SARS-CoV-2 Treatment: Current Therapeutic Options and the Pursuit of Tailored Therapy
One year on from the worldwide outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), medicine has made several steps towards increasing the therapeutic options against its treatment. Despite the lack of specific therapies, international societies have introduced new guidelines an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/16/7457 |
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| author | Gianmarco Marcianò Roberta Roberti Caterina Palleria Davida Mirra Vincenzo Rania Alessandro Casarella Giovambattista De Sarro Luca Gallelli |
| author_facet | Gianmarco Marcianò Roberta Roberti Caterina Palleria Davida Mirra Vincenzo Rania Alessandro Casarella Giovambattista De Sarro Luca Gallelli |
| author_sort | Gianmarco Marcianò |
| collection | DOAJ |
| description | One year on from the worldwide outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), medicine has made several steps towards increasing the therapeutic options against its treatment. Despite the lack of specific therapies, international societies have introduced new guidelines and launched several trials to test the efficacy of new protocols and drugs. Drug repurposing has been a fundamental strategy to find quick ways to fight the pathogen, even if it is new compounds that are drawing the attention of the scientific community. Tailored therapy should be considered to be a milestone in treatment in order to increase drug efficacy and to reduce drug toxicity. Therefore, both drug characteristics (i.e., pharmacokinetic, pharmacodynamic and safety) and the patient characteristics (i.e., stage of disease, comorbidity, concomitant treatments and the mutation of single nucleotides) could represent the key to achieving this objective. In the present study we performed a narrative review of the pharmacological treatment used to date in the management of coronavirus disease 2019 (COVID-19). |
| first_indexed | 2024-03-10T09:02:03Z |
| format | Article |
| id | doaj.art-1646adb100b245878681f6777f164936 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T09:02:03Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-1646adb100b245878681f6777f1649362023-11-22T06:41:53ZengMDPI AGApplied Sciences2076-34172021-08-011116745710.3390/app11167457SARS-CoV-2 Treatment: Current Therapeutic Options and the Pursuit of Tailored TherapyGianmarco Marcianò0Roberta Roberti1Caterina Palleria2Davida Mirra3Vincenzo Rania4Alessandro Casarella5Giovambattista De Sarro6Luca Gallelli7Operative Unit of Pharmacology and Pharmacovigilance, “Mater Domini” Hospital, 88100 Catanzaro, ItalyOperative Unit of Pharmacology and Pharmacovigilance, “Mater Domini” Hospital, 88100 Catanzaro, ItalyOperative Unit of Pharmacology and Pharmacovigilance, “Mater Domini” Hospital, 88100 Catanzaro, ItalyOperative Unit of Pharmacology and Pharmacovigilance, “Mater Domini” Hospital, 88100 Catanzaro, ItalyOperative Unit of Pharmacology and Pharmacovigilance, “Mater Domini” Hospital, 88100 Catanzaro, ItalyOperative Unit of Pharmacology and Pharmacovigilance, “Mater Domini” Hospital, 88100 Catanzaro, ItalyOperative Unit of Pharmacology and Pharmacovigilance, “Mater Domini” Hospital, 88100 Catanzaro, ItalyOperative Unit of Pharmacology and Pharmacovigilance, “Mater Domini” Hospital, 88100 Catanzaro, ItalyOne year on from the worldwide outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), medicine has made several steps towards increasing the therapeutic options against its treatment. Despite the lack of specific therapies, international societies have introduced new guidelines and launched several trials to test the efficacy of new protocols and drugs. Drug repurposing has been a fundamental strategy to find quick ways to fight the pathogen, even if it is new compounds that are drawing the attention of the scientific community. Tailored therapy should be considered to be a milestone in treatment in order to increase drug efficacy and to reduce drug toxicity. Therefore, both drug characteristics (i.e., pharmacokinetic, pharmacodynamic and safety) and the patient characteristics (i.e., stage of disease, comorbidity, concomitant treatments and the mutation of single nucleotides) could represent the key to achieving this objective. In the present study we performed a narrative review of the pharmacological treatment used to date in the management of coronavirus disease 2019 (COVID-19).https://www.mdpi.com/2076-3417/11/16/7457COVID-19drug treatmentindicationdrug metabolismdrug interactionadverse drug reactions |
| spellingShingle | Gianmarco Marcianò Roberta Roberti Caterina Palleria Davida Mirra Vincenzo Rania Alessandro Casarella Giovambattista De Sarro Luca Gallelli SARS-CoV-2 Treatment: Current Therapeutic Options and the Pursuit of Tailored Therapy Applied Sciences COVID-19 drug treatment indication drug metabolism drug interaction adverse drug reactions |
| title | SARS-CoV-2 Treatment: Current Therapeutic Options and the Pursuit of Tailored Therapy |
| title_full | SARS-CoV-2 Treatment: Current Therapeutic Options and the Pursuit of Tailored Therapy |
| title_fullStr | SARS-CoV-2 Treatment: Current Therapeutic Options and the Pursuit of Tailored Therapy |
| title_full_unstemmed | SARS-CoV-2 Treatment: Current Therapeutic Options and the Pursuit of Tailored Therapy |
| title_short | SARS-CoV-2 Treatment: Current Therapeutic Options and the Pursuit of Tailored Therapy |
| title_sort | sars cov 2 treatment current therapeutic options and the pursuit of tailored therapy |
| topic | COVID-19 drug treatment indication drug metabolism drug interaction adverse drug reactions |
| url | https://www.mdpi.com/2076-3417/11/16/7457 |
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