Mepolizumab in the treatment of eosinophilic chronic obstructive pulmonary disease
Takudzwa Mkorombindo, Mark T DransfieldLung Health Center, Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USAAbstract: Despite maximal medical therapy, a subset of patients with chronic obstructive pulmonary dis...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-08-01
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| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/mepolizumab-in-the-treatment-of-eosinophilic-chronic-obstructive-pulmo-peer-reviewed-article-COPD |
| _version_ | 1818877067169628160 |
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| author | Mkorombindo T Dransfield MT |
| author_facet | Mkorombindo T Dransfield MT |
| author_sort | Mkorombindo T |
| collection | DOAJ |
| description | Takudzwa Mkorombindo, Mark T DransfieldLung Health Center, Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USAAbstract: Despite maximal medical therapy, a subset of patients with chronic obstructive pulmonary disease continue to suffer acute exacerbations. It is also clear that a subset of this population has elevated blood eosinophils. In addition to clearly responding better to inhaled corticosteroids, it is also possible that this subgroup may benefit from biologic treatments targeting eosinophilic inflammation. Mepolizumab, a humanized monoclonal antibody against interleukin-5 (IL-5), may have a therapeutic effect in a subgroup of patients with COPD and eosinophilic airway inflammation. In this review, we discuss the biologic rationale for mepolizumab targeting IL-5 in eosinophilic COPD as well as the results of recently published clinical trials.Keywords: COPD, acute exacerbations of COPD, eosinophils, mepolizumab |
| first_indexed | 2024-12-19T13:52:23Z |
| format | Article |
| id | doaj.art-1656d1da5c1a4507b24751711c9b18de |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-12-19T13:52:23Z |
| publishDate | 2019-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-1656d1da5c1a4507b24751711c9b18de2022-12-21T20:18:41ZengDove Medical PressInternational Journal of COPD1178-20052019-08-01Volume 141779178747704Mepolizumab in the treatment of eosinophilic chronic obstructive pulmonary diseaseMkorombindo TDransfield MTTakudzwa Mkorombindo, Mark T DransfieldLung Health Center, Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USAAbstract: Despite maximal medical therapy, a subset of patients with chronic obstructive pulmonary disease continue to suffer acute exacerbations. It is also clear that a subset of this population has elevated blood eosinophils. In addition to clearly responding better to inhaled corticosteroids, it is also possible that this subgroup may benefit from biologic treatments targeting eosinophilic inflammation. Mepolizumab, a humanized monoclonal antibody against interleukin-5 (IL-5), may have a therapeutic effect in a subgroup of patients with COPD and eosinophilic airway inflammation. In this review, we discuss the biologic rationale for mepolizumab targeting IL-5 in eosinophilic COPD as well as the results of recently published clinical trials.Keywords: COPD, acute exacerbations of COPD, eosinophils, mepolizumabhttps://www.dovepress.com/mepolizumab-in-the-treatment-of-eosinophilic-chronic-obstructive-pulmo-peer-reviewed-article-COPDCOPDAcute exacerbations of COPDEosinophilsMepolizumab |
| spellingShingle | Mkorombindo T Dransfield MT Mepolizumab in the treatment of eosinophilic chronic obstructive pulmonary disease International Journal of COPD COPD Acute exacerbations of COPD Eosinophils Mepolizumab |
| title | Mepolizumab in the treatment of eosinophilic chronic obstructive pulmonary disease |
| title_full | Mepolizumab in the treatment of eosinophilic chronic obstructive pulmonary disease |
| title_fullStr | Mepolizumab in the treatment of eosinophilic chronic obstructive pulmonary disease |
| title_full_unstemmed | Mepolizumab in the treatment of eosinophilic chronic obstructive pulmonary disease |
| title_short | Mepolizumab in the treatment of eosinophilic chronic obstructive pulmonary disease |
| title_sort | mepolizumab in the treatment of eosinophilic chronic obstructive pulmonary disease |
| topic | COPD Acute exacerbations of COPD Eosinophils Mepolizumab |
| url | https://www.dovepress.com/mepolizumab-in-the-treatment-of-eosinophilic-chronic-obstructive-pulmo-peer-reviewed-article-COPD |
| work_keys_str_mv | AT mkorombindot mepolizumabinthetreatmentofeosinophilicchronicobstructivepulmonarydisease AT dransfieldmt mepolizumabinthetreatmentofeosinophilicchronicobstructivepulmonarydisease |