The Acute Toxicity and Hematological Characterization of the Effects of Tentacle-Only Extract from the Jellyfish Cyanea capillata
To investigate the hematologic changes and the activities of jellyfish venoms other than hemolytic and cardiovascular toxicities, the acute toxicity of tentacle-only extract (TOE) from the jellyfish Cyanea capillata was observed in mice, and hematological indexes were examined in rats. The median le...
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| Format: | Article |
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MDPI AG
2011-03-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/9/4/526/ |
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| author | Liming Zhang Jie Zhao Fei Nie Qianqian Wang Guoyan Liu Xuting Ye Qian He Liang Xiao Sihua Liu |
| author_facet | Liming Zhang Jie Zhao Fei Nie Qianqian Wang Guoyan Liu Xuting Ye Qian He Liang Xiao Sihua Liu |
| author_sort | Liming Zhang |
| collection | DOAJ |
| description | To investigate the hematologic changes and the activities of jellyfish venoms other than hemolytic and cardiovascular toxicities, the acute toxicity of tentacle-only extract (TOE) from the jellyfish Cyanea capillata was observed in mice, and hematological indexes were examined in rats. The median lethal dose (LD50) of TOE was 4.25 mg/kg, and the acute toxicity involved both heart- and nervous system-related symptoms. Arterial blood gas indexes, including pH, PCO2, HCO3−, HCO3std, TCO2, BEecf and BE (B), decreased significantly. PO2 showed a slight increase, while SO2c (%) had no change at any time. Na+ and Ca2+ decreased, but K+ increased. Biochemical indexes, including LDH, CK, CK-MB, ALT, AST and sCr, significantly increased. Other biochemical indexes, including BUN and hemodiastase, remained normal. Lactic acid significantly increased, while glucose, Hct% and THbc showed slight temporary increases and then returned to normal. These results on the acute toxicity and hematological changes should improve our understanding of the in vivo pathophysiological effects of TOE from C. capillata and indicate that it may also have neurotoxicity, liver toxicity and muscular toxicity in addition to hemolytic and cardiovascular toxicities, but no kidney or pancreatic toxicity. |
| first_indexed | 2024-04-14T06:18:27Z |
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| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T06:18:27Z |
| publishDate | 2011-03-01 |
| publisher | MDPI AG |
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| series | Marine Drugs |
| spelling | doaj.art-1640bb4dc4fa4d0595ecbbe0015e05212022-12-22T02:08:06ZengMDPI AGMarine Drugs1660-33972011-03-019452653410.3390/md9040526The Acute Toxicity and Hematological Characterization of the Effects of Tentacle-Only Extract from the Jellyfish Cyanea capillataLiming ZhangJie ZhaoFei NieQianqian WangGuoyan LiuXuting YeQian HeLiang XiaoSihua LiuTo investigate the hematologic changes and the activities of jellyfish venoms other than hemolytic and cardiovascular toxicities, the acute toxicity of tentacle-only extract (TOE) from the jellyfish Cyanea capillata was observed in mice, and hematological indexes were examined in rats. The median lethal dose (LD50) of TOE was 4.25 mg/kg, and the acute toxicity involved both heart- and nervous system-related symptoms. Arterial blood gas indexes, including pH, PCO2, HCO3−, HCO3std, TCO2, BEecf and BE (B), decreased significantly. PO2 showed a slight increase, while SO2c (%) had no change at any time. Na+ and Ca2+ decreased, but K+ increased. Biochemical indexes, including LDH, CK, CK-MB, ALT, AST and sCr, significantly increased. Other biochemical indexes, including BUN and hemodiastase, remained normal. Lactic acid significantly increased, while glucose, Hct% and THbc showed slight temporary increases and then returned to normal. These results on the acute toxicity and hematological changes should improve our understanding of the in vivo pathophysiological effects of TOE from C. capillata and indicate that it may also have neurotoxicity, liver toxicity and muscular toxicity in addition to hemolytic and cardiovascular toxicities, but no kidney or pancreatic toxicity.http://www.mdpi.com/1660-3397/9/4/526/jellyfishCyanea capillatatentacle-only extractLD50toxic symptomhematological |
| spellingShingle | Liming Zhang Jie Zhao Fei Nie Qianqian Wang Guoyan Liu Xuting Ye Qian He Liang Xiao Sihua Liu The Acute Toxicity and Hematological Characterization of the Effects of Tentacle-Only Extract from the Jellyfish Cyanea capillata Marine Drugs jellyfish Cyanea capillata tentacle-only extract LD50 toxic symptom hematological |
| title | The Acute Toxicity and Hematological Characterization of the Effects of Tentacle-Only Extract from the Jellyfish Cyanea capillata |
| title_full | The Acute Toxicity and Hematological Characterization of the Effects of Tentacle-Only Extract from the Jellyfish Cyanea capillata |
| title_fullStr | The Acute Toxicity and Hematological Characterization of the Effects of Tentacle-Only Extract from the Jellyfish Cyanea capillata |
| title_full_unstemmed | The Acute Toxicity and Hematological Characterization of the Effects of Tentacle-Only Extract from the Jellyfish Cyanea capillata |
| title_short | The Acute Toxicity and Hematological Characterization of the Effects of Tentacle-Only Extract from the Jellyfish Cyanea capillata |
| title_sort | acute toxicity and hematological characterization of the effects of tentacle only extract from the jellyfish cyanea capillata |
| topic | jellyfish Cyanea capillata tentacle-only extract LD50 toxic symptom hematological |
| url | http://www.mdpi.com/1660-3397/9/4/526/ |
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