Exosomes treating osteoarthritis: hope with challenge
Osteoarthritis (OA) has been proven as the second primary cause of pain and disability in the elderly population, impact patients both physically and mentally, as well as imposing a heavy burden on the global healthcare system. Current treatment methods, whether conservative or surgical, that aim at...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023003596 |
| _version_ | 1811173264135815168 |
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| author | Congxiao Wu Yunfan He Yao Yao Han Yang Feng Lu |
| author_facet | Congxiao Wu Yunfan He Yao Yao Han Yang Feng Lu |
| author_sort | Congxiao Wu |
| collection | DOAJ |
| description | Osteoarthritis (OA) has been proven as the second primary cause of pain and disability in the elderly population, impact patients both physically and mentally, as well as imposing a heavy burden on the global healthcare system. Current treatment methods, whether conservative or surgical, that aim at relieving symptoms can not delay or reverse the degenerative process in the structure. Scientists and clinicians are facing a revolution in OA treatment strategies. The emergence of exosomes brings hope for OA treatment based on pathology, which is attributed to its full potential in protecting chondrocytes from excessive death, alleviating inflammation, maintaining cartilage matrix metabolism, and regulating angiogenesis and subchondral bone remodeling. Therefore, we summarized the recent studies of exosomes in OA, aiming to comprehensively understand the functions and mechanisms of exosomes in OA treatment, which may provide direction and theoretical support for formulating therapeutic strategies in the future. |
| first_indexed | 2024-04-10T17:45:02Z |
| format | Article |
| id | doaj.art-165bfbc602a8412d978387dd4af57b97 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-10T17:45:02Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-165bfbc602a8412d978387dd4af57b972023-02-03T05:00:30ZengElsevierHeliyon2405-84402023-01-0191e13152Exosomes treating osteoarthritis: hope with challengeCongxiao Wu0Yunfan He1Yao Yao2Han Yang3Feng Lu4Department of Plastic Surgery, Shenzhen Qianhai Taikang Hospital, Shenzhen, 518000, Guangdong, ChinaDepartment of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, ChinaDepartment of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, ChinaDepartment of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, ChinaDepartment of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China; Corresponding author.Osteoarthritis (OA) has been proven as the second primary cause of pain and disability in the elderly population, impact patients both physically and mentally, as well as imposing a heavy burden on the global healthcare system. Current treatment methods, whether conservative or surgical, that aim at relieving symptoms can not delay or reverse the degenerative process in the structure. Scientists and clinicians are facing a revolution in OA treatment strategies. The emergence of exosomes brings hope for OA treatment based on pathology, which is attributed to its full potential in protecting chondrocytes from excessive death, alleviating inflammation, maintaining cartilage matrix metabolism, and regulating angiogenesis and subchondral bone remodeling. Therefore, we summarized the recent studies of exosomes in OA, aiming to comprehensively understand the functions and mechanisms of exosomes in OA treatment, which may provide direction and theoretical support for formulating therapeutic strategies in the future.http://www.sciencedirect.com/science/article/pii/S2405844023003596OsteoarthritisExosomesMesenchymal stem cellsChondrocytesExtracellular matrix |
| spellingShingle | Congxiao Wu Yunfan He Yao Yao Han Yang Feng Lu Exosomes treating osteoarthritis: hope with challenge Heliyon Osteoarthritis Exosomes Mesenchymal stem cells Chondrocytes Extracellular matrix |
| title | Exosomes treating osteoarthritis: hope with challenge |
| title_full | Exosomes treating osteoarthritis: hope with challenge |
| title_fullStr | Exosomes treating osteoarthritis: hope with challenge |
| title_full_unstemmed | Exosomes treating osteoarthritis: hope with challenge |
| title_short | Exosomes treating osteoarthritis: hope with challenge |
| title_sort | exosomes treating osteoarthritis hope with challenge |
| topic | Osteoarthritis Exosomes Mesenchymal stem cells Chondrocytes Extracellular matrix |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023003596 |
| work_keys_str_mv | AT congxiaowu exosomestreatingosteoarthritishopewithchallenge AT yunfanhe exosomestreatingosteoarthritishopewithchallenge AT yaoyao exosomestreatingosteoarthritishopewithchallenge AT hanyang exosomestreatingosteoarthritishopewithchallenge AT fenglu exosomestreatingosteoarthritishopewithchallenge |