Regulation of cGAS‐Mediated Immune Responses and Immunotherapy
Abstract Early detection of infectious nucleic acids released from invading pathogens by the innate immune system is critical for immune defense. Detection of these nucleic acids by host immune sensors and regulation of DNA sensing pathways have been significant interests in the past years. Here, cu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-03-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.201902599 |
| _version_ | 1828228809635135488 |
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| author | Abdullah F. U. H. Saeed Xinglin Ruan Hongxin Guan Jingqian Su Songying Ouyang |
| author_facet | Abdullah F. U. H. Saeed Xinglin Ruan Hongxin Guan Jingqian Su Songying Ouyang |
| author_sort | Abdullah F. U. H. Saeed |
| collection | DOAJ |
| description | Abstract Early detection of infectious nucleic acids released from invading pathogens by the innate immune system is critical for immune defense. Detection of these nucleic acids by host immune sensors and regulation of DNA sensing pathways have been significant interests in the past years. Here, current understandings of evolutionarily conserved DNA sensing cyclic GMP‐AMP (cGAMP) synthase (cGAS) are highlighted. Precise activation and tight regulation of cGAS are vital in appropriate innate immune responses, senescence, tumorigenesis and immunotherapy, and autoimmunity. Hence, substantial insights into cytosolic DNA sensing and immunotherapy of indispensable cytosolic sensors have been detailed to extend limited knowledge available thus far. This Review offers a critical, in‐depth understanding of cGAS regulation, cytosolic DNA sensing, and currently established therapeutic approaches of essential cytosolic immune agents for improved human health. |
| first_indexed | 2024-04-12T18:25:08Z |
| format | Article |
| id | doaj.art-1652b6b11c594a69850643e1ebeca20f |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-12T18:25:08Z |
| publishDate | 2020-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-1652b6b11c594a69850643e1ebeca20f2022-12-22T03:21:15ZengWileyAdvanced Science2198-38442020-03-0176n/an/a10.1002/advs.201902599Regulation of cGAS‐Mediated Immune Responses and ImmunotherapyAbdullah F. U. H. Saeed0Xinglin Ruan1Hongxin Guan2Jingqian Su3Songying Ouyang4The Key Laboratory of Innate Immune Biology of Fujian Province Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation Biomedical Research Center of South China Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education College of Life Sciences Fujian Normal University Fuzhou 350117 ChinaDepartment of Neurology Fujian Medical University Union Hospital 29 Xinquan Road Gulou District Fuzhou 350001 ChinaThe Key Laboratory of Innate Immune Biology of Fujian Province Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation Biomedical Research Center of South China Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education College of Life Sciences Fujian Normal University Fuzhou 350117 ChinaThe Key Laboratory of Innate Immune Biology of Fujian Province Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation Biomedical Research Center of South China Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education College of Life Sciences Fujian Normal University Fuzhou 350117 ChinaThe Key Laboratory of Innate Immune Biology of Fujian Province Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation Biomedical Research Center of South China Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education College of Life Sciences Fujian Normal University Fuzhou 350117 ChinaAbstract Early detection of infectious nucleic acids released from invading pathogens by the innate immune system is critical for immune defense. Detection of these nucleic acids by host immune sensors and regulation of DNA sensing pathways have been significant interests in the past years. Here, current understandings of evolutionarily conserved DNA sensing cyclic GMP‐AMP (cGAMP) synthase (cGAS) are highlighted. Precise activation and tight regulation of cGAS are vital in appropriate innate immune responses, senescence, tumorigenesis and immunotherapy, and autoimmunity. Hence, substantial insights into cytosolic DNA sensing and immunotherapy of indispensable cytosolic sensors have been detailed to extend limited knowledge available thus far. This Review offers a critical, in‐depth understanding of cGAS regulation, cytosolic DNA sensing, and currently established therapeutic approaches of essential cytosolic immune agents for improved human health.https://doi.org/10.1002/advs.201902599cGAS‐STINGcytosolic sensingimmunotherapyinnate immune regulationtumorigenesis |
| spellingShingle | Abdullah F. U. H. Saeed Xinglin Ruan Hongxin Guan Jingqian Su Songying Ouyang Regulation of cGAS‐Mediated Immune Responses and Immunotherapy Advanced Science cGAS‐STING cytosolic sensing immunotherapy innate immune regulation tumorigenesis |
| title | Regulation of cGAS‐Mediated Immune Responses and Immunotherapy |
| title_full | Regulation of cGAS‐Mediated Immune Responses and Immunotherapy |
| title_fullStr | Regulation of cGAS‐Mediated Immune Responses and Immunotherapy |
| title_full_unstemmed | Regulation of cGAS‐Mediated Immune Responses and Immunotherapy |
| title_short | Regulation of cGAS‐Mediated Immune Responses and Immunotherapy |
| title_sort | regulation of cgas mediated immune responses and immunotherapy |
| topic | cGAS‐STING cytosolic sensing immunotherapy innate immune regulation tumorigenesis |
| url | https://doi.org/10.1002/advs.201902599 |
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