Summer and spring elbow rashes is a variant of polymorphous light eruption: confirmation by photoprovocation and histopathology in a series of five cases
BackgroundSummer and spring eruptions on the elbows are a variant of polymorphous light eruption described on clinical and histopathological grounds; however, to our knowledge, they have not been confirmed by photobiological studies.ObjectiveBased on photobiological studies, this study aimed to demo...
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| Format: | Article |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1260514/full |
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| author | María Victoria de Gálvez Rosa Maria Castillo-Muñoz Norberto López-Navarro Patricio López-Jiménez Enrique Navarrete-de Gálvez Ricardo Bosch-García Ricardo Bosch-García Enrique Herrera-Acosta Enrique Herrera-Acosta José Aguilera |
| author_facet | María Victoria de Gálvez Rosa Maria Castillo-Muñoz Norberto López-Navarro Patricio López-Jiménez Enrique Navarrete-de Gálvez Ricardo Bosch-García Ricardo Bosch-García Enrique Herrera-Acosta Enrique Herrera-Acosta José Aguilera |
| author_sort | María Victoria de Gálvez |
| collection | DOAJ |
| description | BackgroundSummer and spring eruptions on the elbows are a variant of polymorphous light eruption described on clinical and histopathological grounds; however, to our knowledge, they have not been confirmed by photobiological studies.ObjectiveBased on photobiological studies, this study aimed to demonstrate the involvement of ultraviolet-A (UVA) radiation in this variant of polymorphous light eruption occurring exclusively on the elbows.MethodsA series of five patients with polymorphous light eruption lesions on the elbows were included in our study. All patients underwent phototesting and photoprovocation of the skin lesions after exposure to a UVA light source [Philips UVA HPA lamp (400 W)]. All patients underwent punch biopsy and histopathological and immunohistochemical studies with anti-CD123.ResultsIn all the cases, UVA irradiation caused the appearance of skin lesions on the elbows with characteristic polymorphous light eruption. Histological data showed edema in the superficial dermis and a perivascular lymphocytic infiltrate compatible with polymorphous light eruption. Immunohistochemical staining for CD1-23 showed negative results.ConclusionsFor the first time, photobiological photoprovocation studies demonstrated that repeated exposure to UVA radiation leads to the generation of skin lesions on the elbows, which are clinically and histologically consistent with summer and spring eruptions, confirming that elbow rash is a variant of polymorphous light eruption. |
| first_indexed | 2024-03-11T17:23:13Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-11T17:23:13Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj.art-163fc555927d4832a5cf6cbb4a98d9092023-10-19T07:46:47ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-10-011010.3389/fmed.2023.12605141260514Summer and spring elbow rashes is a variant of polymorphous light eruption: confirmation by photoprovocation and histopathology in a series of five casesMaría Victoria de Gálvez0Rosa Maria Castillo-Muñoz1Norberto López-Navarro2Patricio López-Jiménez3Enrique Navarrete-de Gálvez4Ricardo Bosch-García5Ricardo Bosch-García6Enrique Herrera-Acosta7Enrique Herrera-Acosta8José Aguilera9Photobiological Dermatology Laboratory, Medical Research Center, Department of Dermatology and Medicine, Faculty of Medicine, University of Málaga, Málaga, SpainDermatology Service, Hospital Clínico Universitario Virgen de la Victoria, Málaga, SpainDermatology Service, Hospital Clínico Universitario Virgen de la Victoria, Málaga, SpainDermatology Service, Hospital de Poniente, Almería, SpainProject Engineering Area, Department of Graphic Expression Design and Projects, School of Engineering, University of Málaga, Málaga, SpainPhotobiological Dermatology Laboratory, Medical Research Center, Department of Dermatology and Medicine, Faculty of Medicine, University of Málaga, Málaga, SpainDermatology Service, Hospital Clínico Universitario Virgen de la Victoria, Málaga, SpainPhotobiological Dermatology Laboratory, Medical Research Center, Department of Dermatology and Medicine, Faculty of Medicine, University of Málaga, Málaga, SpainDermatology Service, Hospital Clínico Universitario Virgen de la Victoria, Málaga, SpainPhotobiological Dermatology Laboratory, Medical Research Center, Department of Dermatology and Medicine, Faculty of Medicine, University of Málaga, Málaga, SpainBackgroundSummer and spring eruptions on the elbows are a variant of polymorphous light eruption described on clinical and histopathological grounds; however, to our knowledge, they have not been confirmed by photobiological studies.ObjectiveBased on photobiological studies, this study aimed to demonstrate the involvement of ultraviolet-A (UVA) radiation in this variant of polymorphous light eruption occurring exclusively on the elbows.MethodsA series of five patients with polymorphous light eruption lesions on the elbows were included in our study. All patients underwent phototesting and photoprovocation of the skin lesions after exposure to a UVA light source [Philips UVA HPA lamp (400 W)]. All patients underwent punch biopsy and histopathological and immunohistochemical studies with anti-CD123.ResultsIn all the cases, UVA irradiation caused the appearance of skin lesions on the elbows with characteristic polymorphous light eruption. Histological data showed edema in the superficial dermis and a perivascular lymphocytic infiltrate compatible with polymorphous light eruption. Immunohistochemical staining for CD1-23 showed negative results.ConclusionsFor the first time, photobiological photoprovocation studies demonstrated that repeated exposure to UVA radiation leads to the generation of skin lesions on the elbows, which are clinically and histologically consistent with summer and spring eruptions, confirming that elbow rash is a variant of polymorphous light eruption.https://www.frontiersin.org/articles/10.3389/fmed.2023.1260514/fullpolymorphous light eruptionspring and summer eruptionultraviolet Aphototestphotoprovocationelbow |
| spellingShingle | María Victoria de Gálvez Rosa Maria Castillo-Muñoz Norberto López-Navarro Patricio López-Jiménez Enrique Navarrete-de Gálvez Ricardo Bosch-García Ricardo Bosch-García Enrique Herrera-Acosta Enrique Herrera-Acosta José Aguilera Summer and spring elbow rashes is a variant of polymorphous light eruption: confirmation by photoprovocation and histopathology in a series of five cases Frontiers in Medicine polymorphous light eruption spring and summer eruption ultraviolet A phototest photoprovocation elbow |
| title | Summer and spring elbow rashes is a variant of polymorphous light eruption: confirmation by photoprovocation and histopathology in a series of five cases |
| title_full | Summer and spring elbow rashes is a variant of polymorphous light eruption: confirmation by photoprovocation and histopathology in a series of five cases |
| title_fullStr | Summer and spring elbow rashes is a variant of polymorphous light eruption: confirmation by photoprovocation and histopathology in a series of five cases |
| title_full_unstemmed | Summer and spring elbow rashes is a variant of polymorphous light eruption: confirmation by photoprovocation and histopathology in a series of five cases |
| title_short | Summer and spring elbow rashes is a variant of polymorphous light eruption: confirmation by photoprovocation and histopathology in a series of five cases |
| title_sort | summer and spring elbow rashes is a variant of polymorphous light eruption confirmation by photoprovocation and histopathology in a series of five cases |
| topic | polymorphous light eruption spring and summer eruption ultraviolet A phototest photoprovocation elbow |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1260514/full |
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