Clinical response to probiotic supplementation in patients with osteoarthritis
Background: Amelioration of pain and symptoms in osteoarthritis (OA) is a challenge owing to potential side effects of current medications and need of its long-term use. Probiotic supplementation has a promising profile on immunomodulation, reduction in inflammation, and beneficial effect on bone me...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2023-05-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/52166 |
| _version_ | 1827956032377192448 |
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| author | Krishna Sai Srivani Pulugurtha Venkata Anil Chandra Dronamraju Himavathy Kodandarao Gara Dharma Rao Vanamali |
| author_facet | Krishna Sai Srivani Pulugurtha Venkata Anil Chandra Dronamraju Himavathy Kodandarao Gara Dharma Rao Vanamali |
| author_sort | Krishna Sai Srivani Pulugurtha |
| collection | DOAJ |
| description | Background: Amelioration of pain and symptoms in osteoarthritis (OA) is a challenge owing to potential side effects of current medications and need of its long-term use. Probiotic supplementation has a promising profile on immunomodulation, reduction in inflammation, and beneficial effect on bone metabolism.
Aims and Objectives: The study aimed to determine the effect of probiotic supplementation in OA patients.
Materials and Methods: This hospital-based intervention was conducted among 58 patients with OA-knee for a period from June 2021 to August 2021, who were randomized into control and interventional groups and who were asked to consume conventional curd and probiotic curd, respectively. However, data analysis was limited to 25 and 27 participants in the control and interventional groups, respectively, after 8 weeks, owing to dropouts. Anthropometric measurements, Western Ontario and McMaster Universities OA Index (WOMAC), visual analog scale (VAS) scores, and high-sensitivity CRP (hs-CRP levels) were obtained at the beginning and end of the study period.
Results: After 8 weeks of intervention, there was a significant improvement in WOMAC and VAS scores in the interventional group as compared to the control groups. Furthermore, hs-CRP levels were significantly reduced in interventional group than the control group.
Conclusion: Probiotics supplementation has the potential as a disease-modifying therapeutic agent in clinical management of OA knee patients, by improving WOMAC scores and VAS scores and reducing hs-CRP levels. |
| first_indexed | 2024-04-09T14:58:13Z |
| format | Article |
| id | doaj.art-163f5d68ff0147289a0ac8fd0aac42bd |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-09T14:58:13Z |
| publishDate | 2023-05-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-163f5d68ff0147289a0ac8fd0aac42bd2023-05-02T00:09:15ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-05-01145154160https://doi.org/10.3126/ajms.v14i5.52166Clinical response to probiotic supplementation in patients with osteoarthritisKrishna Sai Srivani Pulugurtha 0https://orcid.org/0009-0005-0837-3172Venkata Anil Chandra Dronamraju 1https://orcid.org/0000-0001-9133-7714Himavathy Kodandarao Gara 2https://orcid.org/0000-0002-1152-5916Dharma Rao Vanamali 3https://orcid.org/0000-0003-2500-8263Undergraduate Student, Gayatri Vidya Parishad Institute of Healthcare and Medical Technology, Visakhapatnam, Andhra Pradesh, IndiaAssistant Professor, Department of General Surgery, Gayatri Vidya Parishad Institute of Healthcare and Medical Technology, Visakhapatnam, Andhra Pradesh, India Associate Professor, Department of Physiology, Gayatri Vidya Parishad Institute of Healthcare and Medical Technology, Visakhapatnam, Andhra Pradesh, India Professor and Additional Medical Superintendent, Department of General Medicine, Gayatri Vidya Parishad Institute of Healthcare and Medical Technology, Visakhapatnam, Andhra Pradesh, India Background: Amelioration of pain and symptoms in osteoarthritis (OA) is a challenge owing to potential side effects of current medications and need of its long-term use. Probiotic supplementation has a promising profile on immunomodulation, reduction in inflammation, and beneficial effect on bone metabolism. Aims and Objectives: The study aimed to determine the effect of probiotic supplementation in OA patients. Materials and Methods: This hospital-based intervention was conducted among 58 patients with OA-knee for a period from June 2021 to August 2021, who were randomized into control and interventional groups and who were asked to consume conventional curd and probiotic curd, respectively. However, data analysis was limited to 25 and 27 participants in the control and interventional groups, respectively, after 8 weeks, owing to dropouts. Anthropometric measurements, Western Ontario and McMaster Universities OA Index (WOMAC), visual analog scale (VAS) scores, and high-sensitivity CRP (hs-CRP levels) were obtained at the beginning and end of the study period. Results: After 8 weeks of intervention, there was a significant improvement in WOMAC and VAS scores in the interventional group as compared to the control groups. Furthermore, hs-CRP levels were significantly reduced in interventional group than the control group. Conclusion: Probiotics supplementation has the potential as a disease-modifying therapeutic agent in clinical management of OA knee patients, by improving WOMAC scores and VAS scores and reducing hs-CRP levels.https://www.nepjol.info/index.php/AJMS/article/view/52166osteoarthritis knee; inflammation; probiotics; womac scores; visual analogue scale scores; hs-crp levels |
| spellingShingle | Krishna Sai Srivani Pulugurtha Venkata Anil Chandra Dronamraju Himavathy Kodandarao Gara Dharma Rao Vanamali Clinical response to probiotic supplementation in patients with osteoarthritis Asian Journal of Medical Sciences osteoarthritis knee; inflammation; probiotics; womac scores; visual analogue scale scores; hs-crp levels |
| title | Clinical response to probiotic supplementation in patients with osteoarthritis |
| title_full | Clinical response to probiotic supplementation in patients with osteoarthritis |
| title_fullStr | Clinical response to probiotic supplementation in patients with osteoarthritis |
| title_full_unstemmed | Clinical response to probiotic supplementation in patients with osteoarthritis |
| title_short | Clinical response to probiotic supplementation in patients with osteoarthritis |
| title_sort | clinical response to probiotic supplementation in patients with osteoarthritis |
| topic | osteoarthritis knee; inflammation; probiotics; womac scores; visual analogue scale scores; hs-crp levels |
| url | https://www.nepjol.info/index.php/AJMS/article/view/52166 |
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