Pulmonary Function Assessment in Myasthenia Gravis Patients in a National Referral Hospital in Indonesia
Fitri Octaviana,1,2 Ahmad Yanuar Safri,1,2 Winnugroho Wiratman,1– 3 Luh Ari Indrawati,1,2 Nurul Fadli,1,3 Manfaluthy Hakim1,2 1Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; 2Department of Neurology, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; 3...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-10-01
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| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/pulmonary-function-assessment-in-myasthenia-gravis-patients-in-a-natio-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1797659019225071616 |
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| author | Octaviana F Safri AY Wiratman W Indrawati LA Fadli N Hakim M |
| author_facet | Octaviana F Safri AY Wiratman W Indrawati LA Fadli N Hakim M |
| author_sort | Octaviana F |
| collection | DOAJ |
| description | Fitri Octaviana,1,2 Ahmad Yanuar Safri,1,2 Winnugroho Wiratman,1– 3 Luh Ari Indrawati,1,2 Nurul Fadli,1,3 Manfaluthy Hakim1,2 1Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; 2Department of Neurology, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; 3Universitas Indonesia Hospital, Depok, IndonesiaCorrespondence: Fitri Octaviana, Email fitri.octaviana@ui.ac.idPurpose: Myasthenia gravis (MG) can cause respiratory muscle weakness and the need of ventilator support. Spirometry as the gold standard for pulmonary function examination has limited availability, especially in our hospital which is only available in outpatient clinic during work hours (not in emergency room or patient room). Furthermore, all primary healthcare in Indonesia do not have spirometry equipment, thus other alternatives are required. This study aimed to analyze the relationship between a single breath counting test (SBCT), peak flow meter (PFM), and spirometry to assess pulmonary function in MG patients in a national referral hospital in Indonesia.Patients and Methods: A single-center, cross-sectional study was conducted and SBCT, PFM, and spirometry examination were performed in MG patients and healthy controls.Results: Seventy patients, aged 47.7 ± 13.4 years old, participated in this study. SBCT, forced vital capacity first second (FVC1), and forced expiratory volume first second (FEV1) value between MG patients and healthy controls showed a significant difference, in which healthy controls have higher SBCT, FVC1, and FEV1 values (p = 0.000, p = 0.000 and p = 0.001 respectively). There was a significant difference between PFM with SBCT and FVC1 value in MG patients. Strong correlation was found between SBCT and FVC1 in MG patients.Conclusion: MG patients had worse pulmonary function compared to healthy controls. SBCT and PFM examination have a significant correlation with FVC1 in MG patients. Therefore, SBCT and PFM can be used as a bedside tool to detect respiratory impairment in MG patients.Keywords: myasthenia gravis, peak flow meter, single breath counting test, spirometry |
| first_indexed | 2024-03-11T18:07:55Z |
| format | Article |
| id | doaj.art-164c0c4a56b243bfb6e201d05f555c45 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-03-11T18:07:55Z |
| publishDate | 2023-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-164c0c4a56b243bfb6e201d05f555c452023-10-17T02:42:29ZengDove Medical PressInternational Journal of General Medicine1178-70742023-10-01Volume 164477448387127Pulmonary Function Assessment in Myasthenia Gravis Patients in a National Referral Hospital in IndonesiaOctaviana FSafri AYWiratman WIndrawati LAFadli NHakim MFitri Octaviana,1,2 Ahmad Yanuar Safri,1,2 Winnugroho Wiratman,1– 3 Luh Ari Indrawati,1,2 Nurul Fadli,1,3 Manfaluthy Hakim1,2 1Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; 2Department of Neurology, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; 3Universitas Indonesia Hospital, Depok, IndonesiaCorrespondence: Fitri Octaviana, Email fitri.octaviana@ui.ac.idPurpose: Myasthenia gravis (MG) can cause respiratory muscle weakness and the need of ventilator support. Spirometry as the gold standard for pulmonary function examination has limited availability, especially in our hospital which is only available in outpatient clinic during work hours (not in emergency room or patient room). Furthermore, all primary healthcare in Indonesia do not have spirometry equipment, thus other alternatives are required. This study aimed to analyze the relationship between a single breath counting test (SBCT), peak flow meter (PFM), and spirometry to assess pulmonary function in MG patients in a national referral hospital in Indonesia.Patients and Methods: A single-center, cross-sectional study was conducted and SBCT, PFM, and spirometry examination were performed in MG patients and healthy controls.Results: Seventy patients, aged 47.7 ± 13.4 years old, participated in this study. SBCT, forced vital capacity first second (FVC1), and forced expiratory volume first second (FEV1) value between MG patients and healthy controls showed a significant difference, in which healthy controls have higher SBCT, FVC1, and FEV1 values (p = 0.000, p = 0.000 and p = 0.001 respectively). There was a significant difference between PFM with SBCT and FVC1 value in MG patients. Strong correlation was found between SBCT and FVC1 in MG patients.Conclusion: MG patients had worse pulmonary function compared to healthy controls. SBCT and PFM examination have a significant correlation with FVC1 in MG patients. Therefore, SBCT and PFM can be used as a bedside tool to detect respiratory impairment in MG patients.Keywords: myasthenia gravis, peak flow meter, single breath counting test, spirometryhttps://www.dovepress.com/pulmonary-function-assessment-in-myasthenia-gravis-patients-in-a-natio-peer-reviewed-fulltext-article-IJGMmyasthenia gravispeak flow metersingle breath counting testspirometry |
| spellingShingle | Octaviana F Safri AY Wiratman W Indrawati LA Fadli N Hakim M Pulmonary Function Assessment in Myasthenia Gravis Patients in a National Referral Hospital in Indonesia International Journal of General Medicine myasthenia gravis peak flow meter single breath counting test spirometry |
| title | Pulmonary Function Assessment in Myasthenia Gravis Patients in a National Referral Hospital in Indonesia |
| title_full | Pulmonary Function Assessment in Myasthenia Gravis Patients in a National Referral Hospital in Indonesia |
| title_fullStr | Pulmonary Function Assessment in Myasthenia Gravis Patients in a National Referral Hospital in Indonesia |
| title_full_unstemmed | Pulmonary Function Assessment in Myasthenia Gravis Patients in a National Referral Hospital in Indonesia |
| title_short | Pulmonary Function Assessment in Myasthenia Gravis Patients in a National Referral Hospital in Indonesia |
| title_sort | pulmonary function assessment in myasthenia gravis patients in a national referral hospital in indonesia |
| topic | myasthenia gravis peak flow meter single breath counting test spirometry |
| url | https://www.dovepress.com/pulmonary-function-assessment-in-myasthenia-gravis-patients-in-a-natio-peer-reviewed-fulltext-article-IJGM |
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