Reduced toxicity conditioning and a high CD34+ cell dose can achieve full donor chimerism in DOCK8 deficiency

Reduced toxicity conditioning and a high CD34+ cell dose can achieve full donor chimerism in DOCK8 deficiency

Background: Biallelic mutations in the dedicator of cytokinesis 8 (DOCK8) gene were identified as the cause of combined immunodeficiency in 2009. Survival rates without hematopoietic stem cell transplant in patients with DOCK8 deficiency decline from 87% at 10 years to 33% at 30 years. Hematopoietic...

Full description

Bibliographic Details
Main Authors: Ambreen Pandrowala, MBBS, DNB (Paediatrics), Ajay Narayan Sharma, MBBS, DNB (Paediatrics), Manasa Kakunje, MBBS, DNB (Paediatrics), Minnie Bodhanwala, BDS, MBA, Prashant Hiwarkar, MD, FRCPath, PhD
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Journal of Allergy and Clinical Immunology: Global
Subjects:
DOCK8 deficiency
bone marrow transplantation
HSCT
chimerism
Online Access:http://www.sciencedirect.com/science/article/pii/S2772829323000310

Similar Items

Similar Items