The Effect of HIV/AIDS Infection on the Clinical Outcomes of COVID-19: A Meta-Analysis
Purpose: Patients with HIV may be more likely to become severely ill from COVID-19. The present meta-analysis aims to determine the impact of HIV/AIDS infection on the clinical outcomes of COVID-19. Methods: A comprehensive literature search was performed to identify relevant cohort studies to eval...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Journal of Pharmacy & Pharmaceutical Sciences |
| Online Access: | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/32831 |
| _version_ | 1797756892439642112 |
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| author | Yousef Moradi Marzieh Soheili Hojat Dehghanbanadaki Ghobad Moradi Farhad Moradpour Seyede Maryam Mahdavi Mortazavi Hamed Gilzad Kohan Mostafa Zareie |
| author_facet | Yousef Moradi Marzieh Soheili Hojat Dehghanbanadaki Ghobad Moradi Farhad Moradpour Seyede Maryam Mahdavi Mortazavi Hamed Gilzad Kohan Mostafa Zareie |
| author_sort | Yousef Moradi |
| collection | DOAJ |
| description |
Purpose: Patients with HIV may be more likely to become severely ill from COVID-19. The present meta-analysis aims to determine the impact of HIV/AIDS infection on the clinical outcomes of COVID-19. Methods: A comprehensive literature search was performed to identify relevant cohort studies to evaluate the association of HIV/AIDS infection with clinical outcomes of COVID-19. International databases, including PubMed (Medline), Web of Sciences, Scopus, and Embase, were searched from the emergence of the COVID-19 pandemic until January 2022. We utilized the risk ratio (RR) with its 95% confidence interval (95% CI) to quantify the effect of cohort studies. Results: Twelve cohort studies were included in this meta-analysis, which examined a total number of 17,786,384 patients. Among them, 40,386 were identified to be HIV positive, and 17,745,998 were HIV negative. The pooled analyses showed HIV positive patients who were co-infected with SARS-CoV-2 were 58% more likely to develop a fever (RR=1.58; 95% CI: 1.42, 1.75), 24% more likely to have dyspnea (RR=1.24; 95% CI: 1.08, 1.41), 45% more likely to be admitted to ICU (RR=1.45; 95% CI: 1.26, 1.67), and 37% more likely to die from to COVID-19 (RR=1.37; 95% CI: 1.30, 1.45) than HIV negative patients. Conclusion: HIV/AIDS coinfection with COVID 19 increased the risk of fever, dyspnea, ICU admission, and mortality.
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| first_indexed | 2024-03-12T18:08:03Z |
| format | Article |
| id | doaj.art-1649faecf18c448bac943dffe1e5bf73 |
| institution | Directory Open Access Journal |
| issn | 1482-1826 |
| language | English |
| last_indexed | 2024-03-12T18:08:03Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmaceutical Sciences |
| spelling | doaj.art-1649faecf18c448bac943dffe1e5bf732023-08-02T09:24:25ZengFrontiers Media S.A.Journal of Pharmacy & Pharmaceutical Sciences1482-18262022-06-012510.18433/jpps32831The Effect of HIV/AIDS Infection on the Clinical Outcomes of COVID-19: A Meta-AnalysisYousef MoradiMarzieh Soheili0Hojat Dehghanbanadaki1Ghobad Moradi2Farhad Moradpour3Seyede Maryam Mahdavi Mortazavi4Hamed Gilzad Kohan5Mostafa Zareie6Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Epidemiology and Biostatistics, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. Pediatric Gastroenterology Fellowship, Department of Pediatrics, School of Medicine, Namazi teaching Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. Western New England UniversityCollege of PharmacyDepartment of Pharmaceutical and Administrative SciencesSocial Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. Purpose: Patients with HIV may be more likely to become severely ill from COVID-19. The present meta-analysis aims to determine the impact of HIV/AIDS infection on the clinical outcomes of COVID-19. Methods: A comprehensive literature search was performed to identify relevant cohort studies to evaluate the association of HIV/AIDS infection with clinical outcomes of COVID-19. International databases, including PubMed (Medline), Web of Sciences, Scopus, and Embase, were searched from the emergence of the COVID-19 pandemic until January 2022. We utilized the risk ratio (RR) with its 95% confidence interval (95% CI) to quantify the effect of cohort studies. Results: Twelve cohort studies were included in this meta-analysis, which examined a total number of 17,786,384 patients. Among them, 40,386 were identified to be HIV positive, and 17,745,998 were HIV negative. The pooled analyses showed HIV positive patients who were co-infected with SARS-CoV-2 were 58% more likely to develop a fever (RR=1.58; 95% CI: 1.42, 1.75), 24% more likely to have dyspnea (RR=1.24; 95% CI: 1.08, 1.41), 45% more likely to be admitted to ICU (RR=1.45; 95% CI: 1.26, 1.67), and 37% more likely to die from to COVID-19 (RR=1.37; 95% CI: 1.30, 1.45) than HIV negative patients. Conclusion: HIV/AIDS coinfection with COVID 19 increased the risk of fever, dyspnea, ICU admission, and mortality. https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/32831 |
| spellingShingle | Yousef Moradi Marzieh Soheili Hojat Dehghanbanadaki Ghobad Moradi Farhad Moradpour Seyede Maryam Mahdavi Mortazavi Hamed Gilzad Kohan Mostafa Zareie The Effect of HIV/AIDS Infection on the Clinical Outcomes of COVID-19: A Meta-Analysis Journal of Pharmacy & Pharmaceutical Sciences |
| title | The Effect of HIV/AIDS Infection on the Clinical Outcomes of COVID-19: A Meta-Analysis |
| title_full | The Effect of HIV/AIDS Infection on the Clinical Outcomes of COVID-19: A Meta-Analysis |
| title_fullStr | The Effect of HIV/AIDS Infection on the Clinical Outcomes of COVID-19: A Meta-Analysis |
| title_full_unstemmed | The Effect of HIV/AIDS Infection on the Clinical Outcomes of COVID-19: A Meta-Analysis |
| title_short | The Effect of HIV/AIDS Infection on the Clinical Outcomes of COVID-19: A Meta-Analysis |
| title_sort | effect of hiv aids infection on the clinical outcomes of covid 19 a meta analysis |
| url | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/32831 |
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