Inter-relationship between evolutions of the temporal trend of urinary iodine excretion with iodized salt accessibility and thyroid function in an exclusive cohort of mothers residing in a mild iodine-deficient region
Background & Aims: Maternal iodine deficiency (UIC<150 μg/L) is common in regions with borderline iodine sufficiency. Hence, exploring evolution of the temporal trend for UIC during pregnancy as well as impact of possible modifiers aids in defining the timing and the dose of iodide administ...
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| Format: | Article |
| Language: | English |
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Urmia University of Medical Sciences
2020-01-01
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| Series: | Journal of Research in Applied and Basic Medical Sciences |
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| Online Access: | http://ijrabms.umsu.ac.ir/article-1-91-en.html |
| _version_ | 1818348820340146176 |
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| author | rahim rostami |
| author_facet | rahim rostami |
| author_sort | rahim rostami |
| collection | DOAJ |
| description | Background & Aims: Maternal iodine deficiency (UIC<150 μg/L) is common in regions with borderline iodine sufficiency. Hence,
exploring evolution of the temporal trend for UIC during pregnancy as well as impact of possible modifiers aids in defining the timing
and the dose of iodide administration supplement during foetal development. The aim of present investigation was to evaluate the inter-
relationships between UIC and iodized salt accessibility and thyroid function as assessed by thyroid-stimulating hormone (TSH) in an
exclusive cohort of pregnant women depending on household salt as the predominant source of iodine intake.
Materials and Methods: Healthy pregnant women (n=95; gestation > 4 and < 8 weeks) and non-pregnant women (n=40) with similar
lifestyle and dietary habits were enrolled. UIC, TSH and table-salt iodine content were determined.
Results: Median UIC (μg/L) according to trimesters was significantly lower than that of controls (61.6, 130.2 and 90.3 vs 133.8).
Accordingly, prevalence of subjects with UIC<150 μg/L were 97.9, 67.4, 77.9 and 60. Median TSH (mIU/L) according to trimesters
and control group were 1, 1.6, 1.4 and 1.6. Accordingly, prevalence of subjects with abnormal lower TSH limit was 17.2, 8.5, 3.2 and
2.4.
Conclusion: This investigation demonstrates that UIC varies according to the foetal life cycle and that the highest frequencies of severe
iodine (UIC <50 μg/L) were identified at the first- and third trimesters. This investigation paves the way for future studies aiming at
exploring the therapeutic impact of iodine supplementation on body iodine stores during pregnancy. |
| first_indexed | 2024-12-13T17:56:08Z |
| format | Article |
| id | doaj.art-165b3127f8de414f9f0cf5b0e3513936 |
| institution | Directory Open Access Journal |
| issn | 2717-0098 |
| language | English |
| last_indexed | 2024-12-13T17:56:08Z |
| publishDate | 2020-01-01 |
| publisher | Urmia University of Medical Sciences |
| record_format | Article |
| series | Journal of Research in Applied and Basic Medical Sciences |
| spelling | doaj.art-165b3127f8de414f9f0cf5b0e35139362022-12-21T23:36:22ZengUrmia University of Medical SciencesJournal of Research in Applied and Basic Medical Sciences2717-00982020-01-016118doi:10.http://ijrabms.umsu.ac.ir/article-1-91-en.pdfInter-relationship between evolutions of the temporal trend of urinary iodine excretion with iodized salt accessibility and thyroid function in an exclusive cohort of mothers residing in a mild iodine-deficient region rahim rostami0https://orcid.org/0000-0002-5504-6319Department of Clinical Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences Urmia, IranBackground & Aims: Maternal iodine deficiency (UIC<150 μg/L) is common in regions with borderline iodine sufficiency. Hence, exploring evolution of the temporal trend for UIC during pregnancy as well as impact of possible modifiers aids in defining the timing and the dose of iodide administration supplement during foetal development. The aim of present investigation was to evaluate the inter- relationships between UIC and iodized salt accessibility and thyroid function as assessed by thyroid-stimulating hormone (TSH) in an exclusive cohort of pregnant women depending on household salt as the predominant source of iodine intake. Materials and Methods: Healthy pregnant women (n=95; gestation > 4 and < 8 weeks) and non-pregnant women (n=40) with similar lifestyle and dietary habits were enrolled. UIC, TSH and table-salt iodine content were determined. Results: Median UIC (μg/L) according to trimesters was significantly lower than that of controls (61.6, 130.2 and 90.3 vs 133.8). Accordingly, prevalence of subjects with UIC<150 μg/L were 97.9, 67.4, 77.9 and 60. Median TSH (mIU/L) according to trimesters and control group were 1, 1.6, 1.4 and 1.6. Accordingly, prevalence of subjects with abnormal lower TSH limit was 17.2, 8.5, 3.2 and 2.4. Conclusion: This investigation demonstrates that UIC varies according to the foetal life cycle and that the highest frequencies of severe iodine (UIC <50 μg/L) were identified at the first- and third trimesters. This investigation paves the way for future studies aiming at exploring the therapeutic impact of iodine supplementation on body iodine stores during pregnancy.http://ijrabms.umsu.ac.ir/article-1-91-en.htmlthyroid stimulation hormone (tsh)urinary iodine excretion (uic)pregnancyiodinematernal iodine deficiency |
| spellingShingle | rahim rostami Inter-relationship between evolutions of the temporal trend of urinary iodine excretion with iodized salt accessibility and thyroid function in an exclusive cohort of mothers residing in a mild iodine-deficient region Journal of Research in Applied and Basic Medical Sciences thyroid stimulation hormone (tsh) urinary iodine excretion (uic) pregnancy iodine maternal iodine deficiency |
| title | Inter-relationship between evolutions of the temporal trend of urinary iodine excretion with iodized salt accessibility and thyroid function in an exclusive cohort of mothers residing in a mild iodine-deficient region |
| title_full | Inter-relationship between evolutions of the temporal trend of urinary iodine excretion with iodized salt accessibility and thyroid function in an exclusive cohort of mothers residing in a mild iodine-deficient region |
| title_fullStr | Inter-relationship between evolutions of the temporal trend of urinary iodine excretion with iodized salt accessibility and thyroid function in an exclusive cohort of mothers residing in a mild iodine-deficient region |
| title_full_unstemmed | Inter-relationship between evolutions of the temporal trend of urinary iodine excretion with iodized salt accessibility and thyroid function in an exclusive cohort of mothers residing in a mild iodine-deficient region |
| title_short | Inter-relationship between evolutions of the temporal trend of urinary iodine excretion with iodized salt accessibility and thyroid function in an exclusive cohort of mothers residing in a mild iodine-deficient region |
| title_sort | inter relationship between evolutions of the temporal trend of urinary iodine excretion with iodized salt accessibility and thyroid function in an exclusive cohort of mothers residing in a mild iodine deficient region |
| topic | thyroid stimulation hormone (tsh) urinary iodine excretion (uic) pregnancy iodine maternal iodine deficiency |
| url | http://ijrabms.umsu.ac.ir/article-1-91-en.html |
| work_keys_str_mv | AT rahimrostami interrelationshipbetweenevolutionsofthetemporaltrendofurinaryiodineexcretionwithiodizedsaltaccessibilityandthyroidfunctioninanexclusivecohortofmothersresidinginamildiodinedeficientregion |