SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk
The superoxide dismutase (SOD) is the principal antioxidant defense system in the body that is activated by a reactive oxygen species. Some variants of the <i>SOD2</i> gene have been associated with cancer. The rs4880 variant was determined by PCR real-time and the rs5746136 variant by P...
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2022-10-01
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| author | Martha P. Gallegos-Arreola Ramiro Ramírez-Patiño Josefina Y. Sánchez-López Guillermo M. Zúñiga-González Luis E. Figuera Jorge I. Delgado-Saucedo Belinda C. Gómez-Meda Mónica A. Rosales-Reynoso Ana M. Puebla-Pérez María L. Lemus-Varela Asbiel F. Garibaldi-Ríos Nayely A. Marín-Domínguez Diana P. Pacheco-Verduzco Emaan A. Mohamed-Flores |
| author_facet | Martha P. Gallegos-Arreola Ramiro Ramírez-Patiño Josefina Y. Sánchez-López Guillermo M. Zúñiga-González Luis E. Figuera Jorge I. Delgado-Saucedo Belinda C. Gómez-Meda Mónica A. Rosales-Reynoso Ana M. Puebla-Pérez María L. Lemus-Varela Asbiel F. Garibaldi-Ríos Nayely A. Marín-Domínguez Diana P. Pacheco-Verduzco Emaan A. Mohamed-Flores |
| author_sort | Martha P. Gallegos-Arreola |
| collection | DOAJ |
| description | The superoxide dismutase (SOD) is the principal antioxidant defense system in the body that is activated by a reactive oxygen species. Some variants of the <i>SOD2</i> gene have been associated with cancer. The rs4880 variant was determined by PCR real-time and the rs5746136 variant by PCR-RFLP in healthy subjects and in breast cancer (BC) patients. The rs4880 and rs5746136 variants were associated with BC susceptibility when BC patients and the control group were compared for the <i>CT</i>, <i>TT</i>, <i>CTCC</i>, and the T alleles (<i>p</i> < 0.05). The <i>CT</i> genotype of the rs4880 variant showed significant statistical differences in patients and controls aged ≤ 45 years old, and with hormonal consumption (<i>p</i> < 0.05). The rs4880 variant was associated with BC patients with <i>CTTT</i> genotype and obesity, the presence of DM2-SAH, and a non-chemotherapy response (<i>p</i> < 0.05). Additionally, the rs5746136 variant was associated with susceptibility to BC with Ki-67 (≥20%), luminal A type BC, and a chemotherapy partial response (<i>p</i> < 0.05) in BC patients who carry <i>TT</i>, <i>TC</i>, and <i>CTTT</i> genotypes, respectively. The haplotype <i>T/T</i> (OR 1.98; 95% CI 1.20–3.26, <i>p</i> = 0.005) was observed to be a risk factor for BC. The rs4880 and rs5746136 variants in the SOD2 gene were associated with BC susceptibility. |
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| spelling | doaj.art-165c6bde51044b6591a3c9744e6d19562023-11-24T04:12:58ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-10-0144115221523310.3390/cimb44110355SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer RiskMartha P. Gallegos-Arreola0Ramiro Ramírez-Patiño1Josefina Y. Sánchez-López2Guillermo M. Zúñiga-González3Luis E. Figuera4Jorge I. Delgado-Saucedo5Belinda C. Gómez-Meda6Mónica A. Rosales-Reynoso7Ana M. Puebla-Pérez8María L. Lemus-Varela9Asbiel F. Garibaldi-Ríos10Nayely A. Marín-Domínguez11Diana P. Pacheco-Verduzco12Emaan A. Mohamed-Flores13División de Genética, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), 44340 Guadalajara, MexicoDepartamento de Medicina y Ciencias de la Vida, Centro Universitario la Ciénega, Universidad de Guadalajara, 47810 Ocotlán, MexicoDivisión de Genética, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), 44340 Guadalajara, MexicoDivisión de Medicina Molecular, CIBO, IMSS, 44340 Guadalajara, MexicoDivisión de Genética, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), 44340 Guadalajara, MexicoLaboratorio de Inmunofarmacología, Departamento de Farmacología, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, 44100 Guadalajara, MexicoDepartamento de Biología Molecular y Genómica, Instituto de Genética Humana “Dr. Enrique Corona Rivera”, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44100 Guadalajara, MexicoDivisión de Medicina Molecular, CIBO, IMSS, 44340 Guadalajara, MexicoLaboratorio de Inmunofarmacología, Departamento de Farmacología, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, 44100 Guadalajara, MexicoDepartamento de Neonatología, Hospital de Pediatría, UMAE, CMNO, IMSS, 44340 Guadalajara, MexicoDoctorado en Genética Humana, IGH, CUCS, Universidad de Guadalajara, 44100 Guadalajara, MexicoDivisión de Genética, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), 44340 Guadalajara, MexicoDivisión de Genética, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), 44340 Guadalajara, MexicoHospital de Gineco-Obstetricia, UMAE, CMNO, IMSS, 44340 Guadalajara, MexicoThe superoxide dismutase (SOD) is the principal antioxidant defense system in the body that is activated by a reactive oxygen species. Some variants of the <i>SOD2</i> gene have been associated with cancer. The rs4880 variant was determined by PCR real-time and the rs5746136 variant by PCR-RFLP in healthy subjects and in breast cancer (BC) patients. The rs4880 and rs5746136 variants were associated with BC susceptibility when BC patients and the control group were compared for the <i>CT</i>, <i>TT</i>, <i>CTCC</i>, and the T alleles (<i>p</i> < 0.05). The <i>CT</i> genotype of the rs4880 variant showed significant statistical differences in patients and controls aged ≤ 45 years old, and with hormonal consumption (<i>p</i> < 0.05). The rs4880 variant was associated with BC patients with <i>CTTT</i> genotype and obesity, the presence of DM2-SAH, and a non-chemotherapy response (<i>p</i> < 0.05). Additionally, the rs5746136 variant was associated with susceptibility to BC with Ki-67 (≥20%), luminal A type BC, and a chemotherapy partial response (<i>p</i> < 0.05) in BC patients who carry <i>TT</i>, <i>TC</i>, and <i>CTTT</i> genotypes, respectively. The haplotype <i>T/T</i> (OR 1.98; 95% CI 1.20–3.26, <i>p</i> = 0.005) was observed to be a risk factor for BC. The rs4880 and rs5746136 variants in the SOD2 gene were associated with BC susceptibility.https://www.mdpi.com/1467-3045/44/11/355breast cancerROSSOD2variantrs4880rs5746136 |
| spellingShingle | Martha P. Gallegos-Arreola Ramiro Ramírez-Patiño Josefina Y. Sánchez-López Guillermo M. Zúñiga-González Luis E. Figuera Jorge I. Delgado-Saucedo Belinda C. Gómez-Meda Mónica A. Rosales-Reynoso Ana M. Puebla-Pérez María L. Lemus-Varela Asbiel F. Garibaldi-Ríos Nayely A. Marín-Domínguez Diana P. Pacheco-Verduzco Emaan A. Mohamed-Flores SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk Current Issues in Molecular Biology breast cancer ROS SOD2 variant rs4880 rs5746136 |
| title | SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk |
| title_full | SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk |
| title_fullStr | SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk |
| title_full_unstemmed | SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk |
| title_short | SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk |
| title_sort | sod2 gene variants rs4880 and rs5746136 and their association with breast cancer risk |
| topic | breast cancer ROS SOD2 variant rs4880 rs5746136 |
| url | https://www.mdpi.com/1467-3045/44/11/355 |
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