SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk

SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk

The superoxide dismutase (SOD) is the principal antioxidant defense system in the body that is activated by a reactive oxygen species. Some variants of the <i>SOD2</i> gene have been associated with cancer. The rs4880 variant was determined by PCR real-time and the rs5746136 variant by P...

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Bibliographic Details
Main Authors: Martha P. Gallegos-Arreola, Ramiro Ramírez-Patiño, Josefina Y. Sánchez-López, Guillermo M. Zúñiga-González, Luis E. Figuera, Jorge I. Delgado-Saucedo, Belinda C. Gómez-Meda, Mónica A. Rosales-Reynoso, Ana M. Puebla-Pérez, María L. Lemus-Varela, Asbiel F. Garibaldi-Ríos, Nayely A. Marín-Domínguez, Diana P. Pacheco-Verduzco, Emaan A. Mohamed-Flores
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Current Issues in Molecular Biology
Subjects:
breast cancer
ROS
SOD2
variant
rs4880
rs5746136
Online Access:https://www.mdpi.com/1467-3045/44/11/355
Description
Summary:The superoxide dismutase (SOD) is the principal antioxidant defense system in the body that is activated by a reactive oxygen species. Some variants of the <i>SOD2</i> gene have been associated with cancer. The rs4880 variant was determined by PCR real-time and the rs5746136 variant by PCR-RFLP in healthy subjects and in breast cancer (BC) patients. The rs4880 and rs5746136 variants were associated with BC susceptibility when BC patients and the control group were compared for the <i>CT</i>, <i>TT</i>, <i>CTCC</i>, and the T alleles (<i>p</i> < 0.05). The <i>CT</i> genotype of the rs4880 variant showed significant statistical differences in patients and controls aged ≤ 45 years old, and with hormonal consumption (<i>p</i> < 0.05). The rs4880 variant was associated with BC patients with <i>CTTT</i> genotype and obesity, the presence of DM2-SAH, and a non-chemotherapy response (<i>p</i> < 0.05). Additionally, the rs5746136 variant was associated with susceptibility to BC with Ki-67 (≥20%), luminal A type BC, and a chemotherapy partial response (<i>p</i> < 0.05) in BC patients who carry <i>TT</i>, <i>TC</i>, and <i>CTTT</i> genotypes, respectively. The haplotype <i>T/T</i> (OR 1.98; 95% CI 1.20–3.26, <i>p</i> = 0.005) was observed to be a risk factor for BC. The rs4880 and rs5746136 variants in the SOD2 gene were associated with BC susceptibility.
ISSN:1467-3037
1467-3045

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