Nell1 as Target Antigen for Mercury Related Membranous Nephropathy: A Case Report
Membranous nephropathy constitutes 30% of adult nephrotic syndrome. Of all cases of membranous nephropathy, primary membranous nephropathy is commonest. Mercury is known to be a cause of secondary membranous nephropathy. There is no human data on the pathophysiology of mercury-related membranous nep...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Nephrology |
| Subjects: | |
| Online Access: | http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2022;volume=32;issue=5;spage=502;epage=505;aulast=Pathak |
| _version_ | 1797963408568483840 |
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| author | Nabadwip Pathak Indra Gunasekaran Moses Ambriose Sunil Kumar Nanda |
| author_facet | Nabadwip Pathak Indra Gunasekaran Moses Ambriose Sunil Kumar Nanda |
| author_sort | Nabadwip Pathak |
| collection | DOAJ |
| description | Membranous nephropathy constitutes 30% of adult nephrotic syndrome. Of all cases of membranous nephropathy, primary membranous nephropathy is commonest. Mercury is known to be a cause of secondary membranous nephropathy. There is no human data on the pathophysiology of mercury-related membranous nephropathy, but animal studies suggested an autoimmune mechanism behind it. There is no data to the best of our knowledge about target antigen for mercury-related membranous nephropathy. We are reporting a case of NELL-1 positive mercury-related membranous nephropathy that started resolving after stopping siddha medication and taking antiproteinuric. There was also concomitant euthyroid lymphocytic thyroiditis with anti-TPO positive, which started after exposure to siddha medication, which suggests systemic autoimmune phenomenon due to mercury exposure. |
| first_indexed | 2024-04-11T01:27:53Z |
| format | Article |
| id | doaj.art-1647df586e434976a73b0547487fc432 |
| institution | Directory Open Access Journal |
| issn | 0971-4065 1998-3662 |
| language | English |
| last_indexed | 2024-04-11T01:27:53Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Nephrology |
| spelling | doaj.art-1647df586e434976a73b0547487fc4322023-01-03T10:05:09ZengWolters Kluwer Medknow PublicationsIndian Journal of Nephrology0971-40651998-36622022-01-0132550250510.4103/ijn.ijn_415_21Nell1 as Target Antigen for Mercury Related Membranous Nephropathy: A Case ReportNabadwip PathakIndra GunasekaranMoses AmbrioseSunil Kumar NandaMembranous nephropathy constitutes 30% of adult nephrotic syndrome. Of all cases of membranous nephropathy, primary membranous nephropathy is commonest. Mercury is known to be a cause of secondary membranous nephropathy. There is no human data on the pathophysiology of mercury-related membranous nephropathy, but animal studies suggested an autoimmune mechanism behind it. There is no data to the best of our knowledge about target antigen for mercury-related membranous nephropathy. We are reporting a case of NELL-1 positive mercury-related membranous nephropathy that started resolving after stopping siddha medication and taking antiproteinuric. There was also concomitant euthyroid lymphocytic thyroiditis with anti-TPO positive, which started after exposure to siddha medication, which suggests systemic autoimmune phenomenon due to mercury exposure.http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2022;volume=32;issue=5;spage=502;epage=505;aulast=Pathakmembranous nephropathymercurynell-1secondary membranous |
| spellingShingle | Nabadwip Pathak Indra Gunasekaran Moses Ambriose Sunil Kumar Nanda Nell1 as Target Antigen for Mercury Related Membranous Nephropathy: A Case Report Indian Journal of Nephrology membranous nephropathy mercury nell-1 secondary membranous |
| title | Nell1 as Target Antigen for Mercury Related Membranous Nephropathy: A Case Report |
| title_full | Nell1 as Target Antigen for Mercury Related Membranous Nephropathy: A Case Report |
| title_fullStr | Nell1 as Target Antigen for Mercury Related Membranous Nephropathy: A Case Report |
| title_full_unstemmed | Nell1 as Target Antigen for Mercury Related Membranous Nephropathy: A Case Report |
| title_short | Nell1 as Target Antigen for Mercury Related Membranous Nephropathy: A Case Report |
| title_sort | nell1 as target antigen for mercury related membranous nephropathy a case report |
| topic | membranous nephropathy mercury nell-1 secondary membranous |
| url | http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2022;volume=32;issue=5;spage=502;epage=505;aulast=Pathak |
| work_keys_str_mv | AT nabadwippathak nell1astargetantigenformercuryrelatedmembranousnephropathyacasereport AT indragunasekaran nell1astargetantigenformercuryrelatedmembranousnephropathyacasereport AT mosesambriose nell1astargetantigenformercuryrelatedmembranousnephropathyacasereport AT sunilkumarnanda nell1astargetantigenformercuryrelatedmembranousnephropathyacasereport |