Regulation of EGFR Protein Stability by the HECT-type Ubiquitin Ligase SMURF2

Regulation of EGFR Protein Stability by the HECT-type Ubiquitin Ligase SMURF2

Epidermal growth factor receptor (EGFR) is overexpressed in a variety of epithelial tumors and is considered to be an important therapeutic target. Although gene amplification is responsible for EGFR overexpression in certain human malignancies including lung and head and neck cancers, additional mo...

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Bibliographic Details
Main Authors: Dipankar Ray, Aarif Ahsan, Abigail Helman, Guoan Chen, Ashok Hegde, Susmita Ramanand Gurjar, Lili Zhao, Hiroaki Kiyokawa, David G Beer, Theodore S Lawrence, Mukesh K Nyati
Format: Article
Language:English
Published: Elsevier 2011-07-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558611800217

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