Multifunctional biomaterial platforms for blocking the fibrosis process and promoting cellular restoring effects in myocardial fibrosis therapy
Myocardial fibrosis is the result of abnormal healing after acute and chronic myocardial damage and is a direct cause of heart failure and cardiac insufficiency. The clinical approach is to preserve cardiac function and inhibit fibrosis through surgery aimed at dredging blood vessels. However, this...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.988683/full |
| _version_ | 1798033824909623296 |
|---|---|
| author | Tian Yue Tian Yue Shiqiang Xiong Dezhi Zheng Yi Wang Pan Long Jiali Yang Jiali Yang Dunzhu Danzeng Han Gao Xudong Wen Xin Li Jun Hou Jun Hou |
| author_facet | Tian Yue Tian Yue Shiqiang Xiong Dezhi Zheng Yi Wang Pan Long Jiali Yang Jiali Yang Dunzhu Danzeng Han Gao Xudong Wen Xin Li Jun Hou Jun Hou |
| author_sort | Tian Yue |
| collection | DOAJ |
| description | Myocardial fibrosis is the result of abnormal healing after acute and chronic myocardial damage and is a direct cause of heart failure and cardiac insufficiency. The clinical approach is to preserve cardiac function and inhibit fibrosis through surgery aimed at dredging blood vessels. However, this strategy does not adequately address the deterioration of fibrosis and cardiac function recovery. Therefore, numerous biomaterial platforms have been developed to address the above issues. In this review, we summarize the existing biomaterial delivery and restoring platforms, In addition, we also clarify the therapeutic strategies based on biomaterial platforms, including general strategies to block the fibrosis process and new strategies to promote cellular restoring effects. The development of structures with the ability to block further fibrosis progression as well as to promote cardiomyocytes viability should be the main research interests in myocardial fibrosis, and the reestablishment of structures necessary for normal cardiac function is central to the treatment of myocardial fibrosis. Finally, the future application of biomaterials for myocardial fibrosis is also highlighted. |
| first_indexed | 2024-04-11T20:35:48Z |
| format | Article |
| id | doaj.art-164088c562ef47b4ac5898cef5744bda |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-11T20:35:48Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-164088c562ef47b4ac5898cef5744bda2022-12-22T04:04:22ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-09-011010.3389/fbioe.2022.988683988683Multifunctional biomaterial platforms for blocking the fibrosis process and promoting cellular restoring effects in myocardial fibrosis therapyTian Yue0Tian Yue1Shiqiang Xiong2Dezhi Zheng3Yi Wang4Pan Long5Jiali Yang6Jiali Yang7Dunzhu Danzeng8Han Gao9Xudong Wen10Xin Li11Jun Hou12Jun Hou13Department of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, The Third People’s Hospital of Chengdu, Cardiovascular Disease Research Institute of Chengdu, Chengdu, ChinaSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, ChinaDepartment of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, The Third People’s Hospital of Chengdu, Cardiovascular Disease Research Institute of Chengdu, Chengdu, ChinaDepartment of Cardiovascular Surgery, The 960th Hospital of the PLA Joint Logistic Support Force, Jinan, ChinaSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, ChinaSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, ChinaDepartment of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, The Third People’s Hospital of Chengdu, Cardiovascular Disease Research Institute of Chengdu, Chengdu, ChinaSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, ChinaDepartment of Basic Medicine, Medical College, Tibet University, Lhasa, ChinaDepartment of Basic Medicine, Medical College, Tibet University, Lhasa, ChinaDepartment of Gastroenterology and Hepatology, Chengdu First People’s Hospital, Chengdu, ChinaDepartment of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, The Third People’s Hospital of Chengdu, Cardiovascular Disease Research Institute of Chengdu, Chengdu, ChinaDepartment of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, The Third People’s Hospital of Chengdu, Cardiovascular Disease Research Institute of Chengdu, Chengdu, ChinaSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, ChinaMyocardial fibrosis is the result of abnormal healing after acute and chronic myocardial damage and is a direct cause of heart failure and cardiac insufficiency. The clinical approach is to preserve cardiac function and inhibit fibrosis through surgery aimed at dredging blood vessels. However, this strategy does not adequately address the deterioration of fibrosis and cardiac function recovery. Therefore, numerous biomaterial platforms have been developed to address the above issues. In this review, we summarize the existing biomaterial delivery and restoring platforms, In addition, we also clarify the therapeutic strategies based on biomaterial platforms, including general strategies to block the fibrosis process and new strategies to promote cellular restoring effects. The development of structures with the ability to block further fibrosis progression as well as to promote cardiomyocytes viability should be the main research interests in myocardial fibrosis, and the reestablishment of structures necessary for normal cardiac function is central to the treatment of myocardial fibrosis. Finally, the future application of biomaterials for myocardial fibrosis is also highlighted.https://www.frontiersin.org/articles/10.3389/fbioe.2022.988683/fullmyocardial fibrosisextracellular matrixhydrogelnanoparticlesbiomaterialsmultifunctional |
| spellingShingle | Tian Yue Tian Yue Shiqiang Xiong Dezhi Zheng Yi Wang Pan Long Jiali Yang Jiali Yang Dunzhu Danzeng Han Gao Xudong Wen Xin Li Jun Hou Jun Hou Multifunctional biomaterial platforms for blocking the fibrosis process and promoting cellular restoring effects in myocardial fibrosis therapy Frontiers in Bioengineering and Biotechnology myocardial fibrosis extracellular matrix hydrogel nanoparticles biomaterials multifunctional |
| title | Multifunctional biomaterial platforms for blocking the fibrosis process and promoting cellular restoring effects in myocardial fibrosis therapy |
| title_full | Multifunctional biomaterial platforms for blocking the fibrosis process and promoting cellular restoring effects in myocardial fibrosis therapy |
| title_fullStr | Multifunctional biomaterial platforms for blocking the fibrosis process and promoting cellular restoring effects in myocardial fibrosis therapy |
| title_full_unstemmed | Multifunctional biomaterial platforms for blocking the fibrosis process and promoting cellular restoring effects in myocardial fibrosis therapy |
| title_short | Multifunctional biomaterial platforms for blocking the fibrosis process and promoting cellular restoring effects in myocardial fibrosis therapy |
| title_sort | multifunctional biomaterial platforms for blocking the fibrosis process and promoting cellular restoring effects in myocardial fibrosis therapy |
| topic | myocardial fibrosis extracellular matrix hydrogel nanoparticles biomaterials multifunctional |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.988683/full |
| work_keys_str_mv | AT tianyue multifunctionalbiomaterialplatformsforblockingthefibrosisprocessandpromotingcellularrestoringeffectsinmyocardialfibrosistherapy AT tianyue multifunctionalbiomaterialplatformsforblockingthefibrosisprocessandpromotingcellularrestoringeffectsinmyocardialfibrosistherapy AT shiqiangxiong multifunctionalbiomaterialplatformsforblockingthefibrosisprocessandpromotingcellularrestoringeffectsinmyocardialfibrosistherapy AT dezhizheng multifunctionalbiomaterialplatformsforblockingthefibrosisprocessandpromotingcellularrestoringeffectsinmyocardialfibrosistherapy AT yiwang multifunctionalbiomaterialplatformsforblockingthefibrosisprocessandpromotingcellularrestoringeffectsinmyocardialfibrosistherapy AT panlong multifunctionalbiomaterialplatformsforblockingthefibrosisprocessandpromotingcellularrestoringeffectsinmyocardialfibrosistherapy AT jialiyang multifunctionalbiomaterialplatformsforblockingthefibrosisprocessandpromotingcellularrestoringeffectsinmyocardialfibrosistherapy AT jialiyang multifunctionalbiomaterialplatformsforblockingthefibrosisprocessandpromotingcellularrestoringeffectsinmyocardialfibrosistherapy AT dunzhudanzeng multifunctionalbiomaterialplatformsforblockingthefibrosisprocessandpromotingcellularrestoringeffectsinmyocardialfibrosistherapy AT hangao multifunctionalbiomaterialplatformsforblockingthefibrosisprocessandpromotingcellularrestoringeffectsinmyocardialfibrosistherapy AT xudongwen multifunctionalbiomaterialplatformsforblockingthefibrosisprocessandpromotingcellularrestoringeffectsinmyocardialfibrosistherapy AT xinli multifunctionalbiomaterialplatformsforblockingthefibrosisprocessandpromotingcellularrestoringeffectsinmyocardialfibrosistherapy AT junhou multifunctionalbiomaterialplatformsforblockingthefibrosisprocessandpromotingcellularrestoringeffectsinmyocardialfibrosistherapy AT junhou multifunctionalbiomaterialplatformsforblockingthefibrosisprocessandpromotingcellularrestoringeffectsinmyocardialfibrosistherapy |