R-Loop Formation in Meiosis: Roles in Meiotic Transcription-Associated DNA Damage

R-Loop Formation in Meiosis: Roles in Meiotic Transcription-Associated DNA Damage

Meiosis is specialized cell division during gametogenesis that produces genetically unique gametes via homologous recombination. Meiotic homologous recombination entails repairing programmed 200–300 DNA double-strand breaks generated during the early prophase. To avoid interference between meiotic g...

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Bibliographic Details
Main Authors: Yasuhiro Fujiwara, Mary Ann Handel, Yuki Okada
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Epigenomes
Subjects:
DNA damage
homologous recombination
gametogenesis
meiosis
R-loops
spermatogenesis
Online Access:https://www.mdpi.com/2075-4655/6/3/26

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