Relationship between Residual Urine Output and Type of Dialysis with FGF23 Levels
Several studies investigated the role of fibroblast growth factor 23 (FGF23) in the regulation of renal phosphate excretion in chronic kidney disease (CKD). However, patients with residual urine output (UO) seem to control their serum phosphorus levels better. Our aim was to determine whether FGF23...
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MDPI AG
2022-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/1/222 |
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| author | Valentina Corradi Sara Samoni Alice Mariotto Carlotta Caprara Elisa Scalzotto Anna Chiara Frigo Francesca K. Martino Davide Giavarina Claudio Ronco Monica Zanella |
| author_facet | Valentina Corradi Sara Samoni Alice Mariotto Carlotta Caprara Elisa Scalzotto Anna Chiara Frigo Francesca K. Martino Davide Giavarina Claudio Ronco Monica Zanella |
| author_sort | Valentina Corradi |
| collection | DOAJ |
| description | Several studies investigated the role of fibroblast growth factor 23 (FGF23) in the regulation of renal phosphate excretion in chronic kidney disease (CKD). However, patients with residual urine output (UO) seem to control their serum phosphorus levels better. Our aim was to determine whether FGF23 levels are influenced by dialysis modality and UO. We performed a cross-sectional study in hemodialysis (HD) and peritoneal dialysis (PD) patients. The C-terminal FGF23 (cFGF23) levels were determined in plasma with a two-site enzyme-linked immunosorbent assay. The UO collection referred to an mL/day measurement. All <i>p</i> values were two-sided, and the statistical significance was set at <i>p</i> < 0.05. We enrolled 133 patients (58 HD, 75 PD, UO 70%). The median cFGF23 was significantly higher in HD vs. PD patients (<i>p</i> = 0.0017) and not significantly higher in patients without UO (<i>p</i> = 0.12). We found a negative correlation between cFGF23 and the UO volume (<i>p</i> = 0.0250), but the correlation was not significant when considering the type of dialysis treatment. Phosphorus (ß = 0.21677; <i>p</i> = 0.0007), type of dialysis (ß = −0.68392; <i>p</i> = 0.0003), and creatinine (ß = 0.08130; <i>p</i> = 0.0133) were significant and independent predictors of cFGF23 levels. In conclusion, cFGF23 was significantly higher in HD than in PD patients. We found a significant negative correlation between cFGF23 and the residual UO volume, but the correlation was not significant considering the type of dialysis. Our study reveals that dialysis modality is an independent predictor of FGF23 levels. In particular, PD is associated with lower FGF23 levels than HD. |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T09:56:36Z |
| publishDate | 2022-12-01 |
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| spelling | doaj.art-1649f7d18f384780bb5bda069c1485c42023-11-16T15:43:07ZengMDPI AGJournal of Clinical Medicine2077-03832022-12-0112122210.3390/jcm12010222Relationship between Residual Urine Output and Type of Dialysis with FGF23 LevelsValentina Corradi0Sara Samoni1Alice Mariotto2Carlotta Caprara3Elisa Scalzotto4Anna Chiara Frigo5Francesca K. Martino6Davide Giavarina7Claudio Ronco8Monica Zanella9Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, AULSS 8 BERICA Vicenza, 36100 Vicenza, ItalyInternational Renal Research Institute of Vicenza and IRRIV Foundation for Research, San Bortolo Hospital, AULSS 8 BERICA Vicenza, 36100 Vicenza, ItalyDepartment of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, AULSS 8 BERICA Vicenza, 36100 Vicenza, ItalyDepartment of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, AULSS 8 BERICA Vicenza, 36100 Vicenza, ItalyInternational Renal Research Institute of Vicenza and IRRIV Foundation for Research, San Bortolo Hospital, AULSS 8 BERICA Vicenza, 36100 Vicenza, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35122 Padua, ItalyDepartment of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, AULSS 8 BERICA Vicenza, 36100 Vicenza, ItalyDepartment of Laboratory Medicine, San Bortolo Hospital, AULSS 8 BERICA Vicenza, 36100 Vicenza, ItalyInternational Renal Research Institute of Vicenza and IRRIV Foundation for Research, San Bortolo Hospital, AULSS 8 BERICA Vicenza, 36100 Vicenza, ItalyDepartment of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, AULSS 8 BERICA Vicenza, 36100 Vicenza, ItalySeveral studies investigated the role of fibroblast growth factor 23 (FGF23) in the regulation of renal phosphate excretion in chronic kidney disease (CKD). However, patients with residual urine output (UO) seem to control their serum phosphorus levels better. Our aim was to determine whether FGF23 levels are influenced by dialysis modality and UO. We performed a cross-sectional study in hemodialysis (HD) and peritoneal dialysis (PD) patients. The C-terminal FGF23 (cFGF23) levels were determined in plasma with a two-site enzyme-linked immunosorbent assay. The UO collection referred to an mL/day measurement. All <i>p</i> values were two-sided, and the statistical significance was set at <i>p</i> < 0.05. We enrolled 133 patients (58 HD, 75 PD, UO 70%). The median cFGF23 was significantly higher in HD vs. PD patients (<i>p</i> = 0.0017) and not significantly higher in patients without UO (<i>p</i> = 0.12). We found a negative correlation between cFGF23 and the UO volume (<i>p</i> = 0.0250), but the correlation was not significant when considering the type of dialysis treatment. Phosphorus (ß = 0.21677; <i>p</i> = 0.0007), type of dialysis (ß = −0.68392; <i>p</i> = 0.0003), and creatinine (ß = 0.08130; <i>p</i> = 0.0133) were significant and independent predictors of cFGF23 levels. In conclusion, cFGF23 was significantly higher in HD than in PD patients. We found a significant negative correlation between cFGF23 and the residual UO volume, but the correlation was not significant considering the type of dialysis. Our study reveals that dialysis modality is an independent predictor of FGF23 levels. In particular, PD is associated with lower FGF23 levels than HD.https://www.mdpi.com/2077-0383/12/1/222hyperphosphatemiafibroblast growth factor 23 (FGF23)residual urine output (UO)chronic kidney disease (CKD)hemodialysis (HD)peritoneal dialysis (PD) |
| spellingShingle | Valentina Corradi Sara Samoni Alice Mariotto Carlotta Caprara Elisa Scalzotto Anna Chiara Frigo Francesca K. Martino Davide Giavarina Claudio Ronco Monica Zanella Relationship between Residual Urine Output and Type of Dialysis with FGF23 Levels Journal of Clinical Medicine hyperphosphatemia fibroblast growth factor 23 (FGF23) residual urine output (UO) chronic kidney disease (CKD) hemodialysis (HD) peritoneal dialysis (PD) |
| title | Relationship between Residual Urine Output and Type of Dialysis with FGF23 Levels |
| title_full | Relationship between Residual Urine Output and Type of Dialysis with FGF23 Levels |
| title_fullStr | Relationship between Residual Urine Output and Type of Dialysis with FGF23 Levels |
| title_full_unstemmed | Relationship between Residual Urine Output and Type of Dialysis with FGF23 Levels |
| title_short | Relationship between Residual Urine Output and Type of Dialysis with FGF23 Levels |
| title_sort | relationship between residual urine output and type of dialysis with fgf23 levels |
| topic | hyperphosphatemia fibroblast growth factor 23 (FGF23) residual urine output (UO) chronic kidney disease (CKD) hemodialysis (HD) peritoneal dialysis (PD) |
| url | https://www.mdpi.com/2077-0383/12/1/222 |
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