ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells

ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells

Mitochondrial injury of tubular epithelial cells (TECs) is the key pathogenic event underlying various kidney diseases and a potential intervening target as well. Our previous study demonstrated that ING2 is ubiquitously expressed at tubulointerstitial area within kidneys, while its role in regulati...

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Bibliographic Details
Main Authors: Ying Yang, Chensheng Li, Xia Gu, Junhui Zhen, Suwei Zhu, Tingting Lv, Qiang Wan, Yi Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ING2
MRPL12
mitochondrial respiration
ubiquitination
tubular epithelial cells
kidney disease
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.700195/full

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