Giant Intracranial Xanthoma with Cloudy Vision as the First Symptom: A Case Report and Literature Review
Xueting Wang,1,2 Xuejiao Li,2 XuHui Liu,3 Yizhe Yin,1 Yalong Dang,2 Fang Lei1 1Department of Ophthalmology, Henan University of Science and Technology School of Medicine, Luoyang, Henan, 471000, People’s Republic of China; 2Sanmenxia Central Hospital, Henan University of Science and Techno...
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Dove Medical Press
2021-03-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/giant-intracranial-xanthoma-with-cloudy-vision-as-the-first-symptom-a--peer-reviewed-article-IJGM |
| _version_ | 1818615634734350336 |
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| author | Wang X Li X Liu X Yin Y Dang Y Lei F |
| author_facet | Wang X Li X Liu X Yin Y Dang Y Lei F |
| author_sort | Wang X |
| collection | DOAJ |
| description | Xueting Wang,1,2 Xuejiao Li,2 XuHui Liu,3 Yizhe Yin,1 Yalong Dang,2 Fang Lei1 1Department of Ophthalmology, Henan University of Science and Technology School of Medicine, Luoyang, Henan, 471000, People’s Republic of China; 2Sanmenxia Central Hospital, Henan University of Science and Technology, Sanmenxia, Henan, 472000, People’s Republic of China; 3Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450001, People’s Republic of ChinaCorrespondence: Yalong Dang; Fang Lei Tel +86-398-3118149; +86-379-64231886Email dangyalong@haust.edu.cn; leifang@haust.edu.cnAbstract: A 31-year-old male with mild dizziness complained of cloudy vision in his right eye for 5 days. The visual acuity of both eyes was normal, while the visual contrast sensitivity of both eyes slightly reduced. Fundus examination showed the swollen and radial superficial hemorrhage of his both optic nerves. Brain MRI scan indicated a huge tumor in the right temporal lobe with clear boundary, close to the skull. The midline structure shifted to the left. Blood tests indicated no hyperlipidemia or lipid disorders. The patient then received tumor resection. The size of the tumor was 5.6 cm × 7.5 cm × 10.1 cm. Histology suggested many foam cell accumulations and the tumor was positive for CD34, CD99, Vimentin, β-Catenin and CD68, but negative for EMA, GFAP, IDH-1, Oliga-2, PR, S-100, and CD1a. Three months after surgery, MRI showed the midline structure was back to normal. The swollen and radial superficial hemorrhage of optic nerves had disappeared. The visual acuity and visual field remained normal.Keywords: intracranial xanthoma, optic nerve, visual function, neurological disorder, optic disc edema |
| first_indexed | 2024-12-16T16:37:02Z |
| format | Article |
| id | doaj.art-164dc3fb9b4042a29020893dff2ec8ae |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-12-16T16:37:02Z |
| publishDate | 2021-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-164dc3fb9b4042a29020893dff2ec8ae2022-12-21T22:24:26ZengDove Medical PressInternational Journal of General Medicine1178-70742021-03-01Volume 141101110563422Giant Intracranial Xanthoma with Cloudy Vision as the First Symptom: A Case Report and Literature ReviewWang XLi XLiu XYin YDang YLei FXueting Wang,1,2 Xuejiao Li,2 XuHui Liu,3 Yizhe Yin,1 Yalong Dang,2 Fang Lei1 1Department of Ophthalmology, Henan University of Science and Technology School of Medicine, Luoyang, Henan, 471000, People’s Republic of China; 2Sanmenxia Central Hospital, Henan University of Science and Technology, Sanmenxia, Henan, 472000, People’s Republic of China; 3Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450001, People’s Republic of ChinaCorrespondence: Yalong Dang; Fang Lei Tel +86-398-3118149; +86-379-64231886Email dangyalong@haust.edu.cn; leifang@haust.edu.cnAbstract: A 31-year-old male with mild dizziness complained of cloudy vision in his right eye for 5 days. The visual acuity of both eyes was normal, while the visual contrast sensitivity of both eyes slightly reduced. Fundus examination showed the swollen and radial superficial hemorrhage of his both optic nerves. Brain MRI scan indicated a huge tumor in the right temporal lobe with clear boundary, close to the skull. The midline structure shifted to the left. Blood tests indicated no hyperlipidemia or lipid disorders. The patient then received tumor resection. The size of the tumor was 5.6 cm × 7.5 cm × 10.1 cm. Histology suggested many foam cell accumulations and the tumor was positive for CD34, CD99, Vimentin, β-Catenin and CD68, but negative for EMA, GFAP, IDH-1, Oliga-2, PR, S-100, and CD1a. Three months after surgery, MRI showed the midline structure was back to normal. The swollen and radial superficial hemorrhage of optic nerves had disappeared. The visual acuity and visual field remained normal.Keywords: intracranial xanthoma, optic nerve, visual function, neurological disorder, optic disc edemahttps://www.dovepress.com/giant-intracranial-xanthoma-with-cloudy-vision-as-the-first-symptom-a--peer-reviewed-article-IJGMintracranial xanthomaoptic nervevisual functionneurological disorderoptic disc edema |
| spellingShingle | Wang X Li X Liu X Yin Y Dang Y Lei F Giant Intracranial Xanthoma with Cloudy Vision as the First Symptom: A Case Report and Literature Review International Journal of General Medicine intracranial xanthoma optic nerve visual function neurological disorder optic disc edema |
| title | Giant Intracranial Xanthoma with Cloudy Vision as the First Symptom: A Case Report and Literature Review |
| title_full | Giant Intracranial Xanthoma with Cloudy Vision as the First Symptom: A Case Report and Literature Review |
| title_fullStr | Giant Intracranial Xanthoma with Cloudy Vision as the First Symptom: A Case Report and Literature Review |
| title_full_unstemmed | Giant Intracranial Xanthoma with Cloudy Vision as the First Symptom: A Case Report and Literature Review |
| title_short | Giant Intracranial Xanthoma with Cloudy Vision as the First Symptom: A Case Report and Literature Review |
| title_sort | giant intracranial xanthoma with cloudy vision as the first symptom a case report and literature review |
| topic | intracranial xanthoma optic nerve visual function neurological disorder optic disc edema |
| url | https://www.dovepress.com/giant-intracranial-xanthoma-with-cloudy-vision-as-the-first-symptom-a--peer-reviewed-article-IJGM |
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