Chinese medicinal herbs as potential prodrugs for obesity
Obesity is a leading worldwide health threat with ever-growing prevalence, it promotes the incidence of various diseases, particularly cardiovascular disease, metabolic syndrome, diabetes, hypertension, and certain cancers. Traditional Chinese Medicine (TCM) has been used to control body weight and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1016004/full |
| _version_ | 1811205088208748544 |
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| author | Siu Kan Law Siu Kan Law Yanping Wang Xinchen Lu Dawn Ching Tung Au Wesley Yeuk Lung Chow Albert Wing Nang Leung Chuanshan Xu |
| author_facet | Siu Kan Law Siu Kan Law Yanping Wang Xinchen Lu Dawn Ching Tung Au Wesley Yeuk Lung Chow Albert Wing Nang Leung Chuanshan Xu |
| author_sort | Siu Kan Law |
| collection | DOAJ |
| description | Obesity is a leading worldwide health threat with ever-growing prevalence, it promotes the incidence of various diseases, particularly cardiovascular disease, metabolic syndrome, diabetes, hypertension, and certain cancers. Traditional Chinese Medicine (TCM) has been used to control body weight and treat obesity for thousands of years, Chinese medicinal herbs provide a rich natural source of effective agents against obesity. However, some problems such as complex active ingredients, poor quality control, and unclear therapeutic mechanisms still need to be investigated and resolved. Prodrugs provide a path forward to overcome TCM deficiencies such as absorption, distribution, metabolism, excretion (ADME) properties, and toxicity. This article aimed to review the possible prodrugs from various medicinal plants that demonstrate beneficial effects on obesity and seek to offer insights on prodrug design as well as a solution to the global obesity issues. |
| first_indexed | 2024-04-12T03:24:43Z |
| format | Article |
| id | doaj.art-16427ba0dc8b4e86afca8c5c00a355bf |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T03:24:43Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-16427ba0dc8b4e86afca8c5c00a355bf2022-12-22T03:49:44ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-10-011310.3389/fphar.2022.10160041016004Chinese medicinal herbs as potential prodrugs for obesitySiu Kan Law0Siu Kan Law1Yanping Wang2Xinchen Lu3Dawn Ching Tung Au4Wesley Yeuk Lung Chow5Albert Wing Nang Leung6Chuanshan Xu7Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaFaculty of Science and Technology, The Technological and Higher Education Institute of Hong Kong, Hong Kong, Hong Kong SAR, ChinaSchool of Nursing and Health Studies, Hong Kong Metropolitan University, Hong Kong, Hong Kong SAR, ChinaFaculty of Science and Technology, The Technological and Higher Education Institute of Hong Kong, Hong Kong, Hong Kong SAR, ChinaFaculty of Science and Technology, The Technological and Higher Education Institute of Hong Kong, Hong Kong, Hong Kong SAR, ChinaFaculty of Science and Technology, The Technological and Higher Education Institute of Hong Kong, Hong Kong, Hong Kong SAR, ChinaSchool of Graduate Studies, Lingnan University, Tuen Mun, Hong Kong SAR, ChinaKey Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaObesity is a leading worldwide health threat with ever-growing prevalence, it promotes the incidence of various diseases, particularly cardiovascular disease, metabolic syndrome, diabetes, hypertension, and certain cancers. Traditional Chinese Medicine (TCM) has been used to control body weight and treat obesity for thousands of years, Chinese medicinal herbs provide a rich natural source of effective agents against obesity. However, some problems such as complex active ingredients, poor quality control, and unclear therapeutic mechanisms still need to be investigated and resolved. Prodrugs provide a path forward to overcome TCM deficiencies such as absorption, distribution, metabolism, excretion (ADME) properties, and toxicity. This article aimed to review the possible prodrugs from various medicinal plants that demonstrate beneficial effects on obesity and seek to offer insights on prodrug design as well as a solution to the global obesity issues.https://www.frontiersin.org/articles/10.3389/fphar.2022.1016004/fullobesityherbal medicineprodrugtraditional Chinese medicine (TCM)active ingredientmedicinal plants |
| spellingShingle | Siu Kan Law Siu Kan Law Yanping Wang Xinchen Lu Dawn Ching Tung Au Wesley Yeuk Lung Chow Albert Wing Nang Leung Chuanshan Xu Chinese medicinal herbs as potential prodrugs for obesity Frontiers in Pharmacology obesity herbal medicine prodrug traditional Chinese medicine (TCM) active ingredient medicinal plants |
| title | Chinese medicinal herbs as potential prodrugs for obesity |
| title_full | Chinese medicinal herbs as potential prodrugs for obesity |
| title_fullStr | Chinese medicinal herbs as potential prodrugs for obesity |
| title_full_unstemmed | Chinese medicinal herbs as potential prodrugs for obesity |
| title_short | Chinese medicinal herbs as potential prodrugs for obesity |
| title_sort | chinese medicinal herbs as potential prodrugs for obesity |
| topic | obesity herbal medicine prodrug traditional Chinese medicine (TCM) active ingredient medicinal plants |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1016004/full |
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