Overweight as a Prognostic Factor for Triple-Negative Breast Cancers in Chinese Women.
Obesity is associated with poorer outcomes in patients with hormone receptor-positive breast cancers, but this association is not well established for women with triple-negative breast cancers (TNBC). Here, we investigated the prognostic effects of body mass index (BMI) on clinical outcomes in patie...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4479880?pdf=render |
| _version_ | 1811331754276945920 |
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| author | Shuang Hao Yin Liu Ke-Da Yu Sheng Chen Wen-Tao Yang Zhi-Min Shao |
| author_facet | Shuang Hao Yin Liu Ke-Da Yu Sheng Chen Wen-Tao Yang Zhi-Min Shao |
| author_sort | Shuang Hao |
| collection | DOAJ |
| description | Obesity is associated with poorer outcomes in patients with hormone receptor-positive breast cancers, but this association is not well established for women with triple-negative breast cancers (TNBC). Here, we investigated the prognostic effects of body mass index (BMI) on clinical outcomes in patients with TNBC.We identified 1106 patients with TNBC who met the inclusion criteria and were treated between January 2002 and June 2012. Clinical and biological features were collected to evaluate the relation between BMI and breast cancer-specific survival (BCSS) and overall survival (OS) after controlling for other clinically significant variables.Of 1106 patients, 656 (59.3%) were normal weight (BMI ≤24) and 450 patients (40.7%) were overweight(BMI>24). Median follow-up time was 44.8 months. Breast cancer specific death was observed in 140 patients. After adjusting for clinicopathologic risk factors, overweight was associated with OS (hazard ratio [HR]: 1.46, 95% confidence interval [CI]: 1.04-2.06, P =0.028) but not BCSS (HR: 1.34, 95% CI: 0.90-2.01, P =0.15)in all the patients with TNBC. When stratified with menopausal status, overweight was associated with BCSS and OS (HR: 2.27, 95% CI: 1.11-4.63, P = 0.024 and HR: 2.16, 95% CI: 1.21-3.87, P = 0.010, respectively) in premenopausal women. BMI was not associated with BCSS or OS in postmenopausal women.Overweight is an independent prognostic factor of OS in all women with TNBC, and menopause status may be a mitigating factor. Among premenopausal women, overweight women are at a greater risk of poor prognosis than normal weight women. If validated, these findings should be considered in developing preventive programs. |
| first_indexed | 2024-04-13T16:25:27Z |
| format | Article |
| id | doaj.art-1640cba0e3454411be31a7e7ba4e3e24 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T16:25:27Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1640cba0e3454411be31a7e7ba4e3e242022-12-22T02:39:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e012974110.1371/journal.pone.0129741Overweight as a Prognostic Factor for Triple-Negative Breast Cancers in Chinese Women.Shuang HaoYin LiuKe-Da YuSheng ChenWen-Tao YangZhi-Min ShaoObesity is associated with poorer outcomes in patients with hormone receptor-positive breast cancers, but this association is not well established for women with triple-negative breast cancers (TNBC). Here, we investigated the prognostic effects of body mass index (BMI) on clinical outcomes in patients with TNBC.We identified 1106 patients with TNBC who met the inclusion criteria and were treated between January 2002 and June 2012. Clinical and biological features were collected to evaluate the relation between BMI and breast cancer-specific survival (BCSS) and overall survival (OS) after controlling for other clinically significant variables.Of 1106 patients, 656 (59.3%) were normal weight (BMI ≤24) and 450 patients (40.7%) were overweight(BMI>24). Median follow-up time was 44.8 months. Breast cancer specific death was observed in 140 patients. After adjusting for clinicopathologic risk factors, overweight was associated with OS (hazard ratio [HR]: 1.46, 95% confidence interval [CI]: 1.04-2.06, P =0.028) but not BCSS (HR: 1.34, 95% CI: 0.90-2.01, P =0.15)in all the patients with TNBC. When stratified with menopausal status, overweight was associated with BCSS and OS (HR: 2.27, 95% CI: 1.11-4.63, P = 0.024 and HR: 2.16, 95% CI: 1.21-3.87, P = 0.010, respectively) in premenopausal women. BMI was not associated with BCSS or OS in postmenopausal women.Overweight is an independent prognostic factor of OS in all women with TNBC, and menopause status may be a mitigating factor. Among premenopausal women, overweight women are at a greater risk of poor prognosis than normal weight women. If validated, these findings should be considered in developing preventive programs.http://europepmc.org/articles/PMC4479880?pdf=render |
| spellingShingle | Shuang Hao Yin Liu Ke-Da Yu Sheng Chen Wen-Tao Yang Zhi-Min Shao Overweight as a Prognostic Factor for Triple-Negative Breast Cancers in Chinese Women. PLoS ONE |
| title | Overweight as a Prognostic Factor for Triple-Negative Breast Cancers in Chinese Women. |
| title_full | Overweight as a Prognostic Factor for Triple-Negative Breast Cancers in Chinese Women. |
| title_fullStr | Overweight as a Prognostic Factor for Triple-Negative Breast Cancers in Chinese Women. |
| title_full_unstemmed | Overweight as a Prognostic Factor for Triple-Negative Breast Cancers in Chinese Women. |
| title_short | Overweight as a Prognostic Factor for Triple-Negative Breast Cancers in Chinese Women. |
| title_sort | overweight as a prognostic factor for triple negative breast cancers in chinese women |
| url | http://europepmc.org/articles/PMC4479880?pdf=render |
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