Estimation of serum uric acid in patients of acute myocardial infarction
BACKGROUND: Acute myocardial infarction (AMI), often known as a heart attack, is a medical emergency that is the top cause of mortality for both men and women worldwide. Recent evidence suggests that it is caused by the sudden blockage of a coronary artery by a blood clot, also known as coronary thr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Health Sciences and Biomedical Research KLEU |
| Subjects: | |
| Online Access: | http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2023;volume=16;issue=1;spage=111;epage=114;aulast=Mishra |
| _version_ | 1797904892417802240 |
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| author | Devendra Nath Mishra Rajesh Kumar Singh Hari Prasad Anuj Dwivedi |
| author_facet | Devendra Nath Mishra Rajesh Kumar Singh Hari Prasad Anuj Dwivedi |
| author_sort | Devendra Nath Mishra |
| collection | DOAJ |
| description | BACKGROUND: Acute myocardial infarction (AMI), often known as a heart attack, is a medical emergency that is the top cause of mortality for both men and women worldwide. Recent evidence suggests that it is caused by the sudden blockage of a coronary artery by a blood clot, also known as coronary thrombosis. Due to the regional impending of blood supply, heart muscles become damaged. Uric acid has been shown in large cohort studies to be an important independent risk factor for cardiovascular mortality. As serum uric acid (SUA) is an early predictor hence study will help to devise a better remedy for AMI.
AIM: This study aims to study the levels of SUA in patients with AMI as compared to the control.
OBJECTIVE: The primary goal of this study is to examine SUA levels in patients with AMI and to correlate uric acid levels with associated mortality in AMI. The secondary goal is to predict AMI early diagnosis, better management and treatment, and prognosis.
METHODS: The current study was conducted at the department of biochemistry and the central investigation laboratory at our institute, in partnership with the department of medicine, intense cardiac care units, medical intensive care units, and emergency and private hospitals. A total of 100 patients were investigated. There were 50 instances of AMI and 50 age-matched healthy controls. The Microlab 300 analyzers (semi-autoanalyzer) were used to assess SUA concentrations, and the comparisons between the two groups were examined using an unpaired t-test. A P < 0.05 was deemed statistically significant.
RESULTS: There was a substantial rise in the mean level of SUA in cases on the 0, 3rd, and 7th days were 8.503 + 2.976 mg/dl, 5.472 + 2.683 mg/dl, and 4.992 + 1.707 mg/dl day, respectively, which were higher than controls group (3.976 + 0.947 mg/dl). Comparison between control and AMI SUA on 0 and 3rd days was found to be more significant than the 7th day. There was a substantial rise in blood uric acid levels in cases when compared to healthy controls (P < 0.005).
CONCLUSION: Thus, the study shows that blood uric acid levels play a significant role in the diagnosis and therapy of AMI. |
| first_indexed | 2024-04-10T09:56:14Z |
| format | Article |
| id | doaj.art-163f3dc982294be49f3db0f826a59719 |
| institution | Directory Open Access Journal |
| issn | 2542-6214 2542-6222 |
| language | English |
| last_indexed | 2024-04-10T09:56:14Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Health Sciences and Biomedical Research KLEU |
| spelling | doaj.art-163f3dc982294be49f3db0f826a597192023-02-16T12:20:02ZengWolters Kluwer Medknow PublicationsIndian Journal of Health Sciences and Biomedical Research KLEU2542-62142542-62222023-01-0116111111410.4103/kleuhsj.kleuhsj_171_22Estimation of serum uric acid in patients of acute myocardial infarctionDevendra Nath MishraRajesh Kumar SinghHari PrasadAnuj DwivediBACKGROUND: Acute myocardial infarction (AMI), often known as a heart attack, is a medical emergency that is the top cause of mortality for both men and women worldwide. Recent evidence suggests that it is caused by the sudden blockage of a coronary artery by a blood clot, also known as coronary thrombosis. Due to the regional impending of blood supply, heart muscles become damaged. Uric acid has been shown in large cohort studies to be an important independent risk factor for cardiovascular mortality. As serum uric acid (SUA) is an early predictor hence study will help to devise a better remedy for AMI. AIM: This study aims to study the levels of SUA in patients with AMI as compared to the control. OBJECTIVE: The primary goal of this study is to examine SUA levels in patients with AMI and to correlate uric acid levels with associated mortality in AMI. The secondary goal is to predict AMI early diagnosis, better management and treatment, and prognosis. METHODS: The current study was conducted at the department of biochemistry and the central investigation laboratory at our institute, in partnership with the department of medicine, intense cardiac care units, medical intensive care units, and emergency and private hospitals. A total of 100 patients were investigated. There were 50 instances of AMI and 50 age-matched healthy controls. The Microlab 300 analyzers (semi-autoanalyzer) were used to assess SUA concentrations, and the comparisons between the two groups were examined using an unpaired t-test. A P < 0.05 was deemed statistically significant. RESULTS: There was a substantial rise in the mean level of SUA in cases on the 0, 3rd, and 7th days were 8.503 + 2.976 mg/dl, 5.472 + 2.683 mg/dl, and 4.992 + 1.707 mg/dl day, respectively, which were higher than controls group (3.976 + 0.947 mg/dl). Comparison between control and AMI SUA on 0 and 3rd days was found to be more significant than the 7th day. There was a substantial rise in blood uric acid levels in cases when compared to healthy controls (P < 0.005). CONCLUSION: Thus, the study shows that blood uric acid levels play a significant role in the diagnosis and therapy of AMI.http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2023;volume=16;issue=1;spage=111;epage=114;aulast=Mishraacute myocardial infarctionheart attackserum uric acid |
| spellingShingle | Devendra Nath Mishra Rajesh Kumar Singh Hari Prasad Anuj Dwivedi Estimation of serum uric acid in patients of acute myocardial infarction Indian Journal of Health Sciences and Biomedical Research KLEU acute myocardial infarction heart attack serum uric acid |
| title | Estimation of serum uric acid in patients of acute myocardial infarction |
| title_full | Estimation of serum uric acid in patients of acute myocardial infarction |
| title_fullStr | Estimation of serum uric acid in patients of acute myocardial infarction |
| title_full_unstemmed | Estimation of serum uric acid in patients of acute myocardial infarction |
| title_short | Estimation of serum uric acid in patients of acute myocardial infarction |
| title_sort | estimation of serum uric acid in patients of acute myocardial infarction |
| topic | acute myocardial infarction heart attack serum uric acid |
| url | http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2023;volume=16;issue=1;spage=111;epage=114;aulast=Mishra |
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