Pharmacokinetic Study of Bioactive Flavonoids in the Traditional Japanese Medicine Keigairengyoto Exerting Antibacterial Effects against Staphylococcus aureus

Pharmacokinetic Study of Bioactive Flavonoids in the Traditional Japanese Medicine Keigairengyoto Exerting Antibacterial Effects against Staphylococcus aureus

Recent studies have demonstrated that flavonoid glucuronides can be deconjugated to the active form aglycone by β-glucuronidase-expressing macrophages. Keigairengyoto (KRT) is a flavonoid-rich traditional Japanese medicine reported to enhance bacterial clearance through immune modulation. Our aims a...

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Bibliographic Details
Main Authors: Takashi Matsumoto, Atsushi Kaneko, Junichi Koseki, Yosuke Matsubara, Setsuya Aiba, Kenshi Yamasaki
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:International Journal of Molecular Sciences
Subjects:
Keigairengyoto
bacterial infection
phagocytosis
macrophages
Staphylococcus aureus
flavonoid
pharmacokinetics
Online Access:http://www.mdpi.com/1422-0067/19/2/328

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