Targeting RPA promotes autophagic flux and the antitumor response to radiation in nasopharyngeal carcinoma

Targeting RPA promotes autophagic flux and the antitumor response to radiation in nasopharyngeal carcinoma

Abstract Background Autophagy is involved in nasopharyngeal carcinoma (NPC) radioresistance. Replication protein A 1 (RPA1) and RPA3, substrates of the RPA complex, are potential therapeutic targets for reversing NPC radioresistance. Nevertheless, the role of RPA in autophagy is not adequately under...

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Bibliographic Details
Main Authors: Yanchun Feng, Yingming Jiang, Jun Liu, Jiaqi Liu, Mengchen Shi, Junxiong Chen, Jingdan Zhang, Yu Tian, Xiangling Yang, Huanliang Liu
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Translational Medicine
Subjects:
RPA
Nasopharyngeal carcinoma
Autophagy
Radiotherapy
Online Access:https://doi.org/10.1186/s12967-023-04574-w

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