.
Published: (2020-07-01)

Enhanced efficiency of generating human-induced pluripotent stem cells using Lin28-30Kc19 fusion protein
by: Boram Son, et al.
Published: (2022-07-01)

Generation of muscle progenitors from human-induced pluripotent stem cells
by: Ibrahim Elmadbouh
Published: (2022-07-01)

Unlocking the Pragmatic Potential of Regenerative Therapies in Heart Failure with Next-Generation Treatments
by: Yoshikazu Kishino, et al.
Published: (2023-03-01)

TMEM182 inhibits myocardial differentiation of human iPS cells by maintaining the activated state of Wnt/β‐catenin signaling through an increase in ILK expression
by: Hirofumi Morihara, et al.
Published: (2024-11-01)

Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal model
by: Chun Tang, et al.
Published: (2025-02-01)

Characterizing the secretome of licensed hiPSC-derived MSCs
by: Yolande F. M. Ramos, et al.
Published: (2022-09-01)

Patient-derived cornea organoid model to study metabolomic characterization of rare disease: aniridia-associated keratopathy
by: Ali Can Koc, et al.
Published: (2025-01-01)

Neuronal Differentiation from Induced Pluripotent Stem Cell-Derived Neurospheres by the Application of Oxidized Alginate-Gelatin-Laminin Hydrogels
by: Thomas Distler, et al.
Published: (2021-03-01)

Editorial: Bioengineering and Biotechnology Approaches in Cardiovascular Sciences
by: Jianyi Zhang, et al.
Published: (2021-08-01)

Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
by: Tobias Mothes, et al.
Published: (2023-06-01)

Induced Pluripotent Stem Cells, a Stepping Stone to In Vitro Human Models of Hearing Loss
by: María Beatriz Durán-Alonso, et al.
Published: (2022-10-01)

DP71 and SERCA2 alteration in human neurons of a Duchenne muscular dystrophy patient
by: Simona Ruggieri, et al.
Published: (2019-01-01)

Induced pluripotent stem (iPS) cells and somatic cardiac regeneration — An exploratory bioinformatic analysis
by: Robert Chen, et al.
Published: (2016-04-01)

Editorial: Advances in pluripotent stem cell-based in vitro models of the human heart for cardiac physiology, disease modeling and clinical applications
by: Maksymilian Prondzynski, et al.
Published: (2024-02-01)

One Billion hiPSC-Cardiomyocytes: Upscaling Engineered Cardiac Tissues to Create High Cell Density Therapies for Clinical Translation in Heart Regeneration
by: Kiera D. Dwyer, et al.
Published: (2023-05-01)

May I Cut in? Gene Editing Approaches in Human Induced Pluripotent Stem Cells
by: Nicholas Brookhouser, et al.
Published: (2017-02-01)

Modelling Diabetic Cardiomyopathy: Using Human Stem Cell-Derived Cardiomyocytes to Complement Animal Models
by: Ujang Purnama, et al.
Published: (2022-09-01)

Advances in the Generation of Constructed Cardiac Tissue Derived from Induced Pluripotent Stem Cells for Disease Modeling and Therapeutic Discovery
by: Truman J. Roland, et al.
Published: (2024-01-01)

Cardiac tissue engineering: Multiple approaches and potential applications
by: Ilaria Gisone, et al.
Published: (2022-10-01)

Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain Aging
by: Chuan-Chuan Chao, et al.
Published: (2021-11-01)

Urine Sample-Derived Cerebral Organoids Suitable for Studying Neurodevelopment and Pharmacological Responses
by: Victor J. T. Lin, et al.
Published: (2020-05-01)

Generation of two induced pluripotent stem cell lines from hereditary amyloidosis patients with polyneuropathy carrying heterozygous transthyretin (TTR) mutation
by: Juan Melesio, et al.
Published: (2024-02-01)

Glycan Epitopes on 201B7 Human-Induced Pluripotent Stem Cells Using R-10G and R-17F Marker Antibodies
by: Yuko Nagai, et al.
Published: (2021-03-01)

Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques
by: Pranav Preman, et al.
Published: (2021-09-01)

Retinal organoids with X-linked retinoschisis RS1 (E72K) mutation exhibit a photoreceptor developmental delay and are rescued by gene augmentation therapy
by: Chunwen Duan, et al.
Published: (2024-05-01)