Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination
Abstract Paroxysmal cold hemoglobinuria (PCH) is an extremely rare subtype of autoimmune hemolytic anemia (AIHA) in adults. PCH is caused by the biphasic Donath–Landsteiner (DL) antibody which fixes complement to red blood cells at low temperatures and dissociates at warmer temperatures, leading to...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
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Wiley
2022-08-01
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Series: | eJHaem |
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Online Access: | https://doi.org/10.1002/jha2.508 |
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author | Kyohei Misawa Hajime Yasuda Daisuke Koyama Tadaaki Inano Akemi Inoguchi Chinami Shirasu Hina Takano Noriaki Iwao Miki Ando Michiaki Koike |
author_facet | Kyohei Misawa Hajime Yasuda Daisuke Koyama Tadaaki Inano Akemi Inoguchi Chinami Shirasu Hina Takano Noriaki Iwao Miki Ando Michiaki Koike |
author_sort | Kyohei Misawa |
collection | DOAJ |
description | Abstract Paroxysmal cold hemoglobinuria (PCH) is an extremely rare subtype of autoimmune hemolytic anemia (AIHA) in adults. PCH is caused by the biphasic Donath–Landsteiner (DL) antibody which fixes complement to red blood cells at low temperatures and dissociates at warmer temperatures, leading to complement‐mediated intravascular hemolysis. Autoimmune hematological disorders including AIHA and immune thrombocytopenia have been reported to develop following the mRNA COVID‐19 vaccination. However, PCH developing subsequent to mRNA vaccination has never been reported. We report a 59‐year‐old male who developed PCH approximately a month after his second mRNA COVID‐19 vaccination. |
first_indexed | 2024-03-12T14:06:23Z |
format | Article |
id | doaj.art-165e557539f44db29146297933150b14 |
institution | Directory Open Access Journal |
issn | 2688-6146 |
language | English |
last_indexed | 2024-03-12T14:06:23Z |
publishDate | 2022-08-01 |
publisher | Wiley |
record_format | Article |
series | eJHaem |
spelling | doaj.art-165e557539f44db29146297933150b142023-08-21T14:06:34ZengWileyeJHaem2688-61462022-08-013399299510.1002/jha2.508Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccinationKyohei Misawa0Hajime Yasuda1Daisuke Koyama2Tadaaki Inano3Akemi Inoguchi4Chinami Shirasu5Hina Takano6Noriaki Iwao7Miki Ando8Michiaki Koike9Department of Hematology Juntendo University Shizuoka Hospital Izunokuni Shizuoka JapanDepartment of Hematology Juntendo University Graduate School of Medicine Bunkyo‐ku Tokyo JapanDepartment of Hematology Fukushima Medical University Fukushima Fukushima JapanDepartment of Hematology Juntendo University Shizuoka Hospital Izunokuni Shizuoka JapanDepartment of Clinical Laboratory Medicine Juntndo University Shizuoka Hospital Izunokuni Shizuoka JapanDepartment of Clinical Laboratory Medicine Juntndo University Shizuoka Hospital Izunokuni Shizuoka JapanDepartment of Hematology Juntendo University Shizuoka Hospital Izunokuni Shizuoka JapanDepartment of Hematology Juntendo University Shizuoka Hospital Izunokuni Shizuoka JapanDepartment of Hematology Juntendo University Graduate School of Medicine Bunkyo‐ku Tokyo JapanDepartment of Hematology Juntendo University Shizuoka Hospital Izunokuni Shizuoka JapanAbstract Paroxysmal cold hemoglobinuria (PCH) is an extremely rare subtype of autoimmune hemolytic anemia (AIHA) in adults. PCH is caused by the biphasic Donath–Landsteiner (DL) antibody which fixes complement to red blood cells at low temperatures and dissociates at warmer temperatures, leading to complement‐mediated intravascular hemolysis. Autoimmune hematological disorders including AIHA and immune thrombocytopenia have been reported to develop following the mRNA COVID‐19 vaccination. However, PCH developing subsequent to mRNA vaccination has never been reported. We report a 59‐year‐old male who developed PCH approximately a month after his second mRNA COVID‐19 vaccination.https://doi.org/10.1002/jha2.508autoimmune diseaseCOVID‐19 vaccinationparoxysmal cold hemoglobinuria |
spellingShingle | Kyohei Misawa Hajime Yasuda Daisuke Koyama Tadaaki Inano Akemi Inoguchi Chinami Shirasu Hina Takano Noriaki Iwao Miki Ando Michiaki Koike Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination eJHaem autoimmune disease COVID‐19 vaccination paroxysmal cold hemoglobinuria |
title | Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination |
title_full | Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination |
title_fullStr | Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination |
title_full_unstemmed | Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination |
title_short | Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination |
title_sort | adult paroxysmal cold hemoglobinuria following mrna covid 19 vaccination |
topic | autoimmune disease COVID‐19 vaccination paroxysmal cold hemoglobinuria |
url | https://doi.org/10.1002/jha2.508 |
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